Robust immunity conferred by combining COVID-19 vaccine platforms in older adults
Nature Aging
by Carolien E. van de Sandt, Katherine Kedzierska
1d ago
Nature Aging, Published online: 12 July 2024; doi:10.1038/s43587-024-00668-2 SARS-CoV-2 infections are typically more severe with increased age. Vaccination can reduce morbidity and mortality, but the age-associated decline in immune function could limit vaccine efficacy in older adults. Dallan, Proietto and colleagues demonstrate robust immunological humoral and cellular memory in older adults who received primary vaccinations using the adenoviral platforms and received subsequent boosting with mRNA vaccine platforms ..read more
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Blood protein assessment of leading incident diseases and mortality in the UK Biobank
Nature Aging
by Danni A. Gadd, Robert F. Hillary, Zhana Kuncheva, Tasos Mangelis, Yipeng Cheng, Manju Dissanayake, Romi Admanit, Jake Gagnon, Tinchi Lin, Kyle L. Ferber, Heiko Runz, Christopher N. Foley, Riccardo E. Marioni, Benjamin B. Sun
5d ago
Nature Aging, Published online: 10 July 2024; doi:10.1038/s43587-024-00655-7 Gadd et al. identify proteins circulating in the blood that can stratify the risk people have of developing a range of leading age-related diseases, up to a decade before onset ..read more
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Protein-based risk score improves prediction of hip fractures
Nature Aging
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5d ago
Nature Aging, Published online: 10 July 2024; doi:10.1038/s43587-024-00680-6 Identification of patients at risk for hip fracture is crucial to inform intervention strategies. We developed a plasma protein-based risk score for hip fracture and validated this score in three independent cohorts using two substantially different proteomics platforms. The protein-based risk score, but not available polygenic risk scores, improved hip fracture discrimination ..read more
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A distinct aging-enriched platelet differentiation pathway
Nature Aging
by Anna Kriebs
5d ago
Nature Aging, Published online: 09 July 2024; doi:10.1038/s43587-024-00677-1 A distinct aging-enriched platelet differentiation pathway ..read more
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Pharmacological TERT activation attenuates phenotypes of natural aging
Nature Aging
by Hannah Walters
5d ago
Nature Aging, Published online: 08 July 2024; doi:10.1038/s43587-024-00673-5 Pharmacological TERT activation attenuates phenotypes of natural aging ..read more
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Immune-checkpoint blockade protects aged mice from infection
Nature Aging
by Daniel Thiele, Nicole L. La Gruta
5d ago
Nature Aging, Published online: 08 July 2024; doi:10.1038/s43587-024-00664-6 A study demonstrates the efficacy of immune-checkpoint blockade in prolonging survival and boosting CD8+ T cell function in aged mice after pathogen exposure. These findings highlight how aging-related immune changes may lead to augmented CD8+ T cell responses to checkpoint blockade, which results in improved protection from infection. The findings also highlight the importance of understanding immune aging in future efforts to target immunotherapies to older adults ..read more
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A deep learning model accurately predicts 1-year mortality but at the risk of unfairness
Nature Aging
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1w ago
Nature Aging, Published online: 02 July 2024; doi:10.1038/s43587-024-00665-5 A deep learning model accurately predicts 1-year mortality for the entire Finnish population. Despite robust performance and potential as a digital marker of aging, fairness analyses reveal prediction disparities, so integration into public health should be approached cautiously ..read more
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Targeting senescence induced by age or chemotherapy with a polyphenol-rich natural extract improves longevity and healthspan in mice
Nature Aging
by Sara Zumerle, Miles Sarill, Miriam Saponaro, Manuel Colucci, Liliana Contu, Edoardo Lazzarini, Roberta Sartori, Camilla Pezzini, Anna Rinaldi, Anna Scanu, Jacopo Sgrignani, Patrizia Locatelli, Marianna Sabbadin, Aurora Valdata, Daniela Brina, Isabella Giacomini, Beatrice Rizzo, Alessandra Pierantoni, Saman Sharifi, Silvia Bressan, Claudia Altomare, Yulia Goshovska, Chiara Giraudo, Roberto Luisetto, Luca Iaccarino, Cristina Torcasio, Simone Mosole, Emiliano Pasquini, Andrea Rinaldi, Laura Pellegrini, Gregorio Peron, Matteo Fassan, Stefano Masiero, Andrea Maria Giori, Stefano Dall’Acqua, Johan Auwerx, Pietro Cippà, Andrea Cavalli, Marco Bolis, Marco Sandri, Lucio Barile, Monica Montopoli, Andrea Alimonti
2w ago
Nature Aging, Published online: 01 July 2024; doi:10.1038/s43587-024-00663-7 Botanical extracts offer a valuable resource for identifying therapies. Zumerle, Sarill et al. show that a standardized extract of Salvia haenkei extends lifespan and healthspan in naturally aged mice by modulating inflammation and cellular senescence, and identify the constituent component luteolin as a senomorphic that disrupts the p16–CDK6 interaction ..read more
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Adherence to the planetary health diet and cognitive decline: findings from the ELSA-Brasil study
Nature Aging
by Natalia Gomes Gonçalves, Leandro Teixeira Cacau, Naomi Vidal Ferreira, Paulo Andrade Lotufo, Alessandra Carvalho Goulart, Maria Carmen Viana, Sandhi Maria Barreto, Isabela Martins Bensenor, Dirce Maria Marchioni, Claudia Kimie Suemoto
2w ago
Nature Aging, Published online: 28 June 2024; doi:10.1038/s43587-024-00666-4 Using longitudinal data from the ELSA-Brasil study, Gonçalves et al. report that income is a barrier to how adherence to the sustainable planetary health diet is linked to slower cognitive decline ..read more
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The genetic architecture of biological age in nine human organ systems
Nature Aging
by Junhao Wen, Ye Ella Tian, Ioanna Skampardoni, Zhijian Yang, Yuhan Cui, Filippos Anagnostakis, Elizabeth Mamourian, Bingxin Zhao, Arthur W. Toga, Andrew Zalesky, Christos Davatzikos
2w ago
Nature Aging, Published online: 28 June 2024; doi:10.1038/s43587-024-00662-8 Using machine learning techniques applied to multimodal UK Biobank data, Wen et al. characterize the genetic basis of the biological age gaps of individual organs, uncovering interorgan cross-talk and links between chronic diseases, lifestyle factors and biological age gaps ..read more
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