Nature Aging, Published online: 22 April 2024; doi:10.1038/s43587-024-00614-2 Late-onset hypogonadism (LOH) can occur with male reproductive aging and is characterized by declining testosterone levels as well as other clinical symptoms. Here the authors show that dysregulated phago-/auto-lysosomes in Sertoli cells are a key feature of LOH, linking metabolism and aging, and that pharmaceutical targeting of lysosome dysfunction can alleviate LOH in mice ..read more

Nature Aging, Published online: 19 April 2024; doi:10.1038/s43587-024-00611-5 The advent of plaque-clearing antibodies to the amyloid-β as the first disease-modifying treatment for Alzheimer’s disease will change the course of this disease, the most common type of dementia. Related progress will gradually alter the trajectory of human aging ..read more

Nature Aging, Published online: 17 April 2024; doi:10.1038/s43587-024-00609-z He et al. characterizes a role of microcephalin (MCPH1), a known regulator of DNA damage response, in hematopoietic stem cell (HSC) aging demonstrating nuclear MCPH1 translocation that leads to activation of necroptosis and deterioration of HSC function with age ..read more

Nature Aging, Published online: 16 April 2024; doi:10.1038/s43587-024-00612-4 Circulating factors have an important role in aging. Here the authors show that small extracellular vesicles derived from young plasma rejuvenate whole-body physiology in aged mice, at least in part, by stimulating PGC-1α expression and improving mitochondrial energy metabolism ..read more

Nature Aging, Published online: 15 April 2024; doi:10.1038/s43587-024-00597-0 Wu et al. explore vaccine strategies targeting age-related diseases, as well as senescent cells specifically, as potential underlying drivers of aging itself. They discuss challenges faced in clinical trials, as well as further optimizations required to increase therapeutic efficacy ..read more

Nature Aging, Published online: 12 April 2024; doi:10.1038/s43587-024-00595-2 Aging dynamics of complex lipids are incompletely understood. Here Janssens and colleagues describe lipids that change with age across ten tissues in mice. Notably, bis(monoacylglycerol)phosphate accumulated with age. This lipid also accumulated in muscle of older humans, and reduced upon a short bout of exercise ..read more

Nature Aging, Published online: 12 April 2024; doi:10.1038/s43587-024-00610-6 Lipid changes across the lifespan and their role in health and longevity are incompletely understood. Here, Tsugawa and colleagues conduct untargeted lipidomics across 13 sample types and four ages in mice, considering sex and microbiome dependencies. This study provides a comprehensive resource of lipid changes with aging and highlights regulatory metabolic components, such as the enzyme UGT8, as potentially responsible for male-specific glycolipid biosynthesis in the kidney ..read more

Nature Aging, Published online: 09 April 2024; doi:10.1038/s43587-024-00607-1 Ovarian aging has an important role in health and fertility; however, the molecular mechanisms underlying it remain incompletely understood. Here the authors use single-cell and spatial transcriptomics in reproductively young, middle-aged and older human ovarian tissue to elucidate ovarian aging. They describe spatiotemporal changes in ovarian cells and highlight the important regulatory role of FOXP1 ..read more

Nature Aging, Published online: 09 April 2024; doi:10.1038/s43587-024-00618-y Staging Alzheimer’s disease on the basis of the disease’s biological underpinnings might help with stratification and prognostication, both in the clinical setting and in clinical trials. We propose a staging model based on only five biomarkers, which are related to amyloid-β and tau pathologies in different ways and can be measured with a single sample of cerebrospinal fluid ..read more

Nature Aging, Published online: 09 April 2024; doi:10.1038/s43587-024-00623-1 Unexpectedly high cardiovascular disease risk in extreme poverty ..read more