Multi-omics association study of DNA methylation and gene expression levels and diagnoses of cardiovascular diseases in Danish Twins
Clinical Epigenetics
by Asmus Cosmos Skovgaard, Afsaneh Mohammadnejad, Hans Christian Beck, Qihua Tan and Mette Soerensen
1w ago
Cardiovascular diseases (CVDs) are major causes of mortality and morbidity worldwide; yet the understanding of their molecular basis is incomplete. Multi-omics studies have significant potential to uncover the ..read more
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Biological aging mediates the association between periodontitis and cardiovascular disease: results from a national population study and Mendelian randomization analysis
Clinical Epigenetics
by Zhaoqi Zhang, Xingru Zhao, Shang Gao, An Li, Ke Deng, Kai Yang, Wei Liu and Mi Du
2w ago
The relationship between periodontitis and cardiovascular disease (CVD) has been extensively studied, but the role of biological aging in this relationship remains poorly understood. This study is dedicated to ..read more
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DNA methylation in cardiovascular disease and heart failure: novel prediction models?
Clinical Epigenetics
by Antonella Desiderio, Monica Pastorino, Michele Campitelli, Michele Longo, Claudia Miele, Raffaele Napoli, Francesco Beguinot and Gregory Alexander Raciti
2w ago
Cardiovascular diseases (CVD) affect over half a billion people worldwide and are the leading cause of global deaths. In particular, due to population aging and worldwide spreading of risk factors, the prevale ..read more
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MIR124-3 and NKX6-1 hypermethylation profiles accurately predict metachronous gastric lesions in a Caucasian population
Clinical Epigenetics
by Catarina Lopes, Tatiana C. Almeida, Catarina Macedo-Silva, João Costa, Sofia Paulino, Carmen Jerónimo, Diogo Libânio, Mário Dinis-Ribeiro and Carina Pereira
2w ago
Early gastric cancer is treated endoscopically, but patients require surveillance due to the risk of metachronous gastric lesions (MGLs). Epigenetic alterations, particularly aberrant DNA methylation in genes ..read more
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The response to influenza vaccination is associated with DNA methylation-driven regulation of T cell innate antiviral pathways
Clinical Epigenetics
by Hongxiang Fu, Harry Pickering, Liudmilla Rubbi, Ted M. Ross, Wanding Zhou, Elaine F. Reed and Matteo Pellegrini
2w ago
The effect of vaccination on the epigenome remains poorly characterized. In previous research, we identified an association between seroprotection against influenza and DNA methylation at sites associated with ..read more
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Exposure-associated DNA methylation among people exposed to multiple industrial pollutants
Clinical Epigenetics
by Chi-Hsin Sally Chen, Tzu-Hsuen Yuan, Tzu-Pin Lu, Hsin-Ying Lee, Yi-Hsuen Chen, Liang-Chuan Lai, Mong-Hsun Tsai, Eric Y. Chuang and Chang-Chuan Chan
2w ago
Current research on the epigenetic repercussions of exposure to a combination of pollutants is limited. This study aims to discern DNA methylation probes associated with exposure to multiple pollutants, servin ..read more
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Epigenetic patterns, accelerated biological aging, and enhanced epigenetic drift detected 6 months following COVID-19 infection: insights from a genome-wide DNA methylation study
Clinical Epigenetics
by Calzari Luciano, Dragani Davide Fernando, Zanotti Lucia, Inglese Elvira, Danesi Romano, Cavagnola Rebecca, Brusati Alberto, Ranucci Francesco, Di Blasio Anna Maria, Persani Luca, Campi Irene, De Martino Sara, Farsetti Antonella, Barbi Veronica, Gottardi Zamperla Michela, Baldrighi Giulia Nicole…
2w ago
The epigenetic status of patients 6-month post-COVID-19 infection remains largely unexplored. The existence of long-COVID, or post-acute sequelae of SARS-CoV-2 infection (PASC), suggests potential long-term ch ..read more
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HDAC6 inhibition disrupts HDAC6-P300 interaction reshaping the cancer chromatin landscape
Clinical Epigenetics
by Michela Gottardi Zamperla, Barbara Illi, Veronica Barbi, Chiara Cencioni, Daniele Santoni, Stella Gagliardi, Maria Garofalo, Gabriele Antonio Zingale, Irene Pandino, Diego Sbardella, Lina Cipolla, Simone Sabbioneda, Antonella Farsetti, Chiara Ripamonti, Gianluca Fossati, Christian Steinkühler…
2w ago
Histone deacetylases (HDACs) are crucial regulators of gene expression, DNA synthesis, and cellular processes, making them essential targets in cancer research. HDAC6, specifically, influences protein stabilit ..read more
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Triage performance of PAX1m/JAM3m in opportunistic cervical cancer screening of non‒16/18 human papillomavirus-positive women: a multicenter prospective study in China
Clinical Epigenetics
by Xiaojing Chen, Xitong Jin, Linghua Kong, Yuligh Liou, Pei Liu, Zhe Dong, Sijun Zhou, Bingli Qi, Jing Fei, Xiaoyan Chen, Guangwu Xiong, Yuchong Hu, Shikai Liu, Jianwei Zhou, Huafeng Shou and Lei Li
2w ago
In this study, we aimed to validate the performance of the PAX1 and JAM3 methylation (PAX1m/JAM3m) test as a triage tool for detecting cervical intraepithelial neoplasia grade 3 or worse (CIN3 +) in non-16/18 hig ..read more
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Mendelian randomization implicates causal association between epigenetic age acceleration and age-related eye diseases or glaucoma endophenotypes
Clinical Epigenetics
by Jiawei Chen, Xiang-Ling Yuan, Xiaoyu Zhou, Jiahao Xu, Xinyue Zhang and Xuanchu Duan
2w ago
Age-related eye diseases (AREDs) have become increasingly prevalent with the aging population, serving as the leading causes of visual impairment worldwide. Epigenetic clocks are generated based on DNA methyla ..read more
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