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Resources for calculating sample size for clinical trials. Insights from our sample size experts.
Statsols
1M ago
Why Calculate Sample Size?
A good statistical study is one that is well designed and leads to valid conclusions. This however, is not always the case, even in published studies. In Cohen’s (1962) seminal power analysis of the journal of Abnormal and Social Psychology he concluded that over half of the published studies were insufficiently powered to result in statistical significance for the main hypothesis ..read more
Statsols
1M ago
Everything to Know About Sample Size Determination A step-by-step interactive guide including common pitfalls ..read more
Statsols
1M ago
Free nQuery GSD training session
Below is a recording of a training session that focuses on one ofour most requested topics - Group Sequential Designs.
When conducting these types of trials there are a wide variety of methods available and theoretical decisions to be made.
This recent nQuery GSD training session gets to the core of what we think, can help you the most, in the shortest timeframe. We cover:
Ian DeMets
Wang-Tsiatis
Haybittle Peto
How to maximize the new Group Sequential Design features in nQuery ..read more
Statsols
1M ago
About the webinar
Sequential designs, where trials can stop early based on interim results, are the most widely used type of adaptive design in clinical trials.
Group sequential design is one of the most widely used approaches to designing and analysing sequential trials. However, this class of design has a wide variety of unique theoretical and practical choices that require consideration.
In the second of this two-part webinar series, we discuss the different types of group sequential design and the best approaches for maximising the value of this trial design type ..read more
Statsols
1M ago
About the webinar
2020/21 led to significant clinical trial innovation in clinical trials in response to the Covid-19 pandemic with 2022 providing key insights, projects and lessons in the wider clinical trials space.
2023 will see these lessons merge with long-term trends and the lessons from important pilot programs to see wider use of innovative designs and methods.
In this webinar, we look at three linked areas where these lessons will be applied and significant milestones that we expect will be reached in 2023 ..read more
Statsols
1M ago
About the webinar
Randomization of subjects between treatment groups in a clinical trial is an essential statistical element that allows one to claim that a study will be unbiased.
In this webinar, we look at the benefits that randomization provides and examine the properties of three well known algorithms for generating randomization lists: block randomizationcomplete randomization and Efron’s biased coin randomization.
Further below, you will find the webinar recording, slides and worked examples ..read more
Statsols
1M ago
About the webinar
Complex endpoints are an increasingly common challenge for clinical trial design. We evaluate three complex endpoints, the appropriate models for such endpoints and the sample size determination approaches available for these models. In this webinar we look at sample size for the proportional odds model for ordinal data, the Win Ratio statistic for composite endpoints and the MaxCombo test for complex survival analysis ..read more
Statsols
1M ago
Milestone Prediction and Sample Size for Prediction Models
Sample size determination is a key part of trial planning but is typically focussed on statistical success criteria such as Type I error and power.
Prediction calculations instead focus on more practical considerations such as accuracy or timing. In this webinar, we explore where these two areas intersect and how each can help us improve our understanding of the other ..read more
Statsols
1M ago
Sample Size for Pilot Studies Maximising the value of pilot data
Explore The Data
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Download and explore the data yourself. Data files include:
T-Test Sample Size Calculation - Example 1 and 2. nqt
Pilot Sample Size (Whitehead Overall Program) - Example 1 .nqt
Pilot Sample Size (UCL Manual SD Calculation) - Example 1 .nqt
Mean Difference Confidence Interval - Example 1 .nqt
Internal Pilot Two Means - Example 2 .nqt
Internal Pilot Two Proportions - Example 3 .nqt
Case-Control Phase IV Study - Example 3 .nqt
Internal P ..read more
Statsols
3M ago
Powering Phase IV Clinical Trials Design Considerations for Post-Marketing Surveillance Trials
Explore The Data
Get The Deck
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Download and explore the data yourself. Data files include:
One Arm Cohort Phase IV Study - Example 1. nqt
One Arm Cohort Phase IV Study - Example 2 .nqt
Two Arm Cohort Phase IV Study - Example 2b .nqt
Case-Control Phase IV Study - Example 3 .nqt
Powering Phase IV Clinical Trials Design Considerations for Post-Marketing Surveillance Trials
Clinical trials are primarily involved in establishing the safety ..read more