American Journal of Rhinology &Allergy, Ahead of Print. BackgroundThe nose can be damaged by environmental pollutants and foreign bodies, as well as a result of trauma, infection or surgical interventions. Proper healing of the damaged nasal mucosa is important for health.ObjectiveThere is no study in the literature investigating the effects of rosmarinic acid on mucosal healing. The aim of this study was to investigate the effect of rosmarinic acid on nasal mucosal healing.Methods21 male, adult Spraque Dawley albino rats were divided into three groups as the control group, the local treat ..read more

American Journal of Rhinology &Allergy, Ahead of Print. BackgroundFrontal sinus surgery remained a challenge of restenosis or obliteration of the drainage pathway caused by the scarring and neo-osteogenesis after mucosal stripping and bone drill-out. The pedicled or free nasal mucosal flap is typically used to repair the exposed bone surface to avoid or reduce recurrence.ObjectiveThis study aimed to explore the histopathological mechanism of mucosal flaps repairing bare bone after mucosal resection and bone drill-out in the rabbit model.MethodsThirty New Zealand white rabbits were used. Si ..read more

American Journal of Rhinology &Allergy, Ahead of Print. BackgroundOver the last few decades, reflux diseases, such as laryngopharyngeal reflux (LPR) and gastroesophageal reflux disease (GERD), have been identified as significant contributors to inflammatory upper aerodigestive tract diseases. Establishing a direct relationship between reflux disease and chronic rhinosinusitis (CRS) is challenging due to the high prevalence of both diseases and their potential for independent coexistence.ObjectiveThe purpose of this study is to review the existing literature and evaluate the evidence of an ..read more

American Journal of Rhinology &Allergy, Ahead of Print. BackgroundStudies evaluating health-related quality of life (HRQOL) in patients with hereditary hemorrhagic telangiectasia (HHT) have expanded rapidly in the past decade. These studies have evaluated QOL aspects ranging from the general QOL for patients living with HHT to intervention-specific outcomes. However, few tools have been fully validated across the spectrum of disease manifestations and interventions in HHT.ObjectiveIn this scoping review, we aim to map the literature on HHT-QOL metrics, identify gaps, inform future QOL rese ..read more

American Journal of Rhinology &Allergy, Ahead of Print. BackgroundThe Epistaxis Severity Score (ESS) is the gold-standard patient-reported outcome measure for evaluating nosebleed severity in patients with hereditary hemorrhagic telangiectasia (HHT). To date, the ESS has been assessed only for content validity and concurrent validity.ObjectiveWe evaluate the internal consistency and test–retest reliability of the ESS.Materials and MethodsAfter receiving institutional review board approval, we sent an online survey battery, including the ESS survey, to 305 (39% male) English-speaking HHT pa ..read more

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American Journal of Rhinology &Allergy, Ahead of Print. ObjectiveThe purpose of this study is to characterize the presentation, outcomes, and barriers to care for White and non-White patients undergoing endoscopic sinus surgery (ESS).BackgroundESS is often successful in providing long-term relief for patients suffering from chronic rhinosinusitis (CRS). Literature that uses robust measures of socioeconomic status (SES) and barriers to care to assess ESS outcomes is limited.MethodsA retrospective matched cohort study of patients who underwent ESS for CRS between 1/1/2015 and 6/1/2021 at a s ..read more

American Journal of Rhinology &Allergy, Ahead of Print. BackgroundEosinophilic chronic rhinosinusitis (eCRS) is a type 2 inflammatory disease that frequently recurs after surgery. In recent years, dupilumab has been available for the treatment of refractory chronic rhinosinusitis since 2020 in Japan. Although there are some reports of its usefulness, there are not enough reports of its clinical efficacy for longer than 1 year, especially for olfactory recovery.MethodsTwenty patients with eCRS who had recurrence after surgery and had been receiving dupilumab were enrolled retrospectively. T ..read more

American Journal of Rhinology &Allergy, Ahead of Print. BackgroundEustachian tube balloon dilation (ETBD) has been Food and Drug Administration (FDA) approved for refractory Eustachian tube dysfunction since 2016. While ETBD is generally seen as safe, the complication profile has not been well defined.ObjectiveThe objective of this study was to utilize the FDA manufacturer and user facility device experience (MAUDE) database to better assess adverse events (AE) related to ETBD.MethodsThis is a study of a multiinstitutional database maintained by the U.S. FDA. A database analysis was perfor ..read more

American Journal of Rhinology &Allergy, Ahead of Print. BackgroundEpigenetics studies mechanisms such as DNA methylation, histone modifications, non-coding RNAs, and alternative polyadenylation that can modify gene activity without changing the underlying DNA nucleotide base-pair structure. Because these changes are reversible, they have potential in developing novel therapeutics. Currently, seven pharmaceutical agents targeting epigenetic changes are FDA approved and commercially available for treatment of certain cancers. However, studies investigating epigenetics in chronic rhinosinusit ..read more