Abstract figure legend Hypoxia-inducible factor (HIF) is a critical therapeutic target that can potentially improve acute respiratory distress syndrome (ARDS) outcomes. ARDS causes a significant burden on the healthcare system worldwide, with the sobering incidence of 23.4% of ARDS patients in intensive care units requiring mechanical ventilation, 66% of patients having a delayed diagnosis and 40% of cases being entirely unrecognized. The mortality risk was found to be 40%. In longitudinal studies, 40% of ARDS patients are readmitted by 1 year and 83% by 5 years. To date, we still do not have ..read more

Abstract figure legend Role of MICU3 in skeletal muscle physiology. Deletion of MICU3 leads to a decline in exercise capacity in mice, along with an accelerated onset of muscle fatigue. The mitochondria from skeletal muscle lacking MICU3 exhibited lower calcium uptake. Furthermore, skeletal muscle from MICU3-KO mice shows reduced net oxidation of NADH and membrane potential (ΔΨ) during electrically stimulated muscle contraction in comparison to wild-type mice. These findings collectively underscore the important role of MICU3 in regulating mitochondrial calcium uptake, which impacts the synch ..read more

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Abstract figure legend Simultaneous control of forward and backward locomotion by spinal sensorimotor circuits. Sensory feedback from the hindimbs interacts with neuronal circuits of the lumbosacral cord to coordinate the left and right hindlimbs, allowing one hindlimb to step forward while the other steps backward on a split-belt treadmill. Abstract Mammals walk in different directions, such as forward and backward. In human infants/adults and decerebrate cats, one leg can walk forward and the other backward simultaneously on a split-belt treadmill, termed hybrid or bidirectional locomotion ..read more

Abstract figure legend Exercise training can be used as a non-pharmacological treatment to halt, or at least reduce, the progression of the cardiovascular and metabolic derangements that compose the metabolic syndrome. Recent studies using intense interval training have spurred interest in other exercise factors that may increase exercise training effectiveness. For example, the time of day at which training takes place could modulate the health outcome. The present study randomly assigned 175 individuals with metabolic syndrome to train in the morning or afternoon, or to remain untrained. Th ..read more

Abstract figure legend Contribution of excessive mitochondrial Ca2+ uptake to amyotrophic lateral sclerosis (ALS) pathology. Left, under physiological condition, mitochondria located in different tissues (from top to bottom: upper motor neuron, astrocytes, lower motor neurons, neuromuscular junction (NMJ) and skeletal muscle) take up Ca2+ during neuronal and muscle activity and produce ATP through oxidative phosphorylation to support physiological activities of the cells. Right, under diseased condition, mitochondria in the same tissues take up excessive amount of Ca2+ during neuronal and mus ..read more

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Abstract figure legend Electrical slow waves recorded directly from ICC-MY of the Guinea pig gastric antrum. A, interval between slow waves: small amplitude spontaneous transient depolarizations (STDs) summate to generate upstroke. B, upstroke phase: activation of voltage-dependent Ca2+ conductance and Ca2+ entry. C, plateau phase: Ca2+ entry initiates Ca2+-induced Ca2+ release and activation of Ca2+-activated Cl− conductance (ANO1 or a Ca2+-dependent non-selective cation conductance). D, repolarization: when Ca2+ release from ER is exhausted, ANO1 is deactivated and cells repolarize to the i ..read more

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Abstract Figure legend Fetal growth restriction (FGR) results in altered cardiac metabolism in the late gestation fetus. This includes reduced glucose and fatty acid transporter expression, which has downstream effects on molecular markers of metabolism, including lower abundance of mitochondria and complexes II and IV of the electron transport chain (ETC). Abstract Babies born with fetal growth restriction (FGR) are at higher risk of developing cardiometabolic diseases across the life course. The reduction in substrate supply to the developing fetus that causes FGR not only alters cardiac g ..read more