Jiayi Wu, Wei Tang, Kai Zhang, Kai Li, Jianwen Wang, Youjia Yu, Feng Chen Journal of Forensic Science and Medicine 2022 8(4):190-193 Identification of sudden cardiac death (SCD) with a structurally normal heart remains an important challenge in forensic pathology. Long QT syndrome (LQTS) is known as an inherited or acquired channelopathy, which is characterized with prolonged QT interval, and is likely to cause SCD in young adults. In this circumstance, no specific pathological change in the heart can be found anatomically or histologically in the LQTS victims. Thus, postmortem LQTS diagnosi ..read more

Ye Wang, Jie Wang, Li Hu, Shuainan Huang, Yue Cao, Youjia Yu, Feng Chen Journal of Forensic Science and Medicine 2022 8(4):170-178 Sudden cardiac death (SCD) is a common cause of death due to the high prevalence and mortality of cardiovascular disease (CVD). Currently, the forensic identification of SCD relies on traditional histomorphological examination, lacking stable biomarkers with high specificity and sensitivity. Previous studies have shown that exosomes (Exos) are ideal vectors and the application of Exos provides novel insight as the diagnostic biomarkers and treatment of CVD, and i ..read more

Wenzhao Wei, Ying Fang, Nan Zhou, Qiuping Wu, Qianhao Zhao, Jianding Cheng Journal of Forensic Science and Medicine 2022 8(4):179-185 Sudden cardiac death (SCD), accounting for a substantial part of the forensic autopsy, is a leading cause of mortality worldwide. Lethal arrhythmia due to sodium channel diseases is recognized as one of the most prevalent etiologies of SCD. In these disorders, defective cardiomyocytes, including the pacemaker and the working cardiomyocytes, would manifest as abnormal electrical activity and morphology, thereby predisposing individuals to SCD. It is always a pr ..read more

Allen Burke Journal of Forensic Science and Medicine 2022 8(4):157-169 Sudden cardiac death (SCD) is an unexpected cardiac death that is instantaneous or occurs within a short period of time after onset of symptoms, in a person in a stable state of health. SCD has either a certain etiology (for example, cardiac tamponade or fresh occlusive coronary thrombus), or has one or more morphologic substrates that increase the risk of electrical instability that in turn can lead to a fatal arrhythmia. The latter group of SCD has been assigned as either highly probable or uncertain etiologies, accordi ..read more

Ningguo Liu, Mingzhen Yang, Zhling Tian, Hewen Dong, Yang Lu, Donghua Zou, Yanbin Wang Journal of Forensic Science and Medicine 2022 8(4):149-156 Postmortem imaging (PMI) technology known as virtual autopsy or virtopsy is regarded as a useful method of noninvasive or minimally invasive autopsy in forensic practice. Postmortem computed tomography is applicable to traumatic investigation, acute hemorrhage, pulmonary parenchyma disease, calcification (calculus, atherosclerosis), and gas accumulation. Postmortem magnetic resonance (PMMR) has been proven to have advantages in soft tissue identifi ..read more

Xingyu Ma, Yeming Li, Ya Xi, Liyang Su, Yuxing Tong, Chun Wang, Tianshui Yu, Dong Zhao Journal of Forensic Science and Medicine 2022 8(4):142-148 Background: Accumulated studies have demonstrated that Kruppel-like factor 5 (KLF5), a transcription factor, plays an important role in regulating cell proliferation and tissue remodeling through the expression of its downstream genes. KLF5-related factors are expected to be involved in the healing process after myocardial injury or myocardial ischemic changes, especially for the forensic diagnosis of myocardial ischemic physiopathology. Aim and Ob ..read more

Dong Zhao, Feng Chen Journal of Forensic Science and Medicine 2022 8(4):133-134 ..read more

Pathum Sookaromdee, Viroj Wiwanitkit Journal of Forensic Science and Medicine 2022 8(3):131-131 ..read more

Chong Wang, Hemiao Zhao, Qingzhen Meng, Hui Sun, Xiulan Xu, Wanshui Li Journal of Forensic Science and Medicine 2022 8(3):118-122 Body fluid identification through messenger RNA (mRNA) has been proposed as a useful supplement to presumptive and confirmatory tests by previous laboratory studies; however, its application in routine clinical forensic examination was rare. We report a case of sexual assault in which body fluid identification by mRNA profiling was used. Vaginal secretions mRNA markers (MUC4, HBD1, and CYP2B7P1) were used to test the sample, being obtained positive results. This c ..read more

Shicheng Hao, Yan Liu, Yan Xu, Dong Zhao, Gexin Liu, Jinpei Zhang, Li Yuan Journal of Forensic Science and Medicine 2022 8(3):123-130 To investigate the genetic polymorphisms of 19 X-STR loci in the Han population in Northern China, samples from 628 unrelated individuals (314 males and 314 females) were collected and 19 X-STR loci were amplified by AGCU X19 STR System. A total of 270 different alleles were detected in 19 X-STR loci. All loci were in Hardy − Weinberg equilibrium and there was only one pair of linkage loci (DXS10103-DXS10101). There was no significant difference in a ..read more