Sandor G. Vari Director, International Research, and Innovation in Medicine Program Cedars – Sinai Medical Center, Los Angeles, CA, USA ..read more

D. O. Labudzynskyi*, E. P. Pasichna, O. I. Krynina, М. M. Veliky Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv; *e-mail: labudzinskidmytro@gmail.com Received: 01 February 2024; Revised: 22 March 2024; Accepted: 24 March 2024; Available on-line: April 2024 Bisphosphonates (BPs) are primary agents in the current pharmacological arsenal against osteoclast-related bone loss due to osteoporosis, Paget disease, and bone tumours. Due to the lack of complete understanding of the molecular mechanism of their action in bone tissue and the overlap of key properties bet ..read more

M. V. Hrebenyk1, S. M. Maslii1, O. O. Shevchuk1*, M. M. Korda1, S. G. Vari2 1Ivan Horbachevsky Ternopil National Medical University of the Ministry of Health of Ukraine, Ternopil, Ukraine; 2International Research and Innovation in Medicine Program, Cedars–Sinai Medical Center, Los Angeles, CA, USA; *e-mail: shevchukoo@tdmu.edu.ua Received: 06 January 2024; Revised: 17 March 2024; Accepted: 17 March 2024; Available on-line: April 2024 COVID-19 has been associated with a wide range of cardiac sequelae after the acute phase. The goal of the study is to evaluate the spectrum of arrhythmias in the ..read more

O. S. Tkachenko*, H. V. Kosiakova Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv, Ukraine; *e-mail: 888oksana.tkachenko@gmail.com Received: 26 January 2024; Revised: 19 March 2024; Accepted: 19 March 2024; Available on-line: April 2024 Adiponectin is secreted by adipose tissue, associated with lipoprotein (LP) metabolism, down-regulated­ in insulin resistance states, and reduced in individuals suffering from obesity and cardiovascular diseases. Phospholipids and cholesterol are the main components of cell membranes and play a critical role in storage and secr ..read more

S. B. Kramar1*, I. Ya. Andriichuk2, N. V. Ohinska1, Yu. V. Soroka3, Z. M. Nebesna1, S. M. Dybkova4, L. S. Rieznichenko4, N. Ye. Lisnychuk2 1Department of Histology and Embryology, I. Horbachevsky Ternopil National Medical University, Ukraine; 2Central Research Laboratory, I. Horbachevsky Ternopil National Medical University, Ukraine; 3Department of Anaestesiology and Intensive Care, I. Horbachevsky Ternopil National Medical University, Ukraine; 4F.D. Ovcharenko Institute of Biocolloidal Chemistry, National Academy of Sciences of Ukraine, Kyiv; *e-mail: kramarsb@tdmu.edu.ua Received: 10 Februar ..read more

A. O. Tykhomyrov1*, O. Yu. Sirenko2, O. V. Kuryata2 1Department of Enzyme Chemistry and Biochemistry, Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv, Ukraine; 2Department of Internal Medicine 2, Phthisiology, Occupational Diseases and Clinical Immunology, Dnipro State Medical University, Dnipro, Ukraine; *e-mail: artem_tykhomyrov@ukr.net Received: 19 January 2024; Revised: 13 March 2024; Accepted: 17 March 2024; Available on-line: April 2024 Atrial fibrillation (AF) is the most common abnormal type of heart rhythm (cardiac arrhythmia), which is considered the ..read more

I. Shymanskyi1*, O. Lisakovska1, A. Khomenko1, L. Yanitska2, M. Veliky1 1Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv, Ukraine; 2Bogomolets National Medical University, Kyiv, Ukraine; *e-mail: ihorshym@gmail.com Received: 29 January 2024; Revised: 08 March 2024; Accepted: 11 March 2024; Available on-line: April 2024 Growing evidence suggests that vitamin D3 (D3, cholecalciferol) deficiency and impaired signaling of the hormonally active form of D3, 1α,25(OH)2D3 (1,25D3), through its cellular receptor (VDR) can be significant risk factors for the development ..read more

G. Bila1, O. Vishchur2, V. Vovk3, S. Vari4, R. Bilyy1* 1Department of Histology, Cytology and Embryology, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine; 2Institute of Animal Biology NAAS, Lviv, Ukraine; 3Department of Pathological Anatomy and Forensic Medicine, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine; 4International Research and Innovation in Medicine Program, Cedars-Sinai Medical Center, Los Angeles, California, USA; *e-mail: r.bilyy@gmail.com Received: 05 February 2024; Revised: 17 March 2024; Accepted: 17 March 2024; Available on-line: April 2024 No ..read more

A. Udovenko*, Ye. Makogonenko, O. Hornytska, G. Gogolinska, O. Yusova, V. Chernyshenko Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv; *e-mail: nudovenko26@gmail.com Received: 05 February 2024; Revised: 17 March 2024; Accepted: 17 March 2024; Available on-line: April 2024 Based on the turbidimetric curve of formation and dissolution of a blood plasma clot initiated by the activated partial thromboplastin time reagent, a method for determining the coagulation component of thrombin activity and fibrinolytic activity of plasmin is proposed. The activity of throm ..read more

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