Clinical & Experimental Allergy
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Clinical & Experimental Allergy is the Official Journal of the British Society for Allergy & Clinical Immunology, publishing clinical and experimental observations in disease in all fields of medicine in which allergic hypersensitivity plays a part. The journal strikes an excellent balance between clinical and scientific articles and carries regular reviews and editorials written by leading..
Role of epithelial barrier function in inducing type 2 immunity following early‐life viral infection
Clinical & Experimental Allergy
1w ago
Abstract Background
Preschool wheeze attacks triggered by recurrent viral infections, including respiratory syncytial virus (RSV), are associated with an increased risk of childhood asthma. However, mechanisms that lead to asthma following early-life viral wheezing remain uncertain.
Methods
To investigate a causal relationship between early-life RSV infections and onset of type 2 immunity, we developed a neonatal murine model of recurrent RSV infection, in vivo and in silico, and evaluated the dynamical changes of altered airway barrier function and downstream immune responses, including ..read more
Clinical & Experimental Allergy
2w ago
In a clinical population of children, latent class analysis identified four clinically relevant cough phenotypes and most children (70%) had a phenotype associated with allergies. The identified cough phenotypes differed with respect to parent-reported information about family histories and comorbidities, paediatric pulmonologist diagnoses, measurable traits, and respiratory prognosis one year later.
Abstract Introduction
Distinguishing phenotypes among children with cough helps understand underlying causes. Using a statistical data-driven approach, we aimed to identify and validate cough ph ..read more
Clinical & Experimental Allergy
2w ago
Lower numbers of mast cells are found in the vestibular area of the mouth than the sublingual area; vestibular administration of AIT-tablets could reduce AEs. Vestibular AIT-tablet administration was associated with a numerically higher frequency of severe AEs, treatment-related AEs and treatment discontinuations due to AEs than sublingual administration. Sublingual administration of AIT-tablets should remain the standard of care. AEs, adverse events; AIT, allergy immunotherapy; AR/C, allergic rhinitis/conjunctivitis; HDM, house dust mite; SAE, serious adverse event; TEAE, treatment-emergent ..read more
Clinical & Experimental Allergy
3w ago
Clinical &Experimental Allergy, Volume 53, Issue 11, Page 1138-1140, November 2023 ..read more
Clinical & Experimental Allergy
3w ago
Clinical &Experimental Allergy, Volume 53, Issue 11, Page 1141-1143, November 2023 ..read more
Clinical & Experimental Allergy
3w ago
Clinical &Experimental Allergy, Volume 53, Issue 11, Page 1135-1137, November 2023 ..read more