Nature Aging, Published online: 19 July 2024; doi:10.1038/s43587-024-00679-z Rejections by peer-reviewed journals are frequent, but authors may get a second chance to convince editors and peers by submitting an appeal. Here we explain how we approach appeals at Nature Aging and share some statistics on them to help authors to carefully consider when and how to appeal ..read more

Nature Aging, Published online: 17 July 2024; doi:10.1038/s43587-024-00669-1 Zeng, Shi, Han, Hu, Li, Wei et al. present a metabolic atlas covering 15 hematopoietic cell types from young and aged mice. By screening metabolites that are depleted with age, they identify that uridine treatment can restore function in aged hematopoietic stem cells ..read more

Nature Aging, Published online: 15 July 2024; doi:10.1038/s43587-024-00675-3 A Comment that discusses how biomarkers might be used in clinical practice to improve the diagnostic work-up of Alzheimer’s disease. It also highlights key knowledge gaps that need addressing before global clinical implementation of such markers ..read more

Nature Aging, Published online: 12 July 2024; doi:10.1038/s43587-024-00668-2 SARS-CoV-2 infections are typically more severe with increased age. Vaccination can reduce morbidity and mortality, but the age-associated decline in immune function could limit vaccine efficacy in older adults. Dallan, Proietto and colleagues demonstrate robust immunological humoral and cellular memory in older adults who received primary vaccinations using the adenoviral platforms and received subsequent boosting with mRNA vaccine platforms ..read more

Nature Aging, Published online: 10 July 2024; doi:10.1038/s43587-024-00655-7 Gadd et al. identify proteins circulating in the blood that can stratify the risk people have of developing a range of leading age-related diseases, up to a decade before onset ..read more

Nature Aging, Published online: 10 July 2024; doi:10.1038/s43587-024-00680-6 Identification of patients at risk for hip fracture is crucial to inform intervention strategies. We developed a plasma protein-based risk score for hip fracture and validated this score in three independent cohorts using two substantially different proteomics platforms. The protein-based risk score, but not available polygenic risk scores, improved hip fracture discrimination ..read more

Nature Aging, Published online: 09 July 2024; doi:10.1038/s43587-024-00677-1 A distinct aging-enriched platelet differentiation pathway ..read more

Nature Aging, Published online: 08 July 2024; doi:10.1038/s43587-024-00673-5 Pharmacological TERT activation attenuates phenotypes of natural aging ..read more

Nature Aging, Published online: 08 July 2024; doi:10.1038/s43587-024-00664-6 A study demonstrates the efficacy of immune-checkpoint blockade in prolonging survival and boosting CD8+ T cell function in aged mice after pathogen exposure. These findings highlight how aging-related immune changes may lead to augmented CD8+ T cell responses to checkpoint blockade, which results in improved protection from infection. The findings also highlight the importance of understanding immune aging in future efforts to target immunotherapies to older adults ..read more

Nature Aging, Published online: 02 July 2024; doi:10.1038/s43587-024-00665-5 A deep learning model accurately predicts 1-year mortality for the entire Finnish population. Despite robust performance and potential as a digital marker of aging, fairness analyses reveal prediction disparities, so integration into public health should be approached cautiously ..read more