European Urology
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European Urology, The Platinum Journal, published continuously since 1975, is an international peer-reviewed journal devoted to urology and related sciences and is published monthly. European Urology is the official journal of the European Association of Urology (EAU), a scientific society with more than 15,000 members from 120 countries worldwide.
European Urology
2d ago
The 2024 EAU-EANM-ESTRO-ESUR-ISUP-SIOG guidelines for prostate cancer recommend a targeted and perilesional biopsy (TPLBx) strategy for primary diagnosis. In comparison to the classical approach of combined targeted and systematic biopsy, TPLBx may reduce overdiagnosis of insignificant cancers and mitigate the grade shift associated with targeted biopsy ..read more
European Urology
4d ago
Molecular imaging probes for clear cell renal cell carcinoma (ccRCC) mainly target carbonic anhydrase IX (CA-IX) because of the high positivity rate. Radiotracers targeting CA-IX, such as 89Zr-girentuximab and 68Ga-DPI-4452, are used in clinical trials. However, physiological CA-IX expression in the gastrointestinal tract may complicate reading of images and limit the therapeutic potential of the radiopharmaceuticals [1,2]. In comparison, >80% of ccRCCs are CD70-positive, with minimal expression in normal tissues and organs ..read more
European Urology
1w ago
The number of therapeutic options continues to increase for men with high-risk localized prostate cancer [1]. Risk stratification within a given National Comprehensive Cancer Network (NCCN) risk group remains challenging [2]. ArteraAI Prostate, a multimodal artificial intelligence (MMAI) prognostic biomarker, was developed and validated using data from randomized trials in localized prostate cancer for prognostication of multiple clinically relevant endpoints [3]. Here we report the performance of this MMAI biomarker for men with high-risk prostate cancer from six phase 3 randomized trials ..read more
European Urology
1w ago
Dr. Niclas C. Blessin and his team conducted a comprehensive automated multicolor fluorescence quantitative analysis of a large bladder cancer (BC) tissue microarray (TMA; n = 2463), assessing 21 protein markers to explore the spatial relationships and prognostic implications of major immune-cell subsets in BC, particularly in muscle-invasive BC (MIBC) [1]. In the MIBC subset (n = 1159, with prognostic data available for 521 cases), four immune subtypes were identified that exhibited distinct patterns of immune-cell infiltration and immune checkpoint (IC) expression that we ..read more