Allergies, Vol. 3, Pages 220-228: Allergic Rhinitis Systematic Review Shows the Trends in Prevalence in Children and Adolescents in Greece since 1990 Allergies doi: 10.3390/allergies3040014 Authors: Christos Kogias Aikaterini Drylli Demosthenes Panagiotakos Konstantinos Douros George Antonogeorgos Allergic rhinitis is the most common immune disorder worldwide, affecting approximately 10–40% of the general population. It is characterized by an inflammatory response of the nasal mucosa following exposure to non-infectious, inhaled, and airborne allergens that are defined based on t ..read more

Allergies, Vol. 3, Pages 202-219: Effect of Eriobotrya japonica Leaf Supplements on Allergic Rhinitis Symptoms and Skin Conditions in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Study Allergies doi: 10.3390/allergies3040013 Authors: Masumi Nagae Maki Nagata Masako Matsumoto Naomichi Takemoto Yhiya Amen Dongmei Wang Yuri Yoshimitsu Kuniyoshi Shimizu Eriobotrya japonica (E. japonica) leaves have been used as an herbal traditional medicine in China and Japan owing to their anti-inflammatory and protective effects against skin conditions and allergy symptoms. These beneficial ef ..read more

Allergies, Vol. 3, Pages 184-201: Removal of N-Terminal Peptide Impacts Structural Aspects of an IgE-Reactive Recombinant Der p 5 Allergies doi: 10.3390/allergies3030012 Authors: Camilo J. B. Vieira Raphael C. Silva Elisânia F. Silveira Antônio M. S. Fernandes Dumar A. Jaramillo-Hernández Luis F. S. Garcés Larissa M. S. Fonseca Bruna A. S. Machado Jamille S. Fernandes Gabriela P. Pinheiro Álvaro A. Cruz Fatima Ferreira Philip Cooper Luis G. C. Pacheco Neuza M. Alcantara-Neves Carina S. Pinheiro Eduardo S. da Silva (1) Background: Modification of the structural elements of allergens is widely u ..read more

Allergies, Vol. 3, Pages 177-183: The Role of Peamaclein (Pru p 7) in PFAS Patients: An Italian Real-Life Study Allergies doi: 10.3390/allergies3030011 Authors: Marco Spalletti Valentina Lasala Paolo Cameli Laura Bergantini Marco Saletti Valerio Beltrami Elena Bargagli Miriana d’Alessandro Pollen food allergy syndrome (PFAS) is an allergic reaction to specific foods in persons previously sensitised to pollen. The diagnosis of PFAS is made after taking a patient’s medical history and, in some cases, conducting skin tests and oral food tests with raw fruit or vegetables. The aim of ..read more

Allergies, Vol. 3, Pages 134-176: An Overview of Fruit Allergens: Structural, Functional, Phylogenetical, and Clinical Aspects Allergies doi: 10.3390/allergies3030010 Authors: Annick Barre Hervé Benoist Pierre Rougé Most of the allergenic proteins from fruits identified so far belong to different families of pathogenesis-related (PR) proteins. These PR proteins have been classified in different families of structurally and functionally unrelated proteins, but the majority of all fruit allergens belong to three groups, in particular PR-5 thaumatin-like proteins (TLP), PR-10 Bet v 1-like protein ..read more

Allergies, Vol. 3, Pages 115-133: Genetic and Epigenetic Factors in Risk and Susceptibility for Childhood Asthma Allergies doi: 10.3390/allergies3020009 Authors: Dimitrina Miteva Snezhina Lazova Tsvetelina Velikova Asthma is a common respiratory disease that affects people of all ages, characterized by considerable heterogeneity in age, clinical presentation, genetics, epigenetics, environmental factors, treatment response, and prognostic outcomes. Asthma affects more than 330 million people worldwide, of which 33% are children under 14 years, and 27% are adults whose first symptoms occurred i ..read more

Allergies, Vol. 3, Pages 90-104: Targeting IgE and Th2-Cytokines in Allergy: Brief Updates on Monoclonal Antibodies and Antibody Gene Therapy Allergies doi: 10.3390/allergies3020007 Authors: Henry C. Ezechukwu Oyelola A. Adegboye Wahab O. Okunowo Theophilus I. Emeto The search for an effective treatment of allergic conditions is an ongoing global health challenge due to the high prevalence of allergies. Epinephrine and glucocorticosteroids remain the oldest and most widely used treatment regimen for allergy, and these medications are for short relief. In extreme allergy manifestations, the cur ..read more

Allergies, Vol. 3, Pages 72-89: Efficacy and Safety of Oral Probiotics in Children with Allergic Rhinitis: A Review Allergies doi: 10.3390/allergies3010006 Authors: Angela Klain Giulio Dinardo Cristiana Indolfi Marcella Contieri Alessandra Salvatori Sossio Vitale Fabio Decimo Giorgio Ciprandi Michele Miraglia del Giudice The prevalence of allergic rhinitis is rising, and it is impacting children’s growth and quality of life. To uncover unconventional treatment modalities, research was carried out to clarify the significance of novel components in the pathophysiology of allergic r ..read more

Allergies, Vol. 3, Pages 58-71: Multiplex Specific IgE Profiling in Neonatal Stool of Preterms Predicts IgE-Mediated Disease Allergies doi: 10.3390/allergies3010005 Authors: Youssouf Sereme Moïse Michel Soraya Mezouar Nicolas Orain Renaud Cezar Tran Tu Tu Anh Pierre Corbeau Anne Filleron Joana Vitte Background: The natural history of immunoglobulin (Ig) E-mediated diseases in preterm infants is still elusive. We aimed at developing a non-invasive tool for detecting specific IgE (sIgE) and eosinophil-derived neurotoxin (EDN) in neonatal fecal samples and evaluating its predictive value for the ..read more

Allergies, Vol. 3, Pages 25-38: Seed Storage Protein, Functional Diversity and Association with Allergy Allergies doi: 10.3390/allergies3010003 Authors: Abha Jain Plants are essential for humans as they serve as a source of food, fuel, medicine, oils, and more. The major elements that are utilized for our needs exist in storage organs, such as seeds. These seeds are rich in proteins, show a broad spectrum of physiological roles, and are classified based on their sequence, structure, and conserved motifs. With the improvements to our knowledge of the basic sequence and our structural understand ..read more