Activating the hidden pharmaceutical potential of bacteria
ScienceDaily » CRISPR Gene Editing News
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2M ago
Microorganisms produce a wide variety of natural products that can be used as active ingredients to treat diseases such as infections or cancer. The blueprints for these molecules can be found in the microbes' genes, but often remain inactive under laboratory conditions. A team of researchers has now developed a groundbreaking genetic method that leverages a natural bacterial mechanism for the transfer of genetic material and uses it for the production of new active ingredients ..read more
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CRISPR-Cas technology: Balancing efficiency and safety
ScienceDaily » CRISPR Gene Editing News
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2M ago
Researchers have uncovered a serious side effect of using the CRISPR-Cas gene scissors. A molecule designed to make the process more efficient destroys parts of the genome ..read more
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'We're not all that different': Study IDs bacterial weapons that could be harnessed to treat human disease
ScienceDaily » CRISPR Gene Editing News
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2M ago
When it comes to fighting off invaders, bacteria operate in a remarkably similar way to human cells, possessing the same core machinery required to switch immune pathways on and off, according to new research ..read more
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New gene drive reverses insecticide resistance in pests... then disappears
ScienceDaily » CRISPR Gene Editing News
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2M ago
Geneticists have developed a gene drive-based solution to the widespread problem of insecticide resistance. In an effort to protect valuable crops, the researchers created an 'e-Drive' that reverses insecticide resistance and then disappears from the insect population ..read more
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Labeling cell particles with barcodes
ScienceDaily » CRISPR Gene Editing News
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2M ago
Cell-to-cell communication through nanosized particles, working as messengers and carriers, can now be analyzed in a whole new way, thanks to a new method involving CRISPR gene-editing technology. The particles, known as small extracellular vesicles (sEVs), play an important role in the spread of disease and as potential drug carriers. The newly developed system, named CIBER, enables thousands of genes to be studied at once, by labeling sEVs with a kind of RNA 'barcode.' With this, researchers hope to find what factors are involved in sEV release from host cells. This will help advance our und ..read more
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Using CRISPR to decipher whether gene variants lead to cancer
ScienceDaily » CRISPR Gene Editing News
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3M ago
Researchers have combined two gene editing methods. This enables them to quickly investigate the significance of many genetic mutations involved in the development and treatment of cancer ..read more
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Finding function for noncoding RNAs using a new kind of CRISPR
ScienceDaily » CRISPR Gene Editing News
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3M ago
Genes contain instructions for making proteins, and a central dogma of biology is that this information flows from DNA to RNA to proteins. But only two percent of the human genome actually encodes proteins; the function of the remaining 98 percent remains largely unknown. One pressing problem in human genetics is to understand what these regions of the genome do -- if anything at all. Historically, some have even referred to these regions as 'junk.' Now, a new study finds that some noncoding RNAs are not, in fact, junk -- they are functional and play an important role in our cells, including i ..read more
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Use of 'genetic scissors' carries risks
ScienceDaily » CRISPR Gene Editing News
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3M ago
The CRISPR tool is capable of repairing the genetic defect responsible for the immune disease chronic granulomatous disease. However, researchers have now shown that there is a risk of inadvertently introducing other defects ..read more
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Researchers discover underlying mechanisms that make CRISPR an effective gene editing tool
ScienceDaily » CRISPR Gene Editing News
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3M ago
Using state-of-the-art technology, researchers have identified several specific steps needed for CRISPR to become active and perform its gene editing function. These preclinical findings could lead to improved designs for CRISPR-based gene editing ..read more
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CRISPR insight: How to fine-tune the Cas protein's grip on DNA
ScienceDaily » CRISPR Gene Editing News
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3M ago
At the heart of every CRISPR reaction, whether naturally occurring in bacteria or harnessed by CRIPSR-Cas gene editing technology, is a strong molecular bond of a Cas protein via a guide RNA to its target site on DNA. It's like a nanoscale ski binding ..read more
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