The effect of aqueous extract of Irvingia wombolu seeds on lipid profile and atherogenic indices in hyperlipidemic wistar rats was evaluated. Forty five (45) wistar rats were grouped into five groups of nine rats each. The animals were allowed seven days acclimatization period. Group one was the control group and it received normal rat chow and water throughout the study. Groups 2 to 5 were given high fat diet for 14 days after which they were fed with normal rat chow till the end of the study. At the end of the 14 days, group 2 was not treated while group 3-5 were treated with 250, 500 and 10 ..read more

Young seedlings of five tea clones under cultivation (318, 236, 68, BB35, and 143) and five from the germplasm), were collected from the Kakara Highland tea Plantations, Mambila Plateau, Taraba State. Seedlings were planted in fifty sample boxes to enable the seedlings to be established first before transplanting to the field. After the establishment, they were transported to Obudu Hills for investigation. The experiment was laid out in a randomized complete block design (RBCD) with 3 replications. Data collected on morphological traits were subjected to an analysis of variance (ANOVA) test. M ..read more

Background: Chronic inflammation, a factor for high mortality, persists throughout the pregnancy period of women living with human immunodeficiency Virus (HIV). Aim: To determine whether pregnancy alone or the combined effects of HIV and pregnancy are the sources of the inflammation, this study evaluated the predictive variables for inflammation, lymphocyte ratio (NLR), and Platelet-Lymphocyte Ratio (PLR). Materials and Methods: A population of 128 women, aged 15-49 years were grouped into 4; Group A- 32 HIV positive and pregnant, Group B- 32 HIV negative and pregnant, Group C- 32 HIV positive ..read more

Mammea africana, a medicinal plant, used in ethnomedicine for the treatment of malaria, diabetes, poisoning and inflammatory diseases was investigated for cytotoxic and genotoxic effects on the root meristem cells of Allium cepa. Onion bulbs were exposed to 2.5 mg/mL, 5mg/mL, and 10 mg/mL concentrations of the stembark extract for macroscopic and microscopic analysis. Tap water was used as a negative control and Methotrexate (0.1 mg/mL) as a positive control. There was statistically significant (p< 0.05) inhibition of root growth depending on concentration by the extract when compared with ..read more

Benzo [a] pyrene is the main representative of polycyclic aromatic hydrocarbons, and has been repeatedly found in the air, surface water, soil, and sediments. Human exposure to Benzo [a] pyrene is therefore common. Benzo (a) pyrane (BaP) which is mainly presented in newspaper ink and inhibits the function of the thyroid and other endocrine glands of the human system, due to several disorders that occur in the human body. Healthy mature male mice Mus musculus having weight of 125 ± 5 gm were used for the experiments. The effects of a Benzo (a) pyrene (0.65mg/25g body weight/twice in a week) dur ..read more

Aims: This study investigated the antimicrobial resistance profile and extended spectrum beta-lactamase resistance genes in Escherichia coli of from urine of patients sourced from General Hospital, Karshi, Abuja, Nigeria. Study Design: Cross-sectional study. Place and Duration of Study: Department of Microbiology, Nasarawa State University, Keffi, between August 2022 and February 2023. Methodology: A total of 120 samples were collected from patients. Escherichia coli was isolated from the samples using standard microbiological methods. Antibiotic susceptibility testing was evaluated as describ ..read more

Cancer, a multifactorial disorder, arises due to defect in genetic makeup and exposure to unfavourable environmental conditions. Oral cancer, a life-threatening cancer worldwide, arises in the oral cavity due to ill-habits such as tobacco smoking and chewing. Monitoring body weight is an essential aspect of any preclinical study, including DMBA-induced oral carcinoma rat models and models with potential therapeutic interventions like Zingiber and piper feeding. Changes in body weight, feeding, water intake can provide valuable insights into the general health and physiological effects of the e ..read more

The present study reports experimental data on substrate specificity and some properties of the extracellular enzyme with oxidase activity isolated from the mycelium of the higher fungus Neonothopanus nambi IBSO 2391 by treating the biomass with \(\beta\) -glucosidase. Gel-filtration chromatography showed that molecular weight of the isolated enzyme was 80 kDa. Spectral analysis did not reveal any chromophore components in the enzyme. The extracellular oxidase of the basidiomycete N. nambi IBSO 2391 was active with most of the aromatic compounds chosen as model substrates. An important fact is ..read more

Plant viruses pose significant threats to agricultural productivity and food security worldwide. This article explores various management strategies employed to overcome the impact of plant viruses on crops, with a focus on enhancing crop health and productivity. It underscores the need for proactive management strategies to minimize yield losses, reduce disease spread, and maintain sustainable crop production through preventive measures such as Conventional and Non- conventional approaches by highlighting the key methods such as the use of resistant cultivars, cultural practices, vector contr ..read more

Heinsia crinata (Afzel.) G. Taylor (Rubiaceae), Justicia insularis T.  Anderson (Acanthaceae family) and Lasianthera africana. P.Beav (Stemonuraceae), which are used as vegetables in the preparation of soups and as medicine traditionally to treat various diseases by the Ibibios were investigated for genotoxic and cytotoxic effects using Allium cepa test. The effects of the leaf extracts on the root meristem cells of Allium cepa were investigated using onion bulbs exposed to 2.5 mg/mL, 5mg/mL, and 10 mg/mL concentrations of the extracts for macroscopic and microscopic analysis. Tap water w ..read more