Journal of Cell Biology (JCB) | Rockefeller University Press
1,301 FOLLOWERS
The Journal of Cell Biology publishes peer-reviewed research on all aspects of cellular structure and function. Stay tuned to get the latest updates.
Journal of Cell Biology (JCB) | Rockefeller University Press
1w ago
Robinson et al. investigate AP-1 function using complementary approaches on cells coexpressing tagged AP-1 and cargo proteins. Their results support a model in which AP-1 is recruited onto post-Golgi carriers and early/recycling endosomes, where it retrieves selected proteins back to the TGN ..read more
Journal of Cell Biology (JCB) | Rockefeller University Press
1w ago
Houston et al. show that in , BUB-1–BUB-3 kinetochore localization requires recognition of phosphorylated “TF” motifs in KNL-1 by the TPR domain of BUB-1. BUB-3 binding to phosphorylated “MELT” motifs in KNL-1 cooperates with the TPR to rapidly increase complex localization during mitotic entry ..read more
Journal of Cell Biology (JCB) | Rockefeller University Press
1w ago
How the ER stress sensor IRE1α detects misfolded proteins to activate the unfolded protein response is not fully defined. Simpson et al. find that IRE1α binds a metastable structural motif in cholera toxin and other proteins that activate the UPR with implications for how binding may be linked to IRE1α activation ..read more
Journal of Cell Biology (JCB) | Rockefeller University Press
1w ago
Maib et al. present a toolbox of recombinant biosensors for the multiplex and super-resolution detection of phosphoinositides, a small family of signaling lipids. Detection of these crucial lipids in fixed cells and tissues will enable researchers to address key outstanding questions in cell biology ..read more
Journal of Cell Biology (JCB) | Rockefeller University Press
1w ago
Li et al. reveal that liquid–liquid phase separation of host fragile X–related (FXR) family proteins drives clustering of replication organelles of SARS-CoV-2 via specific interaction with viral nonstructural protein Nsp3. FXRs further recruit translation machinery to facilitate viral protein translation for efficient viral replication ..read more
Journal of Cell Biology (JCB) | Rockefeller University Press
1w ago
Hegde et al. report that extracellular Caspase-1 functions as a chemotactic factor. This work solves the long-standing question of the cue(s) that coax the migration of HFSCs into the epidermis during the wound healing response and inflammatory skin conditions ..read more
Journal of Cell Biology (JCB) | Rockefeller University Press
1w ago
Centromeric DNA regions are highly diverse and evolve rapidly. Chen et al. investigate how the correct balance of centromeric transcripts from mouse stem cells affects chromatin recruitment of CENPC and propose a model where structural RNA features, rather than sequence motifs, are key for RNA–protein interactions ..read more
Journal of Cell Biology (JCB) | Rockefeller University Press
1M ago
The study uncovers the pivotal role of PCIF1-mediated m Am RNA modification in ciliogenesis. PCIF1 negatively regulates ciliation by modulating BICD2 protein levels via m Am catalytic activity, influencing mRNA stability and translation efficiency. These findings elucidate a fundamental mechanism in ciliogenesis regulation ..read more
Journal of Cell Biology (JCB) | Rockefeller University Press
1M ago
Füllbrunn et al. show that the Rab7/Ypt7-specific GTPase activating protein Gyp7 localizes to endosomes, where it is required for Ypt7 regulation. Manipulation of Gyp7 affects both Ypt7 localization and TORC1 signaling, suggesting a link between the endosomal Ypt7 pool and nutrient signaling ..read more
Journal of Cell Biology (JCB) | Rockefeller University Press
1M ago
Tight junction membrane proteins, claudins, JAM, and CAR, coordinately regulate the nanometer-scale organization of ZO-1 molecules and are required for the mechanical resistance of apical junctions in epithelial cells ..read more