Clinical & Experimental Allergy
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Clinical & Experimental Allergy is the Official Journal of the British Society for Allergy & Clinical Immunology, publishing clinical and experimental observations in disease in all fields of medicine in which allergic hypersensitivity plays a part. The journal strikes an excellent balance between clinical and scientific articles and carries regular reviews and editorials written by leading..
Clinical & Experimental Allergy
2d ago
Allergen exposure chamber (AEC) challenge effectively evaluates timothy grass allergy in rhinitis patients. Symptom severity reproducibly correlates with timothy grass pollen concentrations. AEC challenge can be plausible for allergy diagnostics and patient stratification in clinical research. AEC, allergen exposure chamber; AR, allergic rhinitis; ARM, acoustic rhinometry; FEV1, forced expiratory volume in the first second; HC, healthy control; p/m3, particles/cubic meter; MCA, minimal cross-sectional area; PEFR, peak expiratory flow rate; PNIF, peak nasal inspiratory flow; TNSS, total nasal ..read more
Clinical & Experimental Allergy
2w ago
Abstract Background
Analysis of X (formerly Twitter) posts can inform on the interest/perceptions that social media users have on health subjects. In this study, we aimed to analyse tweets on allergic conditions, comparing them with surveillance data.
Methods
We retrieved tweets from England on “allergy,” “asthma,” and “allergic rhinitis,” published between 2016 and 2021. We estimated the correlation between the frequency of tweets on “asthma” and “allergic rhinitis” and English surveillance data on the incidence of asthma and allergic rhinitis medical visits. We performed sentiment analysis ..read more
Clinical & Experimental Allergy
2w ago
For early prediction of childhood asthma, an integrated risk score combining established risk-factors with genome-wide molecular markers (genotype, DNA methylation, mRNA expression) at birth was defined, complemented by subsequent clinical symptoms/diagnoses (wheeze, atopic dermatitis, food allergy). While epidemiological predictors have moderate predictive power, molecular markers from birth improve prediction to a modest extent. Including allergic symptoms/diagnoses significantly increased predictive efficiency.
Abstract Background
Numerous children present with early wheeze symptoms, yet ..read more
Clinical & Experimental Allergy
2w ago
The efficacy of a 300 IR HDM SLIT tablet in three RCTs was evaluated in a tertile analysis. The treatment efficacy increased with the placebo score level in each tertile, regardless of the RCT and the combined score used. In the tertile with the highest disease activity, the 300 IR HDM SLIT tablet was associated with greater treatment efficacy.
Abstract Background
The symptoms of house dust mite (HDM)-induced allergic rhinitis (AR) vary with changes in exposure related to the weather or the domestic environment. In allergen immunotherapy (AIT) studies, a certain level of AR disease activity ..read more