Transcription Profile Analysis of Vastus Lateralis Muscle from Patients with Chronic Fatigue Syndrome T. Pietrangelo; R. Mancinelli; L. Toniolo; G. Montanari; J. Vecchiet; G. Fanò; S. Fulle Chronic fatigue syndrome (CFS) is a disabling condition characterized by unexplained chronic fatigue that impairs normal activities. Many body systems are affected and etiology has not yet been identified. In addition to immunological and psychological aspects, skeletal muscle symptoms are... Transcription Profile Analysis of Vastus Lateralis Muscle from Patients with Chronic Fatigue Syndrome, 2009, Pietr ..read more

In Vivo Tissue Distribution of Polystyrene or Mixed Polymer Microspheres and Metabolomic Analysis after Oral Exposure in Mice, 2024, Marcus M. Garcia, et al. https://ehp.niehs.nih.gov/doi/10.1289/EHP13435 https://doi.org/10.1289/EHP13435 PDF (auto-download) Abstract Background: Global plastic use has consistently... In Vivo Tissue Distribution of Polystyrene or Mixed Polymer Microspheres and Metabolomic Analysis after Oral Exposure in Mice, 2024, Marcus M. Garcia ..read more

For many years, and especially when I have PEM/ crash, I've found myself lying in bed, and breathing seems to take too much energy. A better way of describing it would be that if I don't wait from 5-10 seconds after a slow exhale, I get a buildup of tightness in my chest and can actually feel dizzy. I didn't think about this much until I started doing meditative breathing to try to help insomnia, and the recommendation for one method was 4 count breath in, 6 count breath hold, 8 count... Anyone experience bradypnea with ME/CFS ..read more

This annoys me. The person being interviewed spends a lot of it deflecting blame onto others : https://endocrinenews.endocrine.org/solving-the-hypothyroidism-puzzle-qa-antonio-bianco-md-phd/ I'm glad that at least some doctors are changing their minds about hypothyroidism treatment rather than blaming the patient, but why did it have to take so long ..read more

Physiological pain serves as a warning of exposure to danger and prompts us to withdraw from noxious stimuli to prevent tissue damage. Pain can also alert us of an infection or organ dysfunction and aids in locating such malfunction. However, there are instances where pain is purely pathological, such as unresolved pain following an inflammation or injury to the nervous system, and this can be debilitating and persistent. We now appreciate that immune cells are integral to both... Immune drivers of physiological and pathological pain, 2024, Aakanksha Jain et al ..read more

"Chloe Beak lives with chronic, debilitating migraines, which leave her unable to attend school for days at a time. But instead of receiving support from her school, her parents have been fined by the local authority for her truancy. The family’s current fix is to send their daughter in with a migraine until she gets sent home, meaning her absences are registered as authorised. If they do not, the school will consider her a truant as it believes she has emotionally based school avoidance.... UK: Guardian: ‘She wants to go to school’: parents of unwell child fear truancy prosecution ..read more

OCALA, Fla., April 15, 2024 (GLOBE NEWSWIRE) -- AIM ImmunoTech Inc. (NYSE American: AIM) (“AIM”) today announced that Charles Lapp, MD, is joining the company to help lead its efforts to develop Ampligen (rintatolimod) as a potential treatment for Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and Long COVID.... AIM ImmunoTech Announces Charles Lapp, MD, as a Consulting Medical Officer for its ME/CFS and Long COVID Programs ..read more

What is quality in long covid care? Lessons from a national quality improvement collaborative and multi-site ethnography Greenhalgh, Trisha; Darbyshire, Julie L.; Lee, Cassie; Ladds, Emma; Ceolta-Smith, Jenny Long covid (post covid-19 condition) is a complex condition with diverse manifestations, uncertain prognosis and wide variation in current approaches to management. There have been calls for formal quality standards to reduce a so-called “postcode lottery” of care. The... What is quality in long covid care? Lessons from a national quality improvement collaborative and multi-site ethnogr ..read more

Pain and the biochemistry of fibromyalgia: patterns of peripheral cytokines and chemokines contribute to the differentiation between fibromyalgia and controls and are associated with pain, fat infiltration and content Gerdle, Björn; Dahlqvist Leinhard, Olof; Lund, Eva; Lundberg, Peter; Forsgren, Mikael Fredrik; Ghafouri, Bijar OBJECTIVES This explorative study analyses interrelationships between peripheral compounds in saliva, plasma, and muscles together with body composition... Pain and the biochemistry of fibromyalgia: patterns of peripheral cytokines and chemokines [...], 2024, Gerdle et ..read more

https://www.sciencedirect.com/science/article/abs/pii/S0944711324002952 Phytomedicine Available online 13 April 2024, 155636 Original Article Sijunzi decoction, a classical Chinese herbal formula, improves fatigue symptoms with changes in gut microbiota in chronic fatigue syndrome: A randomized, double-blind, placebo-controlled, multi-center... Sijunzi decoction...improves fatigue symptoms with changes in gut microbiota in CFS: A randomized, double-blind, placebo-controlled etc., 2024, Dai ..read more