In 2011, the US Food and Drug Administration (FDA) announced a mandate to limit acetaminophen (paracetamol) to 325 mg/tablet in combination acetaminophen and opioid medications, with manufacturer compliance required by early 2014. In this podcast, JAMA Deputy Editor Mary M. McDermott, MD, interviews Jayme E. Locke, MD, MPH, and Babak J. Orandi, MD, PhD, about their JAMA study describing results of the FDA announcement on subsequent rates of hospitalizations for acute liver failure due to toxicity from acetaminophen-containing opioid drugs. Related Content: Association of FDA Mandate Limiting ..read more

In this JAMA author interview, Peter J. Pronovost, MD, PhD, Chief Quality & Clinical Transformation Officer, University Hospitals, Cleveland, and an internationally recognized expert in patient safety, discusses his recent article in JAMA on “Misdiagnosis in the Emergency Department.” A new report from AHRQ underscores the seriousness of this problem. Related Content: Misdiagnosis in the Emergency Department ..read more

Interview with James Stevermer, MD, MSPH, USPSTF member and coauthor of Serologic Screening for Genital Herpes Infection: US Preventive Services Task Force Reaffirmation Recommendation Statement. Hosted by JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS. Related Content: Serologic Screening for Genital Herpes Infection: US Preventive Services Task Force Reaffirmation Recommendation Statement Reducing HSV-2 Morbidity and Mortality> Reaffirmed USPSTF Recommendation Against Serologic Screening for Genital Herpes: Empowering Clinicians and Reducing Potential Harm Serologic Screening ..read more

Susanna Naggie, MD, vice dean for research at Duke University's School of Medicine, discusses the ACTIV-6 trial of fluvoxamine for outpatient treatment of COVID-19 and outlines the role of platform trials during the pandemic. Hosted by JAMA Deputy Editor and Editorial Director for Equity Preeti Malani, MD, MSJ. Related Content: Effect of Fluvoxamine vs Placebo on Time to Sustained Recovery in Outpatients With Mild to Moderate COVID-19 ..read more

In the wake of new legal challenges to race-conscious admission policies, JAMA Interim Executive Editor Gregory Curfman, MD, discusses racial and ethnic diversity in undergraduate and medical school admission policies with Roy H. Hamilton, MD, MS, from the Perelman School of Medicine, University of Pennsylvania. Related Content: Defending Racial and Ethnic Diversity in Undergraduate and Medical School Admission Policies ..read more

JAMA Deputy Editor Preeti Malani, MD, MSJ, discusses potential next-generation COVID-19 vaccines with Peter Marks, MD, PhD, director of the Center for Biologics Evaluation and Research at the US Food and Drug Administration. Related Content: Urgent Need for Next-Generation COVID-19 Vaccines ..read more

In this JAMA author interview, we speak with Robert M. Califf, MD, Commissioner of the FDA, about a remarkable advance in the technology of hearing aids. Dr Califf has done important work to secure the entry of over-the-counter hearing aids into the market, providing a less expensive alternative to traditional hearing aids. In this interview, Dr Califf tells the story of how this technology has finally been made available to the public. Related Content: Over-the-counter Hearing Aids: From Research to Policy to Practice ..read more

Interview with Chris Zielinski, Visiting Research Fellow and Faculty of Health and Wellbeing at the University of Winchester, UK, James Kigera, Editor-in-Chief, Annals of African Surgery, and James Tumwine, Editor-in-Chief, African Health Sciences, authors of COP27 Climate Change Conference—Urgent Action Needed for Africa and the World. Hosted by JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD. Related Content: COP27 Climate Change Conference—Urgent Action Needed for Africa and the World Conflict and Climate Collide to Create an Acute Hunger Crisis for an Unprecedented 345 Million Peopl ..read more

Interview with Gbenga Ogedegbe, MD, MPH, USPSTF member and coauthor of Screening for Obstructive Sleep Apnea in Adults: US Preventive Services Task Force Recommendation Statement. Hosted by JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS. Related Content: Screening for Obstructive Sleep Apnea in Adults Screening for Obstructive Sleep Apnea in Adults Screening for Obstructive Sleep Apnea in Adults Screening for Obstructive Sleep Apnea USPSTF Updates Recommendation for Obstructive Sleep Apnea Screening in Adults ..read more

Interview with Carol Mangione, MD, MSPH, USPSTF chair and coauthor of Hormone Therapy for the Primary Prevention of Chronic Conditions in Postmenopausal Persons: US Preventive Services Task Force Recommendation Statement. Hosted by JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS. Related Content: Hormone Therapy for the Primary Prevention of Chronic Conditions in Postmenopausal Persons Hormone Therapy for the Primary Prevention of Chronic Conditions in Postmenopausal Persons Menopausal Hormone Therapy for Prevention of Chronic Conditions ..read more