5 Benefits of CBD Oil
The CBD Medical Post
by Frazer Kearl
4y ago
Can Reduce Anxiety and Depression Significant limitations with the currently available antidepressant treatment strategies have inspired research on finding new and more efficient drugs to treat depression. Recent evidence suggests that CBD promotes both a rapid and sustained antidepressant effect in animal models. A recently published study assessed 1483 individuals who have used CBD for treating several medical conditions. Of those, around 400 patients reported the use of CBD to achieve mood-improving effects, with 250 patients reporting CBD worked “very well by itself”. Click here to read ..read more
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CBD vs. THC What's The Difference?
The CBD Medical Post
by Frazer Kearl
4y ago
CBD is typically the second-most abundant cannabinoid in cannabis behind THC. Most of our readers know that THC is psychoactive and CBD is not, but why is that the case? If you have a keen eye you may be able to see that the above molecules are very similar (although oriented differently). So if they look so similar, why does one make us ‘high’ and the other not. Well, THC exerts its most prominent effects via its actions on two types of cannabinoid receptors, the CB1 receptor and the CB2 receptor, both of which are G prot ..read more
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Cannabidiol (CBD) for Chronic Pain
The CBD Medical Post
by Frazer Kearl
4y ago
Cannabidiol has substantial anti-inflammatory and immunomodulatory effects. This study published in 2007 investigated its therapeutic potential on neuropathic and inflammatory pain in rats. In both models, daily oral treatment with cannabidiol (2.5–20 mg/kg to neuropathic and 20 mg/kg to adjuvant-injected rats) from day 7 to day 14 after the injury, reduced hyperalgesia (pain sensitivity) to thermal and mechanical stimuli. In the neuropathic animals, the anti-hyperalgesic effect of cannabidiol (20 mg/kg) was prevented by the vanilloid antagonist capsazepine (10 mg/kg, i.p.), but not by cannabi ..read more
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Cannabidiol (CBD) for Parkinson's Disease
The CBD Medical Post
by Frazer Kearl
4y ago
Many of our readers may have already seen the video below where Larry tries CBD oil for the first time. With a few drops of cannabis oil under his tongue, Larry's severe dyskinesia (uncontrolled movements), loss of voice, and tremors are calmed within in minutes. Recent literature has shown that anecdotal evidence has supported the notion that CBD can exert a beneficial role, alone or in combination with THC, in different neurodegenerative disease, such as Parkinson’s disease and Huntington's disease, two chronic disorders provoked by degenerative processes implicating specific nuclei of the ..read more
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Cannabidiol (CBD) for Epilepsy
The CBD Medical Post
by Frazer Kearl
4y ago
Epilepsy is a common neurologic disorder; it is estimated that ∼50 million people are affected worldwide. About one third of those patients are drug resistant, defined as failure to stop all seizures despite adequate trials of at least 2 appropriate medications. There has been an enormous interest in developing antiepileptic drugs with novel mechanisms of action. This review discusses the evidence supporting the anticonvulsant properties of cannabis in humans, focusing on cannabidiol. This review explores the early and somewhat anecdotal evidence that was recently replaced by high-quality data ..read more
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Cannabidiol (CBD) for Allergic Asthma
The CBD Medical Post
by Frazer Kearl
4y ago
Asthma is characterized by chronic lung inflammation and airway hyperresponsiveness. Asthma remains a major public health problem and, at present, there are no effective interventions capable of reversing airway remodelling. Cannabidiol (CBD) is known to exert immunomodulatory effects through the activation of cannabinoid-1 and − 2 (CB1 and CB2) receptors located in the central nervous system and immune cells, respectively. However, as the role of CBD on airway remodelling and the mechanisms of CB1 and CB2 aren’t fully elucidated, a January 2019 study was designed to evaluate the effects of ca ..read more
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Cannabidiol (CBD) for Aggression
The CBD Medical Post
by Frazer Kearl
4y ago
Some of the latest research has lead to the suggestion that CBD may help to reduce aggressive behavior. So far, this has only been tested in mice but it makes for some interesting reading and this article includes a summary of a paper published in Progress in Neuro-Psychopharmacology and Biological Psychiatry. Long-term single housing increases aggressive behavior in mice, a condition named isolation-induced aggression or territorial aggression, which can be attenuated by anxiolytic, antidepressant, and antipsychotic drugs ..read more
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Cannabidiol (CBD) for Anxiety
The CBD Medical Post
by Frazer Kearl
4y ago
According to Lee et al (2017), there is accumulating preclinical evidence investigating the effects of CBD on fear memory processing indicating that it reduces learned fear in paradigms that are relevant to phobias. This may be associated with attenuation of the acute autonomic responses associated to stress (Fogaca et al., 2014; Fusar-Poli et al., 2009), whilst the extinction of fear memories will occur through indirect activation of CB1 receptors (Bitencourt et al., 2008; Lee et al., 2017). Other mechanisms associated with the anxiolytic properties of CBD may also include CBD-related modific ..read more
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Cannabidiol (CBD) for Cognition
The CBD Medical Post
by Frazer Kearl
4y ago
A September 2019 review article in the NeuroToxicology journal found that CBD appeared to have beneficial effects on cognition compared to THC both in healthy controls and in cannabis users (Colizzi and Bhattacharyya, 2017; Englund et al., 2013; Morgan et al., 2010b, 2012; Solowij et al., 2018). In a study involving a healthy population, a placebo CBD pre-treated group compared to a placebo pre-treated group resulted in both episodic and verbal memory tasks better performances after intravenous THC administration (Englund et al., 2013; Colizzi and Bhattacharyya, 2017). Some 134 users were divi ..read more
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Cannabidiol (CBD) for Depression
The CBD Medical Post
by Frazer Kearl
4y ago
Significant limitations with the currently available antidepressant treatment strategies have inspired research on finding new and more efficient drugs to treat depression. Recent evidence suggests that CBD promotes both a rapid and a sustained antidepressant effect in animal models. This July 2019 review of the most recent articles on CBD and its antidepressant effect suggests that CBD has a complex pharmacology, with the ability to interact with multiple neurotransmitter systems involved in depression. According to the sa ..read more
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