Chromium, a transition metal with profound pharmaceutical and biological implications, is involved in many pharmaceutical research processes. The following are key features: Nutritional Supplements A vital trace element, especially as Cr (III). Nutritional supplements usually contain it to enhance the action of insulin and improve glucose metabolism. Chromium picolinate is used commonly, for example in supplements meant to manage type 2 diabetes and metabolic syndrome. Pharmacokinetics and Pharmacodynamics To understand their therapeutic potential and safety profiles, studies on pharmacokineti ..read more

This article is about how to use centrifugal force to enhance innovation and efficiency. Centrifugal force is that apparent outward force acting on an object when it is in motion around a center, which can be regarded as applicable to organizational dynamics and innovation in metaphorical terms. Here’s what to expect: Centrifugal force Understanding Centrifugal Force in Context Centrifugal force refers to the force that seems to push an object away from the central part of its circular path. This force results mainly due to rotational systems and it represents an outward-force or away from the ..read more

Having the right conical flask for your experiments is essential to ensure precision, safety, and efficiency in your lab work. Here is a detailed guide to help you make the right choice by 2024: Material Glass Borosilicate Glass: It is durable against sudden heat change (thermal shock), corrosive substances’ impact and mechanical stress making it ideal for various laboratory applications. Soda-Lime Glass: It is less expensive but not highly resistant to heat or chemicals required in many experiments. Plastic Polypropylene: It can withstand most chemicals and autoclave thus best suited for b ..read more

ImaDuct Silicone Duct Hose is a high-performance flexible ducting solution offered by Ami Polymer Pvt. Ltd., designed to meet the rigorous demands of various industrial applications. This product combines the advantageous properties of silicone with advanced construction techniques to deliver exceptional performance in challenging environments. Key Features Temperature Resistance: ImaDuct silicone duct hoses are engineered to withstand extreme temperatures. They typically perform efficiently in a wide temperature range, from -60°C to +260°C (-76°F to +500°F). This makes them suitable for appli ..read more

The Threshold Limits for N-nitrosamines underscore the critical balance between safety and risk in pharmaceuticals, with a class-specific concern for highly carcinogenic compounds. Threshold Limits for N-nitrosamines Based on the Threshold of Toxicological Concern (TTC) concept described in ICH M7 (1), most mutagenic impurities are limited to a dose of 1.5 µg/day which corresponds to a 10-5 excess lifetime risk of cancer. However, N-nitrosamines belong to a class of substances that are highly carcinogenic at very low concentrations. This group of substances is called “cohort of concern” and ha ..read more

TESTA Analytical has published a new technical study that demonstrates the utility of its non-invasive liquid flowmeter for validating the performance of HPLC systems across a wide range of different solvents. HPLC separation protocols employ many different solvents to accommodate the unique properties of different analytes. Ensuring consistent elution profiles is a key requirement to ensure reproducible results. Continuous monitoring of the delivered HPLC eluent flow rate is therefore essential when permanent validation of results is desired or necessary as it is in regulated industries. Non ..read more

Cell therapy is a medical breakthrough in addressing various illnesses such as cancer, genetic disorders and immune system related diseases. However, the translation of these therapies from lab to clinical and commercial settings is obstructed by significant manufacturing challenges. This article covers the complexities of cell therapy manufacturing, highlighting some major technical, regulatory and logistical hurdles that need to be addressed if this innovative treatment approach is to be fully realized. Introduction Cell therapy refers to the administration of living cells into a patient for ..read more

To ensure that scientific experiments are conducted safely, accurately, efficiently and reproducibly, it is crucial to choose appropriate laboratory materials. This exhaustive manual includes critical points to consider when determining the right materials for use which include; their types, applications and maintenance among others. When putting up a new lab or updating existing equipment, you can make an informed choice with the help of this guide. Get to know your laboratory requirements 1.1 Determine your lab’s purpose Type of Research or Testing: Biological, chemical, medical, environmen ..read more

Silicone tubing has emerged as a versatile and essential component in various industries, renowned for its flexibility, durability, and biocompatibility. From medical devices to food processing, and aerospace to consumer electronics, silicone tubing is transforming how we approach complex challenges. This article delves into the diverse applications of silicone tubing, highlighting its unique properties that make it indispensable across different sectors. Medical and Healthcare. In the medical field, the need for reliable, sterile, and biocompatible materials is paramount. Silicone tubing mee ..read more

Quality control (QC) is crucial in product development due to health, safety, regulatory needs, and efficacy. To make QC procedures from the lab to the market more efficient requires a combination of rigorous testing using state of the art technology and strategic planning amongst other considerations for navigating drug development complexities. The Path of Quality Control from Lab-to-Market Early Development Stage During this phase, quality control (QC) requirements are well defined. This stage comprises: Pre-formulation Studies: Exploration into stability and compatibility through physical ..read more