Latin American brain-health research requires regional data and tailored models
Nature Aging
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11h ago
Nature Aging, Published online: 18 June 2024; doi:10.1038/s43587-024-00656-6 We reveal considerable heterogeneity in risk factors for healthy aging in Latin America, which underscores the limitations of existing, unharmonized research models for diverse populations. Our results emphasize the urgent need for region-specific studies that describe particular risks for Latin American aging to develop tailored preventive models and interventions ..read more
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Healthy aging meta-analyses and scoping review of risk factors across Latin America reveal large heterogeneity and weak predictive models
Nature Aging
by Agustin Ibanez, Marcelo Maito, Felipe Botero-Rodríguez, Sol Fittipaldi, Carlos Coronel, Joaquin Migeot, Andrea Lacroix, Brian Lawlor, Claudia Duran-Aniotz, Sandra Baez, Hernando Santamaria-Garcia
11h ago
Nature Aging, Published online: 17 June 2024; doi:10.1038/s43587-024-00648-6 Ibanez et al. performed a scoping review and meta-analysis of healthy aging studies across Latin America and report substantial heterogeneity in how risk factors affect cognitive and functional ability, underscoring the need for further regional research ..read more
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Slowing early Parkinson’s disease
Nature Aging
by George Andrew S. Inglis
11h ago
Nature Aging, Published online: 17 June 2024; doi:10.1038/s43587-024-00660-w Slowing early Parkinson’s disease ..read more
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Social connection affects end-of-life well-being
Nature Aging
by Anna Kriebs
11h ago
Nature Aging, Published online: 17 June 2024; doi:10.1038/s43587-024-00658-4 Social connection affects end-of-life well-being ..read more
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Functional declines raise risk of heatwave mortality
Nature Aging
by Hannah Walters
11h ago
Nature Aging, Published online: 14 June 2024; doi:10.1038/s43587-024-00659-3 Functional declines raise risk of heatwave mortality ..read more
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Addressing gender disparities in global health
Nature Aging
by Yahyah Aman
11h ago
Nature Aging, Published online: 14 June 2024; doi:10.1038/s43587-024-00661-9 Addressing gender disparities in global health ..read more
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Conserved epigenetic hallmarks of T cell aging during immunity and malignancy
Nature Aging
by Tian Mi, Andrew G. Soerens, Shanta Alli, Tae Gun Kang, Anoop Babu Vasandan, Zhaoming Wang, Vaiva Vezys, Shunsuke Kimura, Ilaria Iacobucci, Stephen B. Baylin, Peter A. Jones, Christopher Hiner, April Mueller, Harris Goldstein, Charles G. Mullighan, Caitlin C. Zebley, David Masopust, Ben Youngblood
1w ago
Nature Aging, Published online: 12 June 2024; doi:10.1038/s43587-024-00649-5 Using an iterative boost and transplantation model to generate multilifetime T cells, Mi et al. show that cellular epigenetic age can be uncoupled from organism age. While naive T cells appear epigenetically young, memory T cells and T-ALL leukemia can exhibit epigenetic ages exceeding the organismal lifespan ..read more
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Estrogen counteracts age-related decline in beige adipogenesis through the NAMPT-regulated ER stress response
Nature Aging
by Jooman Park, Ruoci Hu, Yanyu Qian, Shaolei Xiong, Asma Sana El-Sabbagh, Meram Ibrahim, Jaden Wang, Ziqiao Xu, Zhengjia Chen, Qing Song, Zhenyuan Song, Gege Yan, Abeer M. Mahmoud, Yanlin He, Brian T. Layden, Jiwang Chen, Sang-Ging Ong, Pingwen Xu, Yuwei Jiang
1w ago
Nature Aging, Published online: 10 June 2024; doi:10.1038/s43587-024-00633-z Thermogenic beige adipose tissue can enhance energy expenditure and improve metabolism, but its formation declines with age. Park, Hu et al. show that replenishing estrogen can restore cold-induced beige adipogenesis by regulating NAMPT-controlled ER stress ..read more
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SGLT2 regulates immune-mediated senolysis
Nature Aging
by Guangran Guo, Corina Amor
1w ago
Nature Aging, Published online: 10 June 2024; doi:10.1038/s43587-024-00651-x Inhibitors of sodium glucose co-transporter 2 (SGLT2) have long been used in the treatment of diabetes and cardiovascular disease, owing to their modulation of glucose levels. Katsuumi and colleagues now show that, in addition to their glycemic effects, SGLT2 inhibitors modulate senescence immune surveillance by downregulating PD-L1 expression on senescent cells ..read more
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A mild increase in nutrient signaling to mTORC1 in mice leads to parenchymal damage, myeloid inflammation and shortened lifespan
Nature Aging
by Ana Ortega-Molina, Cristina Lebrero-Fernández, Alba Sanz, Miguel Calvo-Rubio, Nerea Deleyto-Seldas, Lucía de Prado-Rivas, Ana Belén Plata-Gómez, Elena Fernández-Florido, Patricia González-García, Yurena Vivas-García, Elena Sánchez García, Osvaldo Graña-Castro, Nathan L. Price, Alejandra Aroca-Crevillén, Eduardo Caleiras, Daniel Monleón, Consuelo Borrás, María Casanova-Acebes, Rafael de Cabo, Alejo Efeyan
1w ago
Nature Aging, Published online: 07 June 2024; doi:10.1038/s43587-024-00635-x Ortega-Molina et al. demonstrate that mouse models with mild, genetic overactivation of mTOR signaling develop chronic myeloid inflammation, causing reduced healthspan and lifespan, without an increase in tumor incidence ..read more
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