S5E04: Engineering Therapeutic Antibodies
Two Scientists Walk Into a Bar
by Genentech
2w ago
Antibodies are proteins produced by our immune system that neutralize or help destroy abnormal cells and foreign agents, like bacteria and viruses. However, their utility extends beyond our bodies’ defense system. Antibodies can also be engineered in the lab to be used as therapies. Today, over 170 antibodies have been approved as medicines to treat a wide range of diseases including cancers, autoimmune diseases, infectious diseases and more. In this episode, co-host Maria Wilson chats with guests Yan Wu, VP and Senior Fellow, Antibody Engineering, and Paul Carter, Genentech Fellow, Antibody E ..read more
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S5E03: No Delivery, No Drug
Two Scientists Walk Into a Bar
by Genentech
1M ago
Many health conditions require medicines that can be delivered to specific parts of the body. For instance, someone with asthma requires medication that targets the lungs, while someone with a neurodegenerative disease needs therapeutics that can penetrate the blood-brain barrier. But how do scientists create medicines that not only reach their intended targets but also produce the desired pharmacological effect while minimizing side effects and ensuring convenience for the patient? In this episode, co-host Danielle Mandikian chats with Karthik Nagapudi, Executive Director of Pharmaceutics, to ..read more
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S5E02: Seeing Clearly: The Past, Present and Future of Eye Treatment
Two Scientists Walk Into a Bar
by Genentech
2M ago
Imagine the eyes as cameras, where the cornea acts as the lens and the retina as the film. As with a camera, if something goes wrong in the eye, it needs to be fixed to address the specific problem and restore function. While some visual impairments can be corrected with glasses or surgery, some conditions require medicines – like those that slow or stop blood vessel growth in the eye. In this episode, co-host Danielle Mandikian joins guests Chris Brittain, Vice President and Global Head of Ophthalmology Product Development, and Dolly Chang, Group Medical Director, gRED Early Clinical Developm ..read more
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S5E01: Merging Minds and Machines: The Future of Drug Discovery
Two Scientists Walk Into a Bar
by Genentech
3M ago
Computational approaches have revolutionized how we interpret data. With the advent of genomic sequencing, scientists can derive significant conclusions from sequence data. For example, through transcriptomics – the study of genes and their expression in different cells – researchers have made groundbreaking discoveries in fields like developmental and disease biology. More recently, computational approaches have expanded with the introduction of generative artificial intelligence (AI) and its ability to generate new insights from massive datasets, diverse in scope, which can be validated in t ..read more
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Season Five Teaser
Two Scientists Walk Into a Bar
by Genentech
5M ago
Join Danielle Mandikian and Maria Wilson as they kick off season five of Two Scientists Walk Into a Bar. Hear about their recent lab adventures and enjoy a sneak preview of exciting topics for our new season. From demystifying the impact of AI and machine learning in drug development to exploring diverse modalities for treating diseases, we've got an exciting lineup in store. Subscribe today so you don’t miss an episode! Read the full text transcript at: www.gene.com/stories/season-five-teaser ..read more
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S4E08: Learning from Vaccines: Training our Immune System to Fight Cancer
Two Scientists Walk Into a Bar
by Genentech
1y ago
When we consider how a vaccine works, we typically think about vaccines that prevent infectious disease like flu or measles. But another type, known as therapeutic vaccines, may be able to treat diseases even after they’ve taken hold in the body – including cancer and viral infections. Similar to preventative vaccines, these therapeutic cancer vaccines work by promoting an immune response. Cancer vaccines are an emerging approach that have the potential to train the immune system to better seek out and destroy cancer cells. Co-host Danielle Mandikian sits down with Lélia Delamarre, Director an ..read more
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S4E07: Representation Matters: Inclusivity in Clinical Trials
Two Scientists Walk Into a Bar
by Genentech
2y ago
Because disease outcomes and responses to treatment can vary across populations, clinical research must include patients who are racially, ethnically and gender representative of those who experience health conditions. Scientists are pioneering new ways of achieving inclusive and diverse clinical trials to generate clear results and reveal insights when evaluating new medicines. Co-host Maria Wilson sits down with Nicole Richie, Global Head of Health Equity and Population Science, and Jenn Pangilinan, Vice President, Genentech Research and Early Development (gRED) Clinical Operations, to discu ..read more
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S4E06: It's Personal: Inclusive Research and Precision Medicine
Two Scientists Walk Into a Bar
by Genentech
2y ago
Achieving the first complete sequence of a human genome via the Human Genome Project represents an incredible feat – but it’s just the tip of the iceberg when it comes to unlocking the power of genomics for drug discovery and development. As the scientific community builds on our understanding of genomics, one of the most critical questions becomes, how can we thoughtfully collect and use genetic data to better understand and support the health of all communities, especially those who have been excluded from research in the past? Co-host Maria Wilson sits down with Mark McCarthy, Principal Fel ..read more
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S4E05: Antibiotic Resistance: A Call to Arms
Two Scientists Walk Into a Bar
by Genentech
2y ago
Bacteria – and their constant ability to rapidly evolve and adapt – represent a scientific challenge that’s equal parts fascinating and disconcerting. The incredible innovations of the past century have not only prevented and treated infections that would otherwise be lethal, but also helped safeguard patients through critical surgeries and other treatments. However, challenges abound for the scientific community when it comes to discovery and development of new antibiotics. Chief among these is antibiotic resistance, with more than 2.8 million antibiotic-resistant infections every year leadin ..read more
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S4E04: The Where and When of Alzheimer’s Disease
Two Scientists Walk Into a Bar
by Genentech
2y ago
Understanding what happens in the brain is notoriously difficult, but scientists have made progress in the past few decades. For Alzheimer’s disease, scientists have expanded their knowledge of where and when certain proteins, cells and biologic processes can contribute to memory loss and the progression of the disease. Co-host Maria Wilson speaks to Jasi Atwal, Senior Scientist, Neuroscience, and Edmond Teng, Senior Medical Director, to discuss the diverse theories and research approaches to Alzheimer’s disease and how they are informing the development of potential new treatments. Read the f ..read more
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