Nature » Cancer
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Nature Cancer aims to publish the most significant advances across the full spectrum of cancer research in the life, physical, applied and social sciences, spanning basic preclinical, translational and clinical work. The journal's broad scope covers all cancer research offering new insights into cancer biology and genetics, new approaches for the development and delivery of diagnostics and..
Nature » Cancer
7h ago
Nature Cancer, Published online: 24 April 2024; doi:10.1038/s43018-024-00749-6
In this phase 1 trial, Hegde et al. treat 13 individuals with advanced sarcoma with lymphodepletion followed by HER2-specific CAR T cells, which were found to be safe and showed antitumor activity ..read more
Nature » Cancer
5d ago
Nature Cancer, Published online: 19 April 2024; doi:10.1038/s43018-024-00763-8
Merz and colleagues perform single-cell multiomic analysis of mononuclear cells isolated from individuals receiving BCMA-directed CAR T cell therapy for myeloma and show that nonresponders are characterized by an immune-suppressive microenvironment ..read more
Nature » Cancer
6d ago
Nature Cancer, Published online: 18 April 2024; doi:10.1038/s43018-024-00761-w
Lawson et al. show that genetic inactivation of Phd1 or Phd2 hinders progression of AML and compromises leukemic stem cells. They develop a selective PHD inhibitor IOX5 and show therapeutic efficacy in AML, which can be potentiated with venetoclax ..read more
Nature » Cancer
6d ago
Nature Cancer, Published online: 18 April 2024; doi:10.1038/s43018-024-00756-7
Sinha and colleagues present PERCEPTION, a precision oncology computational pipeline that can predict the response and resistance of patients by analyzing single-cell transcriptomic data from their tumor samples ..read more
Nature » Cancer
1w ago
Nature Cancer, Published online: 15 April 2024; doi:10.1038/s43018-024-00767-4
Author Correction: Breaking the performance ceiling for neoantigen immunogenicity prediction ..read more
Nature » Cancer
1w ago
Nature Cancer, Published online: 12 April 2024; doi:10.1038/s43018-024-00760-x
Ye and colleagues show that an oncolytic virus that delivers tumor-irrelevant bystander T cell epitopes to tumor cells can exploit the abundant population of bystander T cells in the tumor for anti-tumor immunity and potentiate cancer immunotherapy ..read more
Nature » Cancer
1w ago
Nature Cancer, Published online: 11 April 2024; doi:10.1038/s43018-024-00766-5
Author Correction: Potent suppression of neuroendocrine tumors and gastrointestinal cancers by CDH17CAR T cells without toxicity to normal tissues ..read more
Nature » Cancer
3w ago
Nature Cancer, Published online: 02 April 2024; doi:10.1038/s43018-024-00750-z
A CRISPR dropout screen for tRNA regulators identified YRDC as the top essential gene in glioblastoma stem cells. Threonine acts as a substrate of YRDC to facilitate the N6-threonylcarbamoyladenosine (t6A) tRNA modification and shift translation toward mitosis-related genes with a codon bias. Our findings support targeting glioblastoma growth by a well-tolerated dietary therapy ..read more
Nature » Cancer
3w ago
Nature Cancer, Published online: 29 March 2024; doi:10.1038/s43018-024-00737-w
A study reports that survivors of childhood cancer age faster than healthy controls and have increased risk of frailty and death; however, heterogeneity in outcomes was present, indicating inequities in risk. Knowledge about aging in high-risk groups holds the potential to identify interventions to improve survivorship outcomes ..read more
Nature » Cancer
1M ago
Nature Cancer, Published online: 27 March 2024; doi:10.1038/s43018-024-00735-y
Identifying which patients will benefit most from immune checkpoint blockade (ICB) is an important clinical challenge. A study now finds that Vδ1+ γδ T cells are associated with better response to ICB in melanoma tumors with a lower neoantigen load and shows that some effector functions of PD-1+ Vδ1+ T cells are repressed after engagement of PD-1 by PD-L1 ..read more