About 90% of deaths from cancer are a result of metastasis — that is, from cancer’s ability to spread from an initial primary tumour to seed new tumours throughout the body, often in the lungs, liver, and brain. And metastasis relies on cancer cells’ ability to adapt to different tissue environments throughout the body by ..read more

Certain proteogenomic signatures in the prostate cancers of men of African and European ancestries were associated with higher risk of metastasis and/or recurrence of the disease, according to a study presented at the American Association for Cancer Research (AACR) Annual Meeting 2024, held April 5-10. A study that combines proteomics and genomics is a field of ..read more

TG4050, a personalised neoantigen vaccine, induced tumour-specific immune responses and led to low rates of disease relapse in patients with surgically resected HPV-negative head and neck squamous cell cancer (HNSCC), according to results reported at the American Association for Cancer Research (AACR) Annual Meeting 2024, held April 5-10. Patients with locoregional HNSCC have a high risk of disease ..read more

A blood-based machine learning assay that combines cell-free DNA (cfDNA) fragment patterns and levels of the proteins CA125 and HE4 could differentiate patients with ovarian cancer from healthy controls or patients with benign ovarian masses, according to a retrospective study presented at the American Association for Cancer Research (AACR) Annual Meeting 2024, held April 5-10. Federal ..read more

AZD1390, an ataxia telangiectasia mutant (ATM) kinase inhibitor, demonstrated a manageable safety profile in both recurrent and newly diagnosed glioblastoma (GBM) patients when given in combination with standard-of-care radiotherapy and showed preliminary efficacy in recurrent GBM patients, according to results from a global phase I trial presented at the American Association for Cancer Research (AACR) Annual Meeting 2024 ..read more

An investigational exosome-based liquid biopsy accurately detected 97% of stage 1-2 pancreatic cancers when combined with the biomarker CA 19-9, according to research presented at the American Association for Cancer Research (AACR) Annual Meeting 2024, held April 5-10. “Pancreatic cancer is one of the most fatal malignancies, in large part because the majority of patients are diagnosed ..read more

Despite having an overall survival rate of 94%, B-cell acute lymphoblastic leukaemia (B-ALL), the most common childhood cancer, can prove challenging to treat, with survival among relapsed or resistant cases falling between 30-50%. Recent work by St. Jude Children’s Research Hospital scientists discovered which tumour cells resist treatment and why. This enabled the rational design of a ..read more

In a recent study, researchers at Huntsman Cancer Institute at the University of Utah (the U), USA, found a surprising trend in families with male infertility: an increased risk of certain cancers. This discovery could lead to a more personalised approach to cancer risk assessments, making cancer prevention more effective. Published in the journal, Human Reproduction ..read more

The Phase 1/2 LINKER-MM1 trial of linvoseltamab in patients with relapsed/refractory (R/R) multiple myeloma (MM) was announced at the American Association for Cancer Research (AACR) Annual Meeting 2024 in San Diego. Linvoseltamab is an investigational bispecific antibody designed to bridge B-cell maturation antigen (BCMA) on multiple myeloma cells with CD3-expressing T cells to facilitate T-cell activation ..read more

In a study presented today at the American Association for Cancer Research (AACR) Annual Meeting 2024, researchers at Fox Chase Cancer Center showed that oestrogen is metabolised extensively in both mouse and human lungs, ultimately contributing to the development of lung cancer in people who have never smoked. Investigators at Fox Chase are the first to ..read more