In this episode, Jake leads us in a discussion of a manuscript entitled Once-Weekly Semaglutide in Adults with Overweight or Obesity (10.1056/NEJMoa2032183). This manuscript is the result of a massive international randomized clinical trial that enrolled 1961 people with overweight and obesity to examine the effect of once-weekly semaglutide on weight loss. These data have the potential to make a big change to how obesity and overweight are treated. Look out for our follow up episode where we look at a similar GLP1 receptor agonist (liraglutide) and the efficacy of adding exercise to the pharm ..read more

On this episode of the podcast our special guest Dr. Chris Wolff, talk about the interactions between exercise, circadian rhythm and exercise by highlighting a paper published in Cell metabolism in 2019 entitled, “Time of Exercise Specifies the Impact on Muscle Metabolic Pathways and Systemic Energy Homeostasis”.  Dr. Wolff will also discuss some of the workin he is doing as a post doc in Dr. Karyn Esser's lab at the University of Florida in this area.   Time Stamps Introduction                  &nbs ..read more

In this episode, Alec continues our Exercise for Health series, by highlighting a recent article published out of the journal of clinical endocrinology and metabolism, entitled “Lipid Metabolism Links Nutrient-Exercise Timing to Insulin Sensitivity in Men Classified as Overweight or Obese,” which investigates the interplay between timing morning exercise and breakfast to optimize exercise-induced increases in insulin sensitivity in males with obesity.    DOI for the Main Article 10.1210/clinem/dgz104 Episode Time Stamps INTRODUCTION&n ..read more

This episode kicks off our series on Exercise for Health. In this series we will highlight several benefits that exercise has on general health as well as the current literature examining the potential mechanisms providing these benefits, if there is an optimal mode/intensity/timing of exercise, and much more! This episode starts by framing everyone’s expectations of exercise, especially when it comes to eliciting weight loss.  What should the expected weight loss from an exercise regimen be? Is more exercise better? This discussion c ..read more

In this episode, Jake leads our discussion to close out our series on the topic of bariatric surgery. Our focus will be on the STAMPEDE trial, which was a randomized clinical trial investigating the impact of bariatric surgery versus medical therapy (lifestyle) in patients with diabetes. Here we discuss 3 papers from the trial, all published in NEJM and discuss their clinical outcome results and metabolic implications at 1, 3 and 5-year time points.    DOI for main articles: 1-year - 10.1056/NEJMoa1200225 3-year - 10.1056/NEJMoa1401329 5-year - 10.1056/NEJMoa1600869 7-year (LABS) - 1 ..read more

In this episode Dr. Austin Robinson and I are joined by Dr. Rich Severin to discuss the paper we covered on the last episode of the podcast which examined the effects of obesity and bariatric surgery on cardiovascular health and carotid intima-media thickness at a 3-year follow-up. We also discussed some of the exciting work Rich currently is doing as a part of his dissertation on the effects of obesity and endothelial function as well as his recent review paper entitled, “Endothelial Function in Obesity and Effects of Bariatric and Metabolic Surgery” (DOI below). Rich is a Doctor of Physical ..read more

In this episode Dr. Austin Robinson is leading our discussion of a paper entitled, “Bariatric Surgery-Induced Changes in Intima-Media Thickness and Cardiovascular Risk Factors in Class 3 Obesity: A 3-Year Follow-Up Study”. This paper was published in the journal of Obesity this August and continues our discussion of the many beneficial effects of bariatric surgery. Along with this episode we will also be posting a discussion with one of our colleagues at UIC Dr. Rich Severn. Rich is a DPT and PhD candidate at UIC whom we all worked with when we were at UIC. Be sure to catch our discussion with ..read more

In this companion episode we had the pleasure of talking with metabolism expert Dr. Lynis Dohm about his manuscript that we discussed in the last episode and his Vicious Cori Cycle hypothesis. In this episode we talk a lot about the ability of lactate to provide insight into metabolic health. Lactate, the seemingly inauspicious metabolite wrought with misleading narratives including those that implicate it as a cause of muscle fatigue with exercise, has never been so exciting!   ..read more

In this episode Alec leads our discussion on work published out of East Carolina University’s Metabolic Surgery Research Group, the translational research institute in Florida, and Duke University Medical Center, investigating the effects of obesity and bariatric surgery on plasma lactate and skeletal muscle glucose handling entitled “Plasma lactate as a marker of metabolic health: Implications of elevated lactate for impairment of aerobic metabolism in the metabolic syndrome” published in Surgery last year in June.  Follow along ..read more

This episode follows up on our discussion of Sam Klein's NEJM manuscript (Episode 9: Released on October 13th) which attempts to compare the effects of diet and bariatric surgery-mediated weight loss on glucose control and diabetes.  Dr. Phil Schauer is a world-renown bariatric surgeon and also a scholastic leader in research surrounding the pathophysiology of obesity and diabetes and outcomes of metabolic surgery. Notably, Dr. Schauer performed the first laproscopic bariatric surgery in 1997 and his work onthe STAMPEDE trial was one of the first trials to demonstrate the ability of baria ..read more