Age-associated PDGF-C drives breast cancer metastatic relapse
Nature Aging
by Yahyah Aman
4d ago
Nature Aging, Published online: 30 May 2023; doi:10.1038/s43587-023-00437-7 Age-associated PDGF-C drives breast cancer metastatic relapse ..read more
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Human microglia show unique transcriptional changes in Alzheimer’s disease
Nature Aging
by Katherine E. Prater, Kevin J. Green, Sainath Mamde, Wei Sun, Alexandra Cochoit, Carole L. Smith, Kenneth L. Chiou, Laura Heath, Shannon E. Rose, Jesse Wiley, C. Dirk Keene, Ronald Y. Kwon, Noah Snyder-Mackler, Elizabeth E. Blue, Benjamin Logsdon, Jessica E. Young, Ali Shojaie, Gwenn A. Garden, Suman Jayadev
4d ago
Nature Aging, Published online: 29 May 2023; doi:10.1038/s43587-023-00424-y Microglia, the innate immune cells of the brain, exhibit diverse functions and can influence Alzheimer’s disease progression. This study explores human microglial diversity in Alzheimer’s disease, uncovering unique disease-associated microglial populations and predicting underlying gene regulatory networks ..read more
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Senescence-induced immune remodeling facilitates metastatic adrenal cancer in a sex-dimorphic manner
Nature Aging
by Kate M. Warde, Lorenzo J. Smith, Lihua Liu, Chris J. Stubben, Brian K. Lohman, Parker W. Willett, Julia L. Ammer, Guadalupe Castaneda-Hernandez, Sikiru O. Imodoye, Chenge Zhang, Kara D. Jones, Kimber Converso-Baran, H. Atakan Ekiz, Marc Barry, Michael R. Clay, Katja Kiseljak-Vassiliades, Thomas J. Giordano, Gary D. Hammer, Kaitlin J. Basham
4d ago
Nature Aging, Published online: 25 May 2023; doi:10.1038/s43587-023-00420-2 The mechanisms underlying the influence of aging on cancer are incompletely understood. Warde et al. establish a new model of age- and sex-dependent adrenal cancer. Their work uncovers a tumor-protective role for myeloid immune cells that is enhanced by androgens ..read more
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The promise of AI and technology to improve quality of life and care for older adults
Nature Aging
by Peter M. Abadir, Rama Chellappa, Niteesh Choudhry, George Demiris, Deepak Ganesan, Jason Karlawish, Rose M. Li, Jason H. Moore, Jeremy D. Walston, Benjamin Marlin, Najim Dehak, Alicia I. Arbaje, Mathias Unberath, Thomas K. M. Cudjoe, Suchi Saria, Esther Oh, Nancy Lundebjerg, Christopher G. Chute, Phillip Phan, Quincy Samus, Nancy L. Schoenborn
4d ago
Nature Aging, Published online: 25 May 2023; doi:10.1038/s43587-023-00430-0 The promise of AI and technology to improve quality of life and care for older adults ..read more
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Follicular communication breakdown in aging ovaries
Nature Aging
by Cecilia S. Blengini, Karen Schindler
4d ago
Nature Aging, Published online: 25 May 2023; doi:10.1038/s43587-023-00435-9 Liu and colleagues investigate the effects that ovarian aging may have in granulosa cell-to-oocyte communication and demonstrate that oocyte rejuvenation and the extension of reproductive lifespan is possible by increasing lipid metabolism in granulosa cells in mouse ..read more
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Immunovirological and environmental screening reveals actionable risk factors for fatal COVID-19 during post-vaccination nursing home outbreaks
Nature Aging
