Microorganisms live in or on almost every part of the human body and play an important role in the regulation of normal human processes. As a result, changes in the number or type of microorganisms, also known as the microbiome, can contribute to disease and altered responses to therapy, including cancer treatment. In a new study published ..read more

Although chimeric antigen receptor (CAR) T cell therapy has shown potential in the treatment of haematological malignancies, its application in solid tumours is unsatisfactory owing to the harsh physical barriers and immunosuppressive microenvironment. The ideal CAR T therapy requires a novel armoured CAR T cell engineered to navigate in the circulatory system, penetrate tumour tissues ..read more

Olga C. Pandos, University of Adelaide Hundreds of experts from around the world gathered at the Francis Crick Institute in London this week for the Third International Summit on Human Genome Editing. As at the first and second summits, held in Washington DC in 2015 and Hong Kong in 2018, leading experts in research shared ..read more

A small portion of adults in remission from a deadly blood cancer had persisting mutations that were detected, which predicted their risk of death from having the cancer return Researchers at the National Institutes of Health show the benefits of screening adult patients in remission from acute myeloid leukaemia (AML) for residual disease before receiving a bone marrow transplant. The findings, published in JAMA, support ongoing ..read more

A research team, affiliated with UNIST has unveiled a key factor involved in the DNA damage response, homologous recombination (HR) and DNA interstrand crosslink (ICL) repair. According to the research team, their findings are expected to establish an effective control environment for chromosome instability, a major factor in cancer evolution, and further help combat malignant tumours. Published in the January 2023 ..read more

Macrophages are highly specialised cells of the immune system that help the body detect and fight deadly pathogens. In particular, M1-like macrophages detect and destroy tumour cells, and release protective chemokines such as interleukin (IL)-6 and tumour-necrosis factor α (TNF α), thus shielding the body from life-threatening pathologies like cancer. However, not all macrophages show ..read more

New research indicates that for patients with breast cancer, the cancer’s stage and receptor status can help clinicians predict whether and when cancer might recur after initial treatment. The findings are published by Wiley online in CANCER, a peer-reviewed journal of the American Cancer Society. For the study, Heather Neuman, MD, MS, of the University of Wisconsin, and ..read more

A total of 1,261,990 people will die from cancer in 2023 in the EU (EU-27). A further 172,314 people will die from the disease in the UK, according to new research published in the leading cancer journal Annals of Oncology. Researchers led by Carlo La Vecchia (MD), a professor at the University of Milan (Italy), estimate there ..read more

Researchers from across the globe have been challenged to form world-leading teams and tackle some of the largest roadblocks in cancer research with funding awards of up to £20 million offered by major initiative, Cancer Grand Challenges. Founded in 2020 by Cancer Research UK and the National Cancer Institute (NCI), part of the National Institutes ..read more

For most Americans, the two major obstacles to proper medical care are time and money. And while insurance can sometimes reduce healthcare costs, having time to visit the doctor is just as important. Now, a new Tulane University study published in the New England Journal of Medicine has found that more people get screened for cancer when employers are ..read more