PD-L1/PD-1 pathway: a potential neuroimmune target for pain relief
Cell & Bioscience
by Daling Deng, Tianhao Zhang, Lulin Ma, Wenjing Zhao, Shiqian Huang, Kaixing Wang, Shaofang Shu and Xiangdong Chen
4d ago
Pain is a common symptom of many diseases with a high incidence rate. Clinically, drug treatment, as the main method to relieve pain at present, is often accompanied by different degrees of adverse reactions ..read more
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Ivermectin increases striatal cholinergic activity to facilitate dopamine terminal function
Cell & Bioscience
by Hillary A. Wadsworth, Alicia M. P. Warnecke, Joshua C. Barlow, J. Kayden Robinson, Emma Steimle, Joakim W. Ronström, Pacen E. Williams, Christopher J. Galbraith, Jared Baldridge, Michael W. Jakowec, Daryl L. Davies and Jordan T. Yorgason
4d ago
Ivermectin (IVM) is a commonly prescribed antiparasitic treatment with pharmacological effects on invertebrate glutamate ion channels resulting in paralysis and death of invertebrates. However, it can also act ..read more
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Microglia and macrophage metabolism: a regulator of cerebral gliomas
Cell & Bioscience
by Yue Deng, Qinyan Chen, Chao Wan, Yajie Sun, Fang Huang, Yan Hu and Kunyu Yang
1w ago
Reciprocal interactions between the tumor microenvironment (TME) and cancer cells play important roles in tumorigenesis and progression of glioma. Glioma-associated macrophages (GAMs), either of peripheral ori ..read more
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GLUT1-mediated microglial proinflammatory activation contributes to the development of stress-induced spatial learning and memory dysfunction in mice
Cell & Bioscience
by Xue Wang, Yuhan Wu, Yingrui Tian, Hui Hu, Yun Zhao, Binghua Xue, Zhaowei Sun, Aijun Wei, Fang Xie and Ling-Jia Qian
1w ago
Stress is a recognized risk factor for cognitive decline, which triggers neuroinflammation involving microglial activation. However, the specific mechanism for microglial activation under stress and affects le ..read more
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Cerebral venous congestion alters CNS homeostatic plasticity, evoking tinnitus-like behavior
Cell & Bioscience
by Huimin Wei, Huimin Jiang, Yifan Zhou, Lu Liu, Wei Ma, Shanshan Ni, Chen Zhou and Xunming Ji
2w ago
Brain function and neuronal activity depend on a constant supply of blood from the cerebral circulation. The cerebral venous system (CVS) contains approximately 70% of the total cerebral blood volume; similar ..read more
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Klotho exerts protection in chronic kidney disease associated with regulating inflammatory response and lipid metabolism
Cell & Bioscience
by Junhui Liu, Huaicheng Wang, Qinyu Liu, Shushu Long, Yanfang Wu, Nengying Wang, Wei Lin, Gang Chen, Miao Lin and Junping Wen
2w ago
The anti-aging protein Klotho plays a protective role in kidney disease, but its potential as a biomarker for chronic kidney disease (CKD) is controversial. Additionally, the main pathways through which Klotho ..read more
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Cellular and molecular mechanisms of aspartoacylase and its role in Canavan disease
Cell & Bioscience
by Martin Grønbæk-Thygesen and Rasmus Hartmann-Petersen
2w ago
Canavan disease is an autosomal recessive and lethal neurological disorder, characterized by the spongy degeneration of the white matter in the brain. The disease is caused by a deficiency of the cytosolic asp ..read more
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Crosstalk between m6A modification and autophagy in cancer
Cell & Bioscience
by Tao Chen, Liying Zheng, Peiyue Luo, Jun Zou, Wei Li, Qi Chen, Junrong Zou and Biao Qian
2w ago
Autophagy is a cellular self-degradation process that plays a crucial role in maintaining metabolic functions in cells and organisms. Dysfunctional autophagy has been linked to various diseases, including canc ..read more
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Complement C1q-mediated microglial synaptic elimination by enhancing desialylation underlies sevoflurane-induced developmental neurotoxicity
Cell & Bioscience
by Gang Wang, Hua-yue Liu, Xiao-wen Meng, Ying Chen, Wei-ming Zhao, Wen-ting Li, Han-bing Xu, Ke Peng and Fu-hai Ji
3w ago
Repeated neonatal sevoflurane exposures led to neurocognitive disorders in young mice. We aimed to assess the role of microglia and complement C1q in sevoflurane-induced neurotoxicity and explore the underlyin ..read more
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The role of goblet cells in Crohn’ s disease
Cell & Bioscience
by Zichen Wang and Jun Shen
3w ago
The prevalence of Crohn’s disease (CD), a subtype of inflammatory bowel disease (IBD), is increasing worldwide. The pathogenesis of CD is hypothesized to be related to environmental, genetic, immunological, an ..read more
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