by Lize Cuypers, Els Keyaerts, Samuel Leandro Hong, Sarah Gorissen, Soraya Maria Menezes, Marick Starick, Jan Van Elslande, Matthias Weemaes, Tony Wawina-Bokalanga, Joan Marti-Carreras, Bert Vanmechelen, Bram Van Holm, Mandy Bloemen, Jean-Michel Dogne, François Dufrasne, Keith Durkin, Jean Ruelle, Ricardo De Mendonca, Elke Wollants, Pieter Vermeersch, Ruddy Wattiez, Michael Peeters, Kate Bakelants, Sarah Denayer, François E. Dufrasne, Cécile Meex, Laurent Gillet, Maria Artesi, Marie-Pierre Hayette, Sébastien Bontems, Vincent Bours, Claire Gourzonès, Olivier Ek, Fabrice Bureau, Benoit Kabamba, Jean-Luc Gala, Bertrand Bearzatto, Jérôme Ambroise, Arnaud Marchant, Coralie Henin, Benoit Haerlingen, Ricardo de Mendonca, Marie-Luce Delforge, Carl Vael, Lynsey Berckmans, Philippe Selhorst, Kevin K. Ariën, Sonia Van Dooren, Bruno Hinckel, Hideo Imamura, Toon Janssen, Ben Caljon, Oriane Soetens, Denis Piérard, Thomas Demuyser, Charlotte Michel, Olivier Vandenberg, Sigi van den Wijngaert, Giulia Zorzi, Philippe Van Lint, Walter Verstrepen, Reinout Naesens, Sarah Van Lent, Pascale Hilbert, Sylvain Brohée, Pierre-Emmanuel Léonard, Deniz Karadurmus, Jeremie Gras, Damien Féret, Barbara Lambert, Anne Vankeerberghen, Astrid Holderbeke, Hans De Beenhouwer, Lien Cattoir, Christine Lammens, Basil Britto Xavier, Marie Le Mercier, Jasmine Coppens, Veerle Matheeussen, Herman Goossens, Geert A. Martens, Koen Swaerts, Frederik Van Hoecke, Dieter Desmet, Patrick Descheemaeker, Pierre Bogaerts, Jonathan Degosserie, Olivier Denis, Te-Din Huang, Dagmar Obbels, Hanne Valgaeren, Johan Frans, Annick Smismans, Paul-Emile Claus, Denise Veltman, Truus Goegebuer, Ann Lemmens, Bea Van den Poel, Sonja De Bock, Wim Laffut, Ellen Van Even, Jos Van Acker, Charlotte Verfaillie, Elke Vanlaere, Klara De Rauw, Luc Waumans, Britt Van Meensel, Reinoud Cartuyvels, Marijke Raymaekers, Bruno Verhasselt, Jorn Hellemans, Merijn Vanhee, Marijke Reynders, Caroline Boulouffe, Achille Djiena, Caroline Broucke, Boudewijn Catry, Katrien Lagrou, Marc Van Ranst, Johan Neyts, Guy Baele, Piet Maes, Emmanuel André, Simon Dellicour, Johan Van Weyenbergh
4d ago
Nature Aging, Published online: 22 May 2023; doi:10.1038/s43587-023-00421-1 Although vaccination drops COVID-19 mortality in older adults, post-vaccine fatal COVID-19 in nursing home outbreaks was linked to Delta, Gamma and Mu variants, persistently detected in aerosols. Mortality was predicted by IFNB1 or age, ORF7a and ACE2 mRNAs ..read more
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Reply to: Comparator choices in pharmacoepidemiology studies of Alzheimer’s disease
Nature Aging
by Pengyue Zhang, Yuan Hou, Chien-Wei Chiang, Andrew A. Pieper, Jeffrey Cummings, Feixiong Cheng
4d ago
Nature Aging, Published online: 22 May 2023; doi:10.1038/s43587-023-00418-w Reply to: Comparator choices in pharmacoepidemiology studies of Alzheimer’s disease ..read more
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Comparator choices in pharmacoepidemiology studies of Alzheimer’s disease
Nature Aging
by Qoua L. Her, Jacob C. Kahrs, Til Stürmer
4d ago
Nature Aging, Published online: 22 May 2023; doi:10.1038/s43587-023-00417-x Comparator choices in pharmacoepidemiology studies of Alzheimer’s disease ..read more
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New mass spectrometry method to simultaneously quantify several tau species in blood
Nature Aging
by
2w ago
Nature Aging, Published online: 19 May 2023; doi:10.1038/s43587-023-00434-w Quantification of tau peptides in blood samples using a new mass spectrometry method suggests that individual phosphorylated tau peptides have distinct patterns of emergence in Alzheimer’s disease and differential associations with amyloid and tau pathologies. This method has the potential to stage patients along the disease continuum and for clinical trials ..read more
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Blood biomarkers for Alzheimer’s disease in clinical practice and trials
Nature Aging
by Oskar Hansson, Kaj Blennow, Henrik Zetterberg, Jeffrey Dage
2w ago
Nature Aging, Published online: 18 May 2023; doi:10.1038/s43587-023-00403-3 This Review provides an update on the most promising blood-based biomarkers relevant to Alzheimer’s disease and how they can be used to substantially improve the diagnostic and prognostic work-up in clinical practice and trials ..read more
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