Dr. Cecilia Lindskog, a research group leader at Uppsala University and director of the Uppsala site of the HPA project, has been awarded the 2024 Erik K. Fernström Foundation's Prize for young, particularly promising researchers ..read more

Female fertility relies on the ovarian follicles that form during fetal development. Some medical treatments, such as chemo- or radiotherapy, are toxic to follicles and therefore ovarian tissue cryopreservation is used as a standard method for fertility preservation. This method is used for both adults and prepubertal individuals, even if its efficiency for tissue collected before puberty is not well documented ..read more

Histone-like protein Protamine 1 (gene: PRM1) is visualized in the late stage cell states of developing sperm in testis with multiplex immunohistochemistry (mIHC/IF ..read more

Previously, it was believed that the presence of an oncogenic mutation within a cell was sufficient to drive tumour development. However, it is now understood that tissues may contain cells harbouring oncogenic mutations, but that these cells maintain a normal phenotype until an initiating factor promotes oncogenic transformation (Acha-Sagredo et al, 2021). Changes in the cellular milieu and tissue architecture, such as inflammation or parenchymal density, are thought to alter the behaviour of these cells, affecting the likelihood of oncogenic transformation (Ling et al, 2020; Singh et al, 201 ..read more

G-protein coupled receptors (GPCRs) are a large family of cell surface receptors important for activating cellular responses. They are activated by many types of signals like light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters and are involved in a wide range of diseases which have made them important drug targets. Receptor activity-modifying proteins (RAMPs) form complexes with the GPCRs and may regulate their cellular trafficking and pharmacology ..read more

NKG2D (Natural Killer Group 2, member D) is an activating receptor expressed in the cytotoxic branch of the immune system, primarily on the surface of Natural Killer (NK), CD8+, and certain subsets of NK-, γδ-, and CD4+ T cells (Raulet, 2023). Its capacity to activate immune effectors without the need for antigen presentation makes the NKG2D receptor a major component of our first-line defense against both neoplastic development and external pathogens ..read more

Two dipeptidase proteins with different tissue specificity are displayed through multiplex immunohistochemistry (mIHC/IF ..read more

Among the about 20,000 genes in the human proteome there are still many rather unknown but potentially interesting proteins that deserve some extra attention. Here we will focus on C10orf53, a gene specifically expressed in the testis ..read more

Indoleamine 2,3-dioxygenase 1 (IDO1) catalyzes the first and rate-limiting step in the kynurenine pathway, which converts the essential amino acid tryptophan into kynurenine and other metabolites (Ball, 2014). This enzymatic activity exerts significant immunoregulatory effects, which has made it an attractive target for immunotherapy research ..read more

The difference in spatial distributions of two aquaporin proteins in the cells of collecting ducts in the kidney is illuminated through multiplex immunohistochemistry (mIHC/IF ..read more