Food allergy (FA) is one of the most common chronic conditions in the pediatric age with an increasing prevalence under the pressure of environmental factors in predisposed individuals. It has been hypothesized that the increased consumption of ultra-processed foods, containing high levels of dietary advanced glycation end-products (AGEs), could facilitate the occurrence of food allergy ..read more

In the past two decades, a significant number of studies have been published describing the molecular and clinical aspects of Immune dysregulation Polyendocrinopathy Enteropathy X-linked Syndrome (IPEX). These studies have refined our knowledge of this rare yet prototypic genetic autoimmune disease, advancing the diagnosis, broadening the clinical spectrum, and improving our understanding of the underlying immunological mechanisms. Despite these advances, Forkhead box P3 (FOXP3) mutations have devastating consequences, and treating patients with IPEX remains a challenge even with safer strateg ..read more

Capsule SummaryTRPV1-positive nerves play a pivotal role in the restoration of barrier function following epidermal injury. The neuropeptide, somatostatin, released from TRPV1-positive nerves confers protection against IL-6-induced downregulation of keratinocyte differentiation ..read more

GenIA holistically catalogs the clinical, phenotypic, mechanistic, and genetic complexities of monogenic immune disease. Our pilot study demonstrates how it can be used for versatile applications, from answering diagnostic and management questions to generating novel hypotheses ..read more

Capsule Summary: In this cohort study, presence of NSAID ADR labeling was associated with increased inpatient opioid utilization in the immediate postpartum period, and higher rates of opioid prescribing at hospital discharge following delivery ..read more

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CAPSULE SUMMARYGrass allergen (Phl p 5) levels are more consistently associated with allergic respiratory symptoms than grass pollen counts. Measuring airborne allergen levels may improve risk prediction and help patients better control their symptoms ..read more

Racial disparities in atopic disease (atopic dermatitis (AD), asthma, and allergies) prevalence are well documented. Despite strong associations between race and socioeconomic deprivation in the United States (US), and socioeconomic status (SES) and atopic diseases, the extent to which socioeconomic status (SES) explains these disparities is not fully understood ..read more