Allergies, Vol. 4, Pages 42-53: The Indirect Costs of Avoidance in Food Allergy Management: A Scoping Review Allergies doi: 10.3390/allergies4020004 Authors: Jennifer L. P. Protudjer Melissa L. Engel Background: Food allergy management requires avoidance of allergenic food. While the direct costs of food allergy management have been described, avoidance may also contribute to time and opportunity costs. We aimed to conduct a scoping review of the peer-reviewed literature on the indirect costs of food allergy, and to characterise these costs through a series of fictitious case studies. Methods ..read more

Allergies, Vol. 4, Pages 30-41: Impact of Pharmacist-Driven Penicillin Allergy De-Labeling Pilot Program in Preoperative Cardiothoracic and Spine Surgery Patients at Quaternary Hospital Allergies doi: 10.3390/allergies4020003 Authors: Hannah Crum Brandon Gagnon Alexis Thumann Abbey Sidebottom Marc Vacquier Krista Gens Documented penicillin allergies are associated with an increased risk of surgical site infections (SSIs), and first-line antibiotics (e.g., cefazolin) are associated with a lower risk of SSIs. The goal of this study was to evaluate the effect of a pharmacist-driven penicillin all ..read more

Allergies, Vol. 4, Pages 17-29: Mechanisms and Comparative Treatments of Allergic Rhinitis including Phototherapy Allergies doi: 10.3390/allergies4010002 Authors: Roy Kennedy The treatment of allergic conditions presents a challenge for both seasonal allergic rhinitis and perennial rhinitis sufferers. The increasing prevalence of both of these types of allergic responses requires the use of a range of treatments which can provide relief. The treatment of allergic rhinitis has been considered under the ARIA (Allergic Rhinitis and its Impact on Asthma) guidelines. Current treatment options inclu ..read more

Allergies, Vol. 3, Pages 220-228: Allergic Rhinitis Systematic Review Shows the Trends in Prevalence in Children and Adolescents in Greece since 1990 Allergies doi: 10.3390/allergies3040014 Authors: Christos Kogias Aikaterini Drylli Demosthenes Panagiotakos Konstantinos Douros George Antonogeorgos Allergic rhinitis is the most common immune disorder worldwide, affecting approximately 10–40% of the general population. It is characterized by an inflammatory response of the nasal mucosa following exposure to non-infectious, inhaled, and airborne allergens that are defined based on t ..read more

Allergies, Vol. 3, Pages 202-219: Effect of Eriobotrya japonica Leaf Supplements on Allergic Rhinitis Symptoms and Skin Conditions in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Study Allergies doi: 10.3390/allergies3040013 Authors: Masumi Nagae Maki Nagata Masako Matsumoto Naomichi Takemoto Yhiya Amen Dongmei Wang Yuri Yoshimitsu Kuniyoshi Shimizu Eriobotrya japonica (E. japonica) leaves have been used as an herbal traditional medicine in China and Japan owing to their anti-inflammatory and protective effects against skin conditions and allergy symptoms. These beneficial ef ..read more

Allergies, Vol. 3, Pages 184-201: Removal of N-Terminal Peptide Impacts Structural Aspects of an IgE-Reactive Recombinant Der p 5 Allergies doi: 10.3390/allergies3030012 Authors: Camilo J. B. Vieira Raphael C. Silva Elisânia F. Silveira Antônio M. S. Fernandes Dumar A. Jaramillo-Hernández Luis F. S. Garcés Larissa M. S. Fonseca Bruna A. S. Machado Jamille S. Fernandes Gabriela P. Pinheiro Álvaro A. Cruz Fatima Ferreira Philip Cooper Luis G. C. Pacheco Neuza M. Alcantara-Neves Carina S. Pinheiro Eduardo S. da Silva (1) Background: Modification of the structural elements of allergens is widely u ..read more

Allergies, Vol. 3, Pages 177-183: The Role of Peamaclein (Pru p 7) in PFAS Patients: An Italian Real-Life Study Allergies doi: 10.3390/allergies3030011 Authors: Marco Spalletti Valentina Lasala Paolo Cameli Laura Bergantini Marco Saletti Valerio Beltrami Elena Bargagli Miriana d’Alessandro Pollen food allergy syndrome (PFAS) is an allergic reaction to specific foods in persons previously sensitised to pollen. The diagnosis of PFAS is made after taking a patient’s medical history and, in some cases, conducting skin tests and oral food tests with raw fruit or vegetables. The aim of ..read more

Allergies, Vol. 3, Pages 134-176: An Overview of Fruit Allergens: Structural, Functional, Phylogenetical, and Clinical Aspects Allergies doi: 10.3390/allergies3030010 Authors: Annick Barre Hervé Benoist Pierre Rougé Most of the allergenic proteins from fruits identified so far belong to different families of pathogenesis-related (PR) proteins. These PR proteins have been classified in different families of structurally and functionally unrelated proteins, but the majority of all fruit allergens belong to three groups, in particular PR-5 thaumatin-like proteins (TLP), PR-10 Bet v 1-like protein ..read more

Allergies, Vol. 3, Pages 115-133: Genetic and Epigenetic Factors in Risk and Susceptibility for Childhood Asthma Allergies doi: 10.3390/allergies3020009 Authors: Dimitrina Miteva Snezhina Lazova Tsvetelina Velikova Asthma is a common respiratory disease that affects people of all ages, characterized by considerable heterogeneity in age, clinical presentation, genetics, epigenetics, environmental factors, treatment response, and prognostic outcomes. Asthma affects more than 330 million people worldwide, of which 33% are children under 14 years, and 27% are adults whose first symptoms occurred i ..read more

Allergies, Vol. 3, Pages 90-104: Targeting IgE and Th2-Cytokines in Allergy: Brief Updates on Monoclonal Antibodies and Antibody Gene Therapy Allergies doi: 10.3390/allergies3020007 Authors: Henry C. Ezechukwu Oyelola A. Adegboye Wahab O. Okunowo Theophilus I. Emeto The search for an effective treatment of allergic conditions is an ongoing global health challenge due to the high prevalence of allergies. Epinephrine and glucocorticosteroids remain the oldest and most widely used treatment regimen for allergy, and these medications are for short relief. In extreme allergy manifestations, the cur ..read more