Feline pituitary adenomas
Winn Feline Foundation
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3y ago
Miller MA, Piotrowski SL, Donovan TA, Scott-Moncrieff JC, Owen TJ, McCue JP, DuSold DM, Ramos-Vara JA, Weng HY, Chen AV, Martin LG, Bruyette DS. Feline Pituitary Adenomas: Correlation of Histologic and Immunohistochemical Characteristics With Clinical Findings and Case Outcome. Vet Pathol. 2020 Dec 7. Acromegaly is an increasingly recognized disorder of cats caused by a secretory adenoma in the pituitary gland (somatotroph) which produces an excess of growth hormone. Traditionally this condition leads to diabetes mellitus, enlarged head and paws, cardiac disease, and bone alterations. Ho ..read more
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Urine concentrations of amoxicillin and clavulanate in cats
Winn Feline Foundation
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3y ago
KuKanich K, Woodruff K, Bieberly Z, Papich MG, KuKanich B. Evaluation of urine concentrations of amoxicillin and clavulanate in cats. J Vet Intern Med. 2020 Dec 6. (Winn funded study) Urinary tract infections are commonly encountered in domestic animals, and among the most common causes is E coli. Guidelines for the treatment of UTIs recommended culture and susceptibility to determine the antibiotic with the lowest global priority that is able to effectively treat the infection. Amoxicillin‐clavulanate is among the most commonly used antibiotics in the treatment of urinary tract ..read more
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Prognostic utility of a test in cats with malignant mammary tumors
Winn Feline Foundation
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3y ago
Naito E, Yuki M, Hirano T, Kainuma D, Aoyama R. Prognostic utility of preoperative neutrophil–lymphocyte ratio in cats with malignant mammary tumors. Res Vet Sci. October 2020.  Malignant mammary tumors are commonly encountered in intact female cats or those who underwent multiple heat cycles prior to spaying. Therapy of mammary cancer is based on removal of the tumor in combination with radical (and preferably bilateral) mastectomy to remove all mammary tissue, potentially in combination with chemotherapy. Despite this. Metastatic disease and tumor related death is common. Several ..read more
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Evaluating a treatment for feline thromboembolism
Winn Feline Foundation
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3y ago
 W19-014   Targeted intra-arterial administration of tissue plasminogen activator as a treatment for feline distal aortic thromboembolism. (Winn funded interim grant progress report summary) Principal Investigators: Dr. Sigal Klainbart, Dr. Joshua Milgram; Koret School of Veterinary Medicine, Israel   Aortic thromboembolism (ATE) is a life-threatening condition in cats in which a thrombus formed in the heart enters the aorta and blocks the blood flow to the hind limbs, leaving the cat often in pain and unable to walk. Currently, there is no definitive treatment for this co ..read more
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Precision medicine genomics for cats continuation
Winn Feline Foundation
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3y ago
 MT19-001    Precision medicine genomics for cats (continued)  (Winn funded interim grant progress report summary) Principal Investigator: Leslie Lyons PhD; University of Missouri-Columbia The overall focus of our research is to discover DNA variants causing traits and diseases in domestic cats and their breeds.  The overall goal is to eradicate genetic diseases from cat populations using genetic testing that will inform owners and breeders of the status of their animals so they can use proper breeding practices to eliminate diseases or produce desired trait ..read more
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Metastatic feline mammary cancer
Winn Feline Foundation
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3y ago
Petrucci G, Henriques J, Gregório H, et al. Metastatic feline mammary cancer: prognostic factors, outcome and comparison of different treatment modalities – a retrospective multicentre study. J Feline Med Surg. October 2020. Mammary cancer in cats is a common, highly aggressive tumor that requires aggressive therapy to control. It is most common in intact cats or those who experienced heat cycles prior to spaying. Unlike mammary cancer in dogs, over 90% of feline mammary cancer is malignant. The disease is often metastatic at the time of diagnosis, though metastases may be microscopic. T ..read more
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Analyzing the effects of antibiotics on intestinal microbiota of kittens
Winn Feline Foundation
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3y ago
 MT18-003   Metagenomic and metabolomic analysis of the short-term and long-term effects of antibiotic therapy on the intestinal microbiota in growing kittens and their relation to the overall health status of these kittens. (Winn funded interim grant progress report) Principal Investigators: JS Suchodolski, JM Steiner, EM Stavroulaki; Texas A&M University; PG Xenoulis; Thessaly University A total of seventy kittens were enrolled during the first six months of this study. Based on the research proposal, a total of forty-five kittens are required for the study. However, add ..read more
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Are polymorphisms a risk factor in FIP development?
Winn Feline Foundation
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3y ago
W18-010  Are interferon-gamma polymorphisms a risk factor in FIP development – a large cohort study. (Final grant project summary) Principal Investigators: Dr. Emi Barker, Dr. Christopher Helps; University of Bristol, UK Feline infectious peritonitis (FIP) is a common infectious cause of death in cats. Increased incidence of FIP within particular breeds, or lines of breeds, is suggestive of inherited genetic risk factors. For other genetic diseases, out-crossing with non-pedigree cats has been suggested to increase genetic diversity and reduce risk of various genetic diseases in those br ..read more
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Safety and tolerability of pimobendan in cats with cardiomyopathy
Winn Feline Foundation
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3y ago
Ward JL, Kussin EZ, Tropf MA, Tou SP, DeFrancesco TC, Keene BW. Retrospective evaluation of the safety and tolerability of pimobendan in cats with obstructive vs nonobstructive cardiomyopathy. J Vet Intern Med. 2020. Hypertrophic cardiomyopathy (HCM) is the most common cause of heart disease in cats, and is a disease of diastolic dysfunction. Pimobendan is a positive inotrope that increases cardiac contractility, and is used as a mainstay of therapy in dogs with mitral valve disease or dilated cardiomyopathy (both conditions of systolic dysfunction). As such, pimobendan is not routinely ..read more
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Exploring a new treatment method for continuous pneumothorax in a cat
Winn Feline Foundation
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3y ago
Bersenas AM, Hoddinott KL. Allogenic blood patch pleurodesis for continuous pneumothorax in three cats. J Feline Med Surg Open Reports. 2020;6(2).  Pneumothorax refers to the presence of air between the lungs and the wall of the chest. When present, it prevents full expansion of the lungs and may result in respiratory distress of even death. A continuous pneumothorax occurs when there is a constant leak of air into the chest. Air may enter the chest either from the outside (through a defect of the chest wall) or internally (through a defect in the lungs). Pneumothorax may occur as a ..read more
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