Thyroid Nodule Development Linked to Overweight Among Children
Endocrinology Advisor
by melissaalvarez
23h ago
Incident thyroid nodules are associated with excessive weight among children, according to study findings published in the Journal of Clinical Endocrinology & Metabolism. Although the prevalence of thyroid nodules is relatively low among children and adolescents, up to 26% of reported cases carry the risk of malignancy. Previous research findings suggest a risk between incident thyroid nodules and obesity or overweight, but these studies do not establish causality. To investigate the longitudinal risk of thyroid nodule development among children with overweight and obesity, researchers in ..read more
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CGM Plus GLP-1 Therapy Improves HbA1c in Type 2 Diabetes
Endocrinology Advisor
by melissaalvarez
23h ago
Acquisition of a FreeStyle Libre continuous glucose monitor (CGM) is associated with significant improvements in glycated hemoglobin (HbA1c) among adults with type 2 diabetes receiving glucagon-like peptide-1 (GLP-1) therapy, according to study findings presented at the 17th International Conference on Advanced Technologies & Treatments for Diabetes held in Florence, Italy, on March 6, 2024. Although CGMs and GLP-1 therapy are both linked to glycemic improvements among adults with type 2 diabetes, the effect of their concurrent use is unknown. To determine whether use of a CGM as an adjunc ..read more
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Mothers Often Engage in Nonrecommended Practices for Infant Sleep
Endocrinology Advisor
by Haymarket Media
23h ago
HealthDay News — Mothers often engage in nonrecommended practices to improve their infant’s sleep, according to a study published online March 26 in Pediatrics. Rachel Y. Moon, M.D., from the University of Virginia School of Medicine in Charlottesville, and colleagues conducted surveys and focus groups from November 2022 to March 2023 with 25 English-speaking mothers of infants younger than 6 months of age who reported a nonrecommended sleep position and/or location two or more times in the previous week. The researchers found that 80 percent of mothers reported holding or rocking their i ..read more
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Patients With Rheumatoid Arthritis Face a Nearly 40% Greater Risk for Major Osteoporotic Fractures
Endocrinology Advisor
by Emily Estrada
23h ago
Patients with rheumatoid arthritis (RA) were associated with a nearly 40% increased risk for major osteoporotic fractures, although those receiving biological disease-modifying antirheumatic drugs (bDMARDs) may have a fracture risk comparable to individuals without RA, according to study results published in Rheumatic & Musculoskeletal Diseases Open. Rheumatoid arthritis is known to increase the risk for fragility fractures. While new treatments are greatly improving RA outcomes, whether these treatments are linked to reduced fracture risk is unknown. Researchers in Norway aimed to determi ..read more
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CKD Increasingly Underrepresented in Trials of Cardiovascular Disease Medications
Endocrinology Advisor
by Natasha Persaud
23h ago
Patients with chronic kidney disease (CKD) are increasingly excluded from randomized clinical trials (RCTs) of cardiovascular medications, a new study finds. Their “systematic exclusion” has led to substantial evidence gaps in using cardiovascular medications in this population. According to Robin W. M. Vernooij, PhD, of University Medical Center Utrecht in the Netherlands, and colleagues, “even though over 90% of patients with CKD are prescribed [cardiovascular risk management] medications, evidence is limited on the safety and effectiveness of these medications in this population.” As CKD pr ..read more
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Antidepressants for Late Life Depression Boost Memory, Learning in Older Adults
Endocrinology Advisor
by Meahjabeen Hoque
23h ago
Antidepressant pharmacotherapy for late-life depression (LLD) improves cognitive function in older adults, specifically in domains of memory and learning. These improvements are likely due, in part, to the improvement of depressive symptoms, according to study results published in The American Journal of Psychiatry. Previous research has shown that LLD is frequently reported in older adults and is a major driver of morbidity. Although antidepressants have been effective in treating LLD, it is unclear whether antidepressant pharmacotherapy affects cognitive function in this population and there ..read more
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Paxlovid Lowers COVID-19 Hospitalization Risk Even in Vaccinated Patients
Endocrinology Advisor
by Emily Estrada
23h ago
Paxlovid (nirmatrelvir-ritonavir) provides protection against hospitalization in high-risk adults with COVID-19, including those who are vaccinated, according to a study in Clinical Infectious Diseases. The retrospective analysis sought to estimate the stepwise benefit of monovalent vaccination and Paxlovid for preventing COVID-19 hospitalization. Data were obtained from the Cosmos dataset, which included more than160 million individuals using health care in the US. Eligible participants were nonpregnant adults who were either aged 50 and older or at least 18 years of age with an underlying he ..read more
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Tirzepatide vs Semaglutide Linked to Lower Metabolic Syndrome Prevalence
Endocrinology Advisor
by melissaalvarez
2d ago
Use of tirzepatide, compared with placebo, semaglutide, and insulin degludec and glargine, is associated with a lower prevalence of metabolic syndrome among patients with type 2 diabetes, according to results of a post hoc analysis published in Cardiovascular Diabetology. In the SURPASS clinical trial program (SURPASS 1-5; ClinicalTrials.gov; Identifiers: NCT03954834, NCT03987919, NCT03882970, NCT03730662, NCT04039503), the effect of tirzepatide for reducing glycated hemoglobin (HbA1c) and body weight among patients with type 2 diabetes was evaluated. Compared with placebo, semaglutide 1 mg, a ..read more
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Eli Lilly Reports Temporary Shortage of Humalog and Insulin Lispro Injection
Endocrinology Advisor
by Haymarket Media
2d ago
HealthDay News — Eli Lilly & Co. announced on Friday a temporary shortage of two of its insulin products. “The 10 mL vials of Humalog and Insulin Lispro Injection are or will be temporarily out of stock at wholesalers and some pharmacies through the beginning of April,” Lilly said in a recent statement. The company added it is continuing to make the 10-mL vials and “will ship them as soon as we can.” However, in the meantime, patients with diabetes may need to consult with their doctors “to discuss switching to the same insulin in a prefilled pen or other insulin treatment options.” S ..read more
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MRI-Guided TULSA Effective at 5 Years for Localized Prostate Cancer
Endocrinology Advisor
by Haymarket Media
2d ago
HealthDay News — For the treatment of localized prostate cancer, in-bore, magnetic resonance imaging (MRI)-guided transurethral ultrasound ablation (TULSA) results in favorable outcomes at five years, including durable oncologic control and functional preservation, according to a study presented at the annual meeting of the Society of Interventional Radiology, held from March 23 to 28 in Salt Lake City. Steven Raman, M.D., from the David Geffen School of Medicine at the University of California in Los Angeles, and colleagues evaluated the safety, quality of life, and oncological outcomes ..read more
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