Research biopsies in kidney transplantation: an evaluation of surgical techniques and optimal tissue mass allowing molecular and histological analyses
BMC | Clinical Proteomics
by Sadr ul Shaheed, Hannah McGivern, Marta Oliveira, Corinna Snashall, Chris W. Sutton, Ka Ho Tam, Simon Knight, Syed Hussain Abbas, Jesper Kers, Sarah Cross, Rutger Ploeg and James Hunter
3d ago
Research biopsies have great potential to advance scientific knowledge by helping to establish predictors of favourable or unfavourable outcomes in kidney transplantation. We evaluated punch and core biopsies ..read more
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Using established biorepositories for emerging research questions: a feasibility study
BMC | Clinical Proteomics
by Lente J. S. Lerink, Christopher W. Sutton, Henny G. Otten, Letizia Lo Faro, Rutger J. Ploeg, Jan H. N. Lindeman and Sadr Shaheed
3w ago
Proteomics and metabolomics offer substantial potential for advancing kidney transplant research by providing versatile opportunities for gaining insights into the biomolecular processes occurring in donors, r ..read more
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Application of urine proteomics in the diagnosis and treatment effectiveness monitoring of early-stage Mycosis Fungoides
BMC | Clinical Proteomics
by Hongbin Song, Zhonghui Hu, Shiyu Zhang, Lu Yang, Jindi Feng, Lu Lu, Yuehua Liu and Tao Wang
1M ago
Mycosis fungoides (MF) is the most common type of cutaneous T cell lymphoma. As the early clinical manifestations of MF are non-specific (e.g., erythema or plaques), it is often misdiagnosed as inflammatory sk ..read more
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Quantitative proteomics reveals serum proteome alterations during metastatic disease progression in breast cancer patients
BMC | Clinical Proteomics
by Jaspreet Kaur, Sung Yun Jung, Marie Austdal, Aaditya Krishna Arun, Thomas Helland, Gunnar Mellgren, Tone Hoel Lende, Emiel A. M. Janssen, Håvard Søiland and Ritu Aneja
1M ago
Tumor recurrence and metastatic progression remains the leading cause for breast cancer related mortalities. However, the proteomes of patient- matched primary breast cancer (BC) and metastatic lesions have no ..read more
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Proteomic profile and predictive markers of outcome in patients with subarachnoid hemorrhage
BMC | Clinical Proteomics
by Sara Diana Lolansen, Nina Rostgaard, Markus Harboe Olsen, Maud Eline Ottenheijm, Lylia Drici, Tenna Capion, Nicolas Hernandez Nørager, Nanna MacAulay and Marianne Juhler
1M ago
The molecular mechanisms underlying development of posthemorrhagic hydrocephalus (PHH) following subarachnoid hemorrhage (SAH) remain incompletely understood. Consequently, treatment strategies tailored toward ..read more
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ESF1 and MIPEP proteins promote estrogen receptor-positive breast cancer proliferation and are associated with patient prognosis
BMC | Clinical Proteomics
by Qing Yu, Chunhua Qu, Jinliang Liang, Peiqi Chen, Kaiying Zhang, Yanji Zhang, Yuening Zhang, Zherui Li, Shaojun Liu, Zhaoshou Yang, Hongyan Sun and Anli Yang
2M ago
Estrogen receptor-positive (ER+) breast cancer accounts for two-thirds of all breast cancers, and its early and late recurrences still threaten patients’ long-term survival and quality of life. Finding candida ..read more
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Proteome profiling of cutaneous leishmaniasis lesions due to dermotropic Leishmania donovani in Sri Lanka
BMC | Clinical Proteomics
by Nuwani H. Manamperi, Nimesha Madhushani Edirisinghe, Harshima Wijesinghe, Lakmali Pathiraja, Nishantha Pathirana, Vishmi Samudika Wanasinghe, Chamalka Gimhani De Silva, W. Abeyewickreme and Nadira D. Karunaweera
2M ago
Characterization of the host response in cutaneous leishmaniasis (CL) through proteome profiling has gained limited insights into leishmaniasis research compared to that of the parasite. The primary objective ..read more
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A single-sample workflow for joint metabolomic and proteomic analysis of clinical specimens
BMC | Clinical Proteomics
by Hagen M. Gegner, Thomas Naake, Karim Aljakouch, Aurelien Dugourd, Georg Kliewer, Torsten Müller, Dustin Schilling, Marc A. Schneider, Nina Kunze-Rohrbach, Thomas G.P. Grünewald, Rüdiger Hell, Julio Saez-Rodriguez, Wolfgang Huber, Gernot Poschet and Jeroen Krijgsveld
2M ago
Understanding the interplay of the proteome and the metabolome helps to understand cellular regulation and response. To enable robust inferences from such multi-omics analyses, we introduced and evaluated a wo ..read more
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Effect of dynamic exclusion and the use of FAIMS, DIA and MALDI-mass spectrometry imaging with ion mobility on amyloid protein identification
BMC | Clinical Proteomics
by Jennifer T. Aguilan, Jihyeon Lim, Sabrina Racine-Brzostek, Joshua Fischer, Cristina Silvescu, Shannon Cornett, Edward Nieves, Damodara Rao Mendu, Carlos-Madrid Aliste, Stacia Semple, Ruth Angeletti, Louis M. Weiss, Adam Cole, Michael Prystowsky, James Pullman and Simone Sidoli
2M ago
Amyloidosis is a disease characterized by local and systemic extracellular deposition of amyloid protein fibrils where its excessive accumulation in tissues and resistance to degradation can lead to organ fail ..read more
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Resistin as a potential diagnostic biomarker for sepsis: insights from DIA and ELISA analyses
BMC | Clinical Proteomics
by Youyu Lan, Wentao Guo, Wenhao Chen, Muhu Chen and Shaolan Li
2M ago
The primary objective of this investigation is to systematically screen and identify differentially expressed proteins (DEPs) within the plasma of individuals afflicted with sepsis. This endeavor employs both ..read more
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