Kinetic vs. thermodynamic control of β-functionalized cyclic ketones: a theoretical investigation of regioselective formation of enolatesManuel Petroselli* and Corrado BacchiocchiOrg. Chem. Front., 2022, 9, 6205-6212https://doi.org/10.1039/D2QO01343F Thermodynamic- and kinetic-controlled deprotonation of symmetric and asymmetric ketones is a well-known process that leads to the formation of enolates, one of the most important intermediate in organic chemistry. Regio-selective deprotonation assumes extreme importance, being critical to the success of organic reactions, when unsym ..read more

We are proud to announce the three best covers of Organic Chemistry Frontiers in 2023! The awarded works were chosen by our readers through a worldwide vote. To learn more about the science behind the winning pieces, read the cover articles below for free until 29 February 2024.  Ligand-assisted olefin-switched divergent oxidative Heck cascade with molecular oxygen enabled by self-assembled imines Bairong Liu, Jianhang Rao, Weibing Liu, Yang Gao, Yanping Huo, Qian Chen and Xianwei Li * Org. Chem. Front., 2023, 10, 2128-2137 https://doi.org/10.1039/D3QO00316G   Photo-induced nickel-m ..read more

We are delighted to announce the establishment of our inaugural Early Career Advisory Board at Organic Chemistry Frontiers. This initiative aims to provide a direct channel for engaging with early-career researchers, supporting their professional development, and infusing our journal with fresh innovative perspectives from the younger generation. We warmly invite you to nominate an emerging investigator to the board or encourage your colleagues to self-nominate before 30 November 2023. Role of the Early Career Advisory Board At Organic Chemistry Frontiers, we value the voices of early-career ..read more

Emerging Investigator: Chuan He Position          Associate Professor Postdoc          2013–2017  University of Cambridge Education       2008–2013  Wuhan University          Ph.D.                        2004–2008  Wuhan University          B.Sc. Group website        http://faculty.sustech.edu.cn/hec/en/ ORCID                  &nbs ..read more

Emerging Investigator: Michael C. Young Position          Associate Professor Postdoc          2014–2016  University of Texas at Austin Education       2009–2014  University of California, Riverside          Ph.D.                        2006–2008  Western Carolina University                   M.Sc.                     &nb ..read more

Oxidative Mizoroki–Heck reaction of unprotected cinnamylamines at ambient temperature under airOlutayo N. Farinde, Vanaparthi Satheesh, Kendra K. Shrestha, Carmen R. Rhinehalt, Vinod G. Landge and Michael C. YoungOrg. Chem. Front., 2023, 10, 3982-3988https://doi.org/10.1039/D3QO00778B Cinammylamines and 3,3-diarylallylamines represent an important class of molecules for drug discovery, and can serve as intermediates thanks to their olefin functionality which can lead to further elaboration. However, there are numerous challenges in the application of organometallic methods to synthesize h ..read more

Emerging Investigator: Liang-An Chen Position          Professor Education       2011–2014  Xiamen University                            Ph.D.                        2008–2011  Xiamen University                            M.Sc.                        2004–2008  Fuyang ..read more

Emerging Investigator: Guangfan Zheng Position          Associate Professor Education       2014–2017  Northeast Normal University                Ph.D.                        2012–2014  Northeast Normal University                M.Sc.                        2006–2010  Jilin University              ..read more

Cycloisomerization of 1,n-enynes provides a variety of cyclic compounds via multiple bond cleavage and formation. Since these processes are generally induced by alkyne π-bond activation, transition metal catalysts have been well studied for the selective construction of these cyclic products (Scheme 1A). However, transition metal catalysts can be hardly applied to electron-deficient alkynes having acyl groups or other relative strong electron-withdrawing groups. Since acyl groups can be converted to various functional groups, it is desirable to develop catalyst systems applicable to such start ..read more

We are proud to announce the three best covers of Organic Chemistry Frontiers in 2022! The awarded work was chosen by our readers through a worldwide vote. To learn more about the science behind the winning pieces, read the cover articles below. Ni(II)-Catalyzed intermolecular selective Heck-type arylation of unactivated alkenes with arylboronic acids Cong Lin,* Sai Chen, Yihua Wang, Fei Gao and Liang Shen* Org. Chem. Front., 2022, 9, 608-614 https://doi.org/10.1039/D1QO01579F   Palladium-catalyzed direct γ-C(sp3)–H arylation of β-alkoxy cyclohexenones: reaction scope and mechanistic ins ..read more