Neurocrine Biosciences, Inc. on July 1 announced the U.S. Food and Drug Administration (FDA) has accepted its two New Drug Applications (NDA) with Priority Review designations for crinecerfont in the treatment of children, adolescents, and adults with classic congenital adrenal hyperplasia (CAH). If approved, crinecerfont would be the first new treatment option for CAH in... The post Neurocrine Biosciences Announces U.S. FDA Accepts New Drug Applications and Grants Priority Review for Crinecerfont for Pediatric and Adult Patients with CAH appeared first on Endocrine News ..read more

Exposure to some endocrine-disrupting chemicals (EDCs) that harm the thyroid gland has increased over the past 20 years among U.S. women of childbearing age and pregnant women, especially among those with lower social and economic status, according to a study presented at ENDO 2024. The researchers focused this study on women who may be particularly... The post Low Socioeconomic Status Raises Pregnant Women’s Risk of Exposure to Thyroid-Disrupting Chemicals appeared first on Endocrine News ..read more

An Endocrine News roundup of the week’s pharmaceutical news, breakthroughs, and general information. * Genentech Announces Positive Phase I Results of Its Oral GLP-1 Receptor Agonist CT-996 for the Treatment of People With Obesity On July 17, Genentech, a member of the Roche Group, announced positive topline results from two arms of an ongoing multi-part Phase I clinical trial for CT-996, an investigational, once-daily, oral small molecule GLP-1 receptor agonist being developed for the treatment of both type 2 diabetes and obesity.  The data showed that treatment with CT-996 in participan ..read more

As endocrinology fellowships go unfilled, leaders in the field are growing more concerned about the ability for endocrinology to meet the needs of future patients grappling with diabetes, obesity, and other endocrine disorders. To mitigate this potential gap, the Endocrine Society launched the Medical School Engagement Program (MSEP) to boost the interest of medical students across the country. In 2014, a paper by Vigersky et al. appeared in The Journal of Clinical Endocrinology & Metabolism that concluded, “There are insufficient adult endocrinologists to satisfy current and fut ..read more

Discussing endocrine science with the 2024 Early Investigator Award Winners Every year the Endocrine Society recognizes endocrinologists who are in the early stages of their research careers with the Early Investigator Awards. Endocrine News spoke to the five award recipients from around the world to find out more about their award-winning research, the award’s potential impact, as well as the biggest challenges facing them today. When the recipients of the Endocrine Society’s 2024 Early Investigator Awards presented their research at ENDO 2024, the atmosphere was electric and filled with anti ..read more

Many of us are now fully back at our day job having returned from last month’s ENDO in Boston. The meeting was a fabulous success. There was such a buzz around the conference center, where friends and colleagues, old and new, met to discuss the very best in science and clinical practice. Congratulations and a fantastic job well done must go to Immediate Past- President Steve Hammes, ENDO 2024 Chair Lauren Fishbein, the other chairs and the whole of the Annual Meeting Steering Committee, and all the dedicated and amazing staff who worked tirelessly to deliver this superb event. A key theme wove ..read more

When his grandmother succumbed to a heart attack when he was only eight years old, Joshua J. Joseph, MD, MPH, was determined to end as much suffering as he could. The recipient of the Endocrine Society’s 2024 Richard E. Weitzman Outstanding Early Career Investigator Award, he details his ongoing endeavors to make sure Black Americans have equal access to healthcare and be more inspired to join the medical profession. Early life experiences often have an indelible impact on choices we make later in life. For Joshua J. Joseph, MD, MPH, the pain of losing his grandmother to a heart attack after m ..read more

The type of weight loss surgery women undergo before becoming pregnant may affect how much weight their children gain in the first three years of life, according to a study presented at ENDO 2024.   Researchers found children born to women who underwent sleeve gastrectomy before they became pregnant gain more weight per month on average in the first three years of life compared with children born to women who had Roux-en-Y gastric bypass. “Either the extent of pre-pregnancy weight loss or the metabolic changes from Roux-en-Y gastric bypass may be favorable for the children’s early child ..read more

Fourth-year graduate student Tanya Pierre at the University of Alabama at Birmingham’s Comprehensive Diabetes Center talks to Endocrine News about when she realized that she could “do science” as a career, how she hopes her research will help her community, and the importance of awards to help young researchers continue their work. For many young researchers, working to unlock the mysteries of diseases is coupled with balancing the financial burdens of educational and laboratory expenses. But for Tanya Pierre, a fourth-year graduate student at the University of Alabama at Birmingham (UAB), the ..read more

Children who are sedentary for more than six waking hours a day have a significantly increased risk of severe fatty liver disease and liver cirrhosis by young adulthood, according to a study presented at ENDO 2024 and published in Nature’s npj Gut and Liver. “We found that this relationship between sedentariness and liver damage is likely causal,” says study author Andrew Agbaje, MD, MPH, PhD, of the University of Eastern Finland in Kuopio, Finland. Agbaje points out in his article that evidence on the long-term relationship of sedentary time (ST), light physical activity (LPA) and moder ..read more