Old couples Image credit goes to pixa.com Cellinsight Everything about human ageing and related diseases Cross-linking theory The cross-linking theory of aging was proposed in 1942 by Johan Bjorksten. According to this theory Collagen and other proteins undergoing structural changes due to molecular cross linkage (collagen is an important body proteins comprising 30℅ of body proteins) . In the presence of oxygen glucose molecules binding to to proteins and this cross-linked proteins causing damage to cells and tissues resulting in aging. This theory is also called as glycosylation th ..read more

Cellinsight Everything about human ageing and related diseases Immortal animals Nothing is forever in this world, death is certain, one day it will visit us. But there are some creatures that never die by natural aging process. Human cells are capable of dividing only 50 times, later the cells entered the senescence stage, and this is the exact reason for aging. Any animal which is not experiencing senescence can defeat ageing, today I am going to tell about such types of animals and how they live without the fear of ageing 1. Jelly fish (Turritopsis dohrnii)  Immortal jellyfish (I ..read more

Aging- a Symbolic presentation What are The 9 hallmarks of Aging? According to the scientific world there are 9 reasons behind Aging, they are generally known as 9 Hallmarks of Aging. They are Genomic instability, Telomeres Attrition, Epigenetic Alteration, Loss of Proteostasis Deregulated Nutrient Sensing, Mitochondrial Dysfunction, Cellular senescence, Stem cells Exhaustion and Altered inter cellular Communications. genomic instability Genome is the genetical codes present in organisms. In other words genome is the complete set of DNA present in a cell. Every cell has  cop ..read more

Cellinsight.online Everything about human ageing and related diseases Old man + O2=young man      " Old man+O2=Young man" don't laugh I am not kidding you, this is the result of a new research conducted by Scientists from Tele Aviv University and Shamir Medical Center in Israel recently, and published in Aging magazine on 18th november 2020. The scientists claimed that they have managed to reverse the Aging. The scientists used Hyperbaric Oxygen chamber for conducting this experiment. The treatment inside the hyperbaric oxygen chamber is known as hyperbaric Oxygen therapy (HB ..read more

Cellinsight.online Everything about human ageing and related diseases Apoptosis and necrosis are they accelerate aging? apoptosis Apoptosis is programmed cell death. Apoptosis is a Greek word means "falling off".In a multicellular organism if cells are no longer needed,or it's DNA damaged and cannot be repaired,then the cells commits suicide by a process called programmed cell death or the Apoptosis. In human beings billions of cells die in bone marrow and intestine every hour .since 19th century scientists noticed and described about apoptosis but a clear definition was given by John Foxton K ..read more

Effects of enzymes on aging and related diseases  Enzymes How enzyme catalyze a chemical reaction Enzymes are biological catalysts, catalysts are those substances which can alter the speed of chemical reactions.There are positive and negative catalysts,positive catalysts speed up chemical reactions where as negative catalysts decreases the rate of chemical reactions.Enzymes are positive catalysts, which accelerate chemical reactions in our body.Enzymes are basically proteins,made up of long chains of amino acids.Enzymes are discovered in 1897 by a German biochemist Eduard Buch ..read more

Telomere theory of aging Telomere theory of aging was proposed by a Russian scientist A.M.Olovnikov in the year 1971.In the year 1961,an american scientist L.Hayflick  discovered that cultured human cells can only divide up to 50 times.On the basis of this discovery and it's data A.M olovnikov studied more and proposed the telomere theory of aging. According to the theory,when the telomeres (tail end of  chromosome) become too short the cells lose their ability to divide,gradually it lose its efficiency and become aged.After each and every cell division telomeres are ..read more

The free radical theory of aging Dr.Denham Herman a scientific researcher who proposed the 'free radical theory of aging' in the year 1956.according to this theory the process of aging is due to oxidative damage of cell organelles and other cytoplasmic contents by free radicals. intially it was assumed that the free radicals such as ROS(reactive oxygen species) produced during normal respiratory process.The free radical theory got more attention when researchers studied the cause of cancer ,Alzheimer disease,and heart diseases .This theory realises that old age is just another disease,our ol ..read more

NEURO ENDOCRINE THEORY OF AGING  According to Neuro endocrine theory the aging process is happening in hypothalamus,pituitary,and thyroid or the in regulatory action of these glands.Vladimer Dilman an internationally renowned endocrinologist put forward this theory in 1968.He found that there is considerable decline in the production of hormones in our body with increasing age,the secretion of thyroid,adrenel cortex,testis (males),ovary (females),pituitary (growth hormone) etc will falls.The production of aminoacids, peptides,monoamines enzymes etc also will decrease.it is also note ..read more

Protein structure  Role of protein on aging  Protein which controls the length of telomere are telomerase and a protein complex known as shelterin.a new study by Scripps Reserch Institute (TSRI) discovered a new protein named as TZAP (telomeric zinc associated protein)which decrease the length of telomeres by trimming,telomere is the clock of a biological cell,if it's length is too short the cell cannot multiply,a human cell can divide maximum 50 times,if it increase more, our life span may increase considerably. Certain proteins undergo oxidisation which are known to b ..read more