Journal of Biochemistry and Molecular Biology Research
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JBMBR publishes original research, reviews, and other material related to Bioenergetics, Cell Biology, Chromosomes, Developmental biology, DNA, Enzymology, Extracellular Matrices, Gene Regulation, Genomics, Glycobiology, Immunology, Lipids, Membrane Biology, Membrane Biology, Metabolism, Molecular Bases of Disease, Molecular Biophysics, Neurobiology, Plant Biology, Protein Structure, and..
Journal of Biochemistry and Molecular Biology Research
3y ago
Important cellular signaling pathways control the basal metabolism in mammalian cells, mainly in combating oxidative stress. Several studies have correlated the increase in ROS as one of the causes of aging. However, some authors also point out that cell aging causes an increase in ROS, mainly due to the inhibition of important antioxidant pathways. Important pathways of protein kinases and transcription factors are important to combat the accumulation of ROS, promoting an increase in mitochondrial biogenesis, synthesis of antioxidant enzymes and decreasing cellular senescence. In this review ..read more