New types of lung cells that can be infected by SARS-CoV-2 have been revealed using lab-grown mini lungs. The post Mini Lungs Reveal More Cells Susceptible to COVID-19 appeared first on Inside Precision Medicine ..read more

Compared to commercial, hospital-based antimicrobial susceptibility testing methods, this approach shortens a process that typically takes 48–72 hours to an average of about 13 hours (according to simulations), potentially saving countless lives and preventing the rise of antimicrobial resistance. This approach may usher in a new era of emphasis on creating next-generation platforms for antimicrobial susceptibility testing that do not require blood cultures, thereby revolutionizing the present state of bacteremia diagnostics. The post Antimicrobial Susceptibility Test Turnaround Time Slashed b ..read more

Researchers have uncovered the genetic and energetic characteristics of leukemic stem cells that are responsible for acute myeloid leukemia (AML) and suggest that blocking a specific iron utilization process of these cells provides an avenue for new therapeutic strategies to fight this disease. The post New Therapeutic Target Found for Acute Myeloid Leukemia appeared first on Inside Precision Medicine ..read more

Fecal transplants from cancer patients who respond to checkpoint inhibitor immunotherapy can help boost treatment effect in non-responders. The post Fecal Microbiota Transplants Could Boost Cancer Immunotherapy Efficacy appeared first on Inside Precision Medicine ..read more

Preliminary research presented at the American Heart Association’s Basic Cardiovascular Sciences Scientific Sessions 2024 suggests that increasing ketone supply to the heart could significantly enhance energy production in cases of heart failure with preserved ejection fraction (HFpEF). The post New Research Shows Potential for Ketone Therapy in Heart Failure appeared first on Inside Precision Medicine ..read more

Pfizer saw positive results of its gene therapy for hemophilia A in a late stage study. The therapy, giroctocogene fitelparvovec, reduced patients’ bleeds for at least 15 months and was generally well tolerated. The post Pfizer Gene Therapy for Hemophilia A Nets Positive Results, but Leaves Questions appeared first on Inside Precision Medicine ..read more

An in-depth, single-cell map of gene expression in the brain of Alzheimer's disease patients shines new light on the disease pathology. The post Brain Atlas of Alzheimer’s Disease Could Help Design Better Treatments appeared first on Inside Precision Medicine ..read more

Microsoft and Paige have revealed the fruits of their collaborative labor in creating the most advanced AI-powered cancer pathology tool. A research article published in Nature Medicine demonstrates how their “foundational” model for computational biology, Virchow, has the unprecedented ability to model diverse patterns observed in pathology images. Named in honor of a pioneer of modern pathology, Rudolf Virchow, who proposed the first theory of cellular pathology, the model has best-in-class performance in biomarker prediction, cell identification, and pan-cancer detection. But perhaps the mo ..read more

A new study published in the Journal of the National Cancer Institute, has found that reducing disparities between Black and White people in colonoscopy follow-up completion rates and the quality of colonoscopy screenings would dramatically reduce colon cancer deaths. According to the study’s findings, efforts aimed at eliminating these disparities could lead to significant improvements in colorectal cancer (CRC) incidence, mortality rates, and life-years gained among Black individuals. Specifically, the study estimates that such efforts could reduce CRC incidence by up to 15%, mortality by 19 ..read more

A new study from the Mayo Clinic finds that current screening protocols fail to catch a significant number of individuals with genetic mutations linked to hereditary breast and ovarian cancer syndrome (HBOC) and Lynch syndrome, which increase the risk of developing certain cancers. Their findings, published in JCO Precision Oncology, finds that the rate of mutations is higher in underrepresented minorities than is currently assumed with current screening guidelines. The paper is the first to be published from the Tapestry study which has enrolled more than 100,000 patients seeking care at geog ..read more