Journal of Cell Biology (JCB) | Rockefeller University Press
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The Journal of Cell Biology publishes peer-reviewed research on all aspects of cellular structure and function. Stay tuned to get the latest updates.
Journal of Cell Biology (JCB) | Rockefeller University Press
1w ago
Pleiner, Hazu, Pinton Tomaleri et al. identify a selectivity filter in the ER membrane protein complex (EMC) and show that the EMC protects the integrity of the ER proteome by limiting the misinsertion of mitochondrial tail-anchored proteins and enforcing the correct topology of multipass membrane proteins ..read more
Journal of Cell Biology (JCB) | Rockefeller University Press
1w ago
Rouaud et al. show that cingulin and paracingulin bind to specific myosin-2 isoforms through coiled-coil rod-mediated interactions and tether them to junctions to transmit force and modulate ZO-1 junctional accumulation, tight junction membrane tortuosity, apical membrane stiffness, and junctional architecture ..read more
Journal of Cell Biology (JCB) | Rockefeller University Press
1w ago
Gáspár et al. reveal that sequential activity of dynein and kinesin-1 motors during transport of mRNA to the posterior of the oocyte is orchestrated by competition between two double-stranded RNA-binding proteins, Egl and Staufen, and that this process is spatio-temporally controlled by dynein-mediated localization of the ..read more
Journal of Cell Biology (JCB) | Rockefeller University Press
1w ago
Shelke et al. show that disruption of the BORC–ARL8–HOPS pathway increases exosome secretion by impairing fusion of multivesicular endosomes with lysosomes, and thus increasing the availability of intraluminal vesicles for release into the extracellular space ..read more
Journal of Cell Biology (JCB) | Rockefeller University Press
1w ago
Yang et al. reveal an autoinhibitory mechanism of the centrosomin motif 1 and the relief of the autoinhibition by phosphorylation. This autoinhibition plays a role in controlling microtubule nucleation on centrosomes and the Golgi complex, and it also regulates centrosome positioning, Golgi assembly, and cell polarization ..read more
Journal of Cell Biology (JCB) | Rockefeller University Press
1w ago
Hakanpää et al. show that reticular adhesions are assembled at flat clathrin lattices, a process inhibited by fibronectin and its receptor, integrin α5β1. This novel adhesion assembly mechanism is coupled to cell migration and reveals a unique crosstalk between cell-matrix adhesions ..read more
Journal of Cell Biology (JCB) | Rockefeller University Press
3w ago
Amm et al. define an amphipathic helix in Ndc1, an essential nuclear pore and spindle pole body transmembrane protein, genetically interacting with similar motifs in Nup53 and Nup59. This work suggests that the nuclear pore formation depends on a balance between amphipathic motifs in different nucleoporins ..read more
Journal of Cell Biology (JCB) | Rockefeller University Press
3w ago
Meng et al. report that upon plasma membrane damage in a cell, the Golgi apparatus accumulates at the wound site and facilitates membrane repair by converting PtdIns4P to PtdIns(4,5)P2 in . This finding advances our understanding of cellular survival mechanisms under mechanical stress ..read more
Journal of Cell Biology (JCB) | Rockefeller University Press
3w ago
Peker et al. identified a two-step import pathway allowing for dual protein localization to matrix and IMS. Weak targeting signals allow proteins to acquire stabilizing disulfide bonds in the IMS en route to the matrix. This pathway allows the sensing of import activity in two compartments ..read more
Journal of Cell Biology (JCB) | Rockefeller University Press
3w ago
Nuclear envelope (NE) budding is a nuclear export pathway for large macromolecular machineries. Davidson et al. show that the Centralspindlin proteins Pav and Tum work in two different nuclear WASH complexes to regulate the physical machineries of NE budding ..read more