Journal of Allergy and Clinical Immunology on Feedspot

T-cell receptor sequencing in interrogating antigen-specific T-cell responses to foreign and self-antigens

Journal of Allergy and Clinical Immunology

by Alexandra M. Johansson, William W. Kwok

8h ago

Visit website

Inter-Alpha-Trypsin Inhibitor Heavy Chain 4 (ITIH4) as a Compensatory Protease Inhibitor in Hereditary Angioedema (HAE)

Journal of Allergy and Clinical Immunology

by Anne Troldborg, Zsofia Godnic-Polai, László Cervenak, Annette G. Hansen, Henriette Farkas, Steffen Thiel

8h ago

Hereditary angioedema (HAE) is a genetic disorder that manifests as recurrent angioedema attacks, most frequently due to absent or reduced C1 inhibitor (C1-INH) activity. C1-INH is a crucial regulator of enzymatic cascades in the complement, fibrinolytic, and contact systems. Inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) is an abundant plasma protease inhibitor that can inhibit enzymes in the proteolytic pathways associated with HAE. Nothing is known about its role in HAE ..read more

Visit website

Should ‘primary immune disorder’ replace ‘inborn error of immunity’? Names matter but there’s room for both

Journal of Allergy and Clinical Immunology

by Stuart E. Turvey, Catherine M. Biggs, Elliot L. James, Kyla J. Hildebrand

2d ago

Visit website

Population descriptors in asthma and allergy research: Time to re-group

Journal of Allergy and Clinical Immunology

by Carole Ober, Christine L.M. Joseph, John Novembre

5d ago

Visit website

β1 integrin-mediated mast cell immune-surveillance of blood vessel content

Journal of Allergy and Clinical Immunology

by Kristina Link, Lina Muhandes, Anastasia Polikarpova, Tim Lämmermann, Michael Sixt, Reinhard Fässler, Axel Roers

1w ago

Immunoglobulin E, IgE)-mediated degranulation of mast cells, MCs) provides rapid protection against environmental hazards, including animal venoms. A fraction of tissue-resident MCs intimately associates with blood vessels. These perivascular MCs were reported to extend projections into the vessel lumen and to be the first MCs to acquire intravenously injected IgE, suggesting that IgE loading of MCs depends on their vascular association ..read more

Visit website

Preparing Patients for Oral Immunotherapy (PPOINT): International Delphi consensus for procedural preparation and consent

Journal of Allergy and Clinical Immunology

by Douglas P. Mack, Timothy E. Dribin, Paul J. Turner, Richard L. Wasserman, Mariam A. Hanna, Marcus Shaker, Mimi L.K. Tang, Pablo Rodríguez del Río, Brad Sobolewski, Elissa M. Abrams, Aikaterini Anagnostou, Stefania Arasi, Sakina Bajowala, Philippe Bégin, Scott B. Cameron, Edmond S. Chan, Sharon Chinthrajah, Andrew T. Clark, Paul Detjen, George du Toit, Motohiro Ebisawa, Arnon Elizur, Jeffrey M. Factor, Justin Greiwe, Jonathan O’B Hourihane, Sarah W. Hughes, Douglas H. Jones, Antonella Muraro, Anna Nowak-Wegrzyn, Nandinee B. Patel, Amy M. Scurlock, Atul N. Shah, Sayantani B. Sindher, Stephen Tilles, Brian P. Vickery, Julie Wang, Hugh H. Windom, Matthew Greenhawt

2w ago

Despite the promise of oral immunotherapy (OIT) to treat food allergies, this procedure is associated with potential risk. There is no current agreement about what elements should be included in the preparatory or consent process ..read more

Visit website

A Practical Guide for Implementing Omalizumab Therapy for Food Allergy

Journal of Allergy and Clinical Immunology

by Thomas B. Casale, Alessandro Fiocchi, Matthew Greenhawt

2w ago

The recent approval of omalizumab for the treatment of IgE-mediated food allergy is an important step forward for the millions of food allergy patients in the US. Through the depletion of circulating IgE and the subsequent reduction of FCεR1 on key effector cells, patients increase their tolerance to food allergens. However, omalizumab does not permit patients to eat foods that they are allergic to with impunity. Rather, it protects them from most accidental exposures. In addition, omalizumab does not cure food allergy and has not demonstrated true immunomodulation ..read more

Visit website

Identification of pyruvic and maleic acid as potential markers for disease activity and prognosis in chronic urticaria

Journal of Allergy and Clinical Immunology

by Xingxing Jian, Guixue Hou, Liqiao Li, Zhuo Diao, Yingfang Wu, Jiayi Wang, Lu Xie, Cong Peng, Liang Lin, Jie Li

2w ago

Visit website

Downregulation of otulin induces inflammasome activation in neutrophilic asthma

Journal of Allergy and Clinical Immunology

by Quang Luu Quoc, YeJi Kim, Gunwoo Park, Thi Bich Tra Cao, Youngwoo Choi, Yong Hwan Park, Hae-Sim Park

2w ago