Autoinjector are medical devices that enable the rapid and safe delivery of drugs through different administration routes. They are designed to offer patients a convenient and effective means of self-administering medications, particularly in emergency situations and chronic conditions (that require frequent injections). Further, various advancements, such as hidden or retractable needles (which mitigate the risk of accidental needle sticks) , user-friendly designs featuring ergonomic grips, and audible and visual indicators, have notably enhanced their usability, safety and dependability of a ..read more

In the dynamic landscape of the healthcare sector, the evolution of drug delivery systems plays a significant role in transforming the management of chronic diseases. Among the various innovations, self-injection devices (specifically autoinjector) have emerged as a promising solution. Autoinjector are self-injection devices that automatically insert the needle and deliver a particular amount of therapeutic into the skin (via spring driven mechanism). They are generally used in combination with primary containers, such as prefilled syringes and cartridges. Further, autoinjectors offer various ..read more

The evolution of the healthcare industry is being driven by advancements in technology and rising adoption of telemedicine & digital biomarker. With increasing digitization across the globe, the need for real-time data access, management and analysis of health data has gained remarkable importance. The growing use of wearable devices and mobile applications to monitor health parameters is leading to increased consumerization of healthcare. Unlike the past, when healthcare offerings were primarily organization oriented, digital tools have led to patients taking charge of their own health. F ..read more

Cell therapy refers to the introduction of active, healthy cells into a patient’s body in order to replace the damaged or previously compromised tissues. The cells used in the cell therapy can be from the patient’s own body (autologous) or from a donor (allogeneic). In allogeneic cell therapies, the cells are engineered (to elicit a desired therapeutic response) and amplified in-vitro. The modified cells can be preserved in a cell bank or administered to the patients. According to the Alliance for Regenerative Medicine, the number of clinical trials being conducted for allogeneic cell-based ca ..read more

Over the last decade, one of the major challenges faced by pharmaceutical companies across the globe is low drug solubility. In fact, it has been observed that around 40% of the pharmaceutical drugs approved by regulatory organizations exhibit poor bioavailability / solubility. Further, every year, poor bioavailability is one of the main causes of drug failure in obtaining approval authorization. As a result, the pharmaceutical industry is on the lookout for tools / techniques that can overcome this challenge. Amidst the ongoing initiatives to develop therapeutic interventions with improved bi ..read more

Rare kidney diseases are a group of conditions, with at least 150 different disorders falling into this category. Kidney disorders are known to have a serious impact on the general kidney function, often lowering its ability to filter out waste and fluids from the blood, maintaining blood pressure, hemoglobin levels and electrolyte balance. Kidney disorders can either be short-term (acute kidney injury) or lifelong (chronic). Despite their relatively low prevalence, rare kidney diseases, including Immunoglobulin A nephropathy, lupus nephritis, focal segmental glomerular sclerosis, membran ..read more

Biologics fill finish represent one of the fastest growing segments of the pharmaceutical industry. Over the years, these large molecules have demonstrated promising therapeutic outcomes in the treatment of myriad of chronic and challenging disorders, including autoimmune disorders, infectious diseases, genetic disorders, and oncological disorders. These complex entities, such as antibodies, antibody drug conjugates, cell therapies, gene therapies, and therapeutic proteins, are highly specific molecules that are designed to precisely target biomarkers associated with a particular disease pathw ..read more

The coronavirus outbreak and the drop in economy that we are facing today is unlike anything that most of us have seen in our lifetime. The pandemic has threatened the whole world to such an extent that life has come to a standstill. In fact, the initial stage of lockdown featured the fragile nature of pharmaceutical supply chain as a result of plant shutdowns and subsequent drug shortages. However, in order to deal with this situation, the medical agencies came up with the option of advanced technologies, such as continuous manufacturing technology. Specifically, in the pharmaceutical industr ..read more

Over the past few years, a number of antiviral drugs targeting a myriad of infectious diseases, including human immunodeficiency virus (HIV) infection, hepatitis, herpes simplex virus (HSV) infection, cytomegalovirus (CMV) infection, influenza, coronavirus infection (COVID-19) and others, have received approvals from various regulatory authorities, globally. However, it is important to note that, currently, the approved antiviral medications (around 80) are capable of targeting only 10 of the 220 known viruses that are responsible for causing multiple life threatening infectious diseases in hu ..read more

Messenger ribonucleic acid (mRNA) serves as a carrier of genetic instructions from DNA to the cell machinery for the production of proteins. mRNA technology plays a significant role in the development of therapeutic interventions, exemplified by the incredible success of COVID-19 vaccines (namely COMIRNATY and Spikevax). It holds promise in treating various autoimmune disorders, degenerative disorders, genetic disorders, metabolic disorders, infectious diseases and oncological disorders. Further, mRNA therapeutics offer advantages (over traditional small molecules) such as simpler design, shor ..read more