Lipogenesis and local prenylation drive invasion
Journal of Cell Biology (JCB) | Rockefeller University Press
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6d ago
Invasive cells form large, specialized protrusions to break through basement membrane (BM) matrix barriers. Park et al. reveal a crucial requirement for de novo lipid synthesis and a dynamic polarizing prenylation system to rapidly construct invasive protrusions that breach BMs ..read more
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Mmp14 regulates dermal fibroblast function
Journal of Cell Biology (JCB) | Rockefeller University Press
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6d ago
Dermal fibroblasts actively remodel pericellular type I collagen during early postnatal development. Sabeh et al. demonstrate that the membrane-anchored matrix metalloproteinase, Mmp14, serves as a requisite cell-survival factor by hydrolyzing collagen and activating β1 integrin, thereby suppressing aberrant activation of a TGF-β1/JNK-dependent apoptosis program in vivo ..read more
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UL14 is protected by Bcp1 and Rkm1
Journal of Cell Biology (JCB) | Rockefeller University Press
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6d ago
Yeh et al. have revealed the molecular mechanism by which the ribosomal protein uL14 is protected by its dedicated chaperone and the methyltransferase. This dual protection system sequentially delivers uL14, ensuring its quality and safety from the cytoplasm until its incorporation into the pre-60S ribosome ..read more
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UBAP2L modulates PB formation and SG association
Journal of Cell Biology (JCB) | Rockefeller University Press
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6d ago
Riggs et al. characterize the RNA binding protein Ubiquitin Associated Protein 2-Like (UBAP2L) and its role in stress-responsive biomolecular condensates, stress granules and p-bodies. They find that UBAP2L contributes to PB biogenesis and SG–PB interactions, in addition to SG formation ..read more
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Pak1 removal drives Cdc42 oscillations
Journal of Cell Biology (JCB) | Rockefeller University Press
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6d ago
Cdc42 regulates growth in most eukaryotes and must be cyclically activated and inactivated at sites of growth. We show that endocytosis allows inactivated sites to regain activity by removing the negative feedback (Pak1 kinase) from cell ends ..read more
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TLNRD1 regulates endothelial barrier integrity
Journal of Cell Biology (JCB) | Rockefeller University Press
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6d ago
Ball and Ghimire et al. identified that the actin-bundling protein TLNRD1 is an integral component of the CCM complex, specifically binding to CCM2. The TLNRD1–CCM2 interaction is pivotal for maintaining endothelial barrier integrity, offering new insights into CCM-related diseases ..read more
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ESCRT regulation of synaptic extracellular vesicles
Journal of Cell Biology (JCB) | Rockefeller University Press
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1M ago
ESCRT depletion disrupts synaptic extracellular vesicle (EV) release without affecting signaling by several EV cargoes. EVs are phagocytosed by adjacent cells, and ESCRT disruption causes compensatory autophagy. These results suggest that EV release serves proteostatic rather than intercellular signaling functions for these cargoes at synapses ..read more
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Visualizing IFT in beating flagella
Journal of Cell Biology (JCB) | Rockefeller University Press
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1M ago
We used high-frame-rate, dual-color fluorescence microscopy to visualize IFT trafficking in the beating flagella of , a uniflagellate human parasite. This revealed differing sensitivity of IFT train speed to genetically induced, mechanical, and natural changes in beating ..read more
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SHH-EP4 crosstalk stabilizes ciliary length
Journal of Cell Biology (JCB) | Rockefeller University Press
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1M ago
This study reveals crosstalk between Sonic Hedgehog (SHH) and prostaglandin signaling pathways. SHH signaling leads to the secretion of PGE2, which activates the ciliary EP4 receptor to promote primary cilium length stability. Disruption of SHH-to-EP4 communication leads to primary cilium shortening and reduced SHH signal output ..read more
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DBF4 drives CDC7 activity in human DNA replication
Journal of Cell Biology (JCB) | Rockefeller University Press
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1M ago
In human cells, the S-phase-promoting kinase CDC7 exists in two alternative complexes: CDC7-DBF4 or CDC7-DRF1. Here, Göder et al. show that while CDC7’s essential function can be supported by both subunits, DBF4 is the primary mediator of CDC7 activity during DNA replication ..read more
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