A 2024 rodent study investigated epigenetic effects of loosening compacted chromatin: “We show using a novel mouse strain, (TKOc), carrying a triple knockout of three methyltransferases responsible for H3K9me3 deposition, that the inducible loss of H3K9me3 in adulthood results in premature aging. TKOc mice exhibit: Reduced lifespan; Lower body weight; Increased frailty index; Multi-organ degeneration ..read more

A 2024 preprint published results of feasibility trial NCT03878368: “High glucosinolate broccoli soup is a novel approach to managing osteoarthritis (OA) that is widely accessible and can be used on a large scale. This study shows that it is an acceptable way of delivering dietary bioactives and has potential for therapeutic benefit. Limitations of the ..read more

Two+ decades ago (before smart phones) I wrote a series of short books entitled How To Choose Your  Lawyer, ..Accountant, ..Financial Advisor. My customers were mainly public libraries. This is a short post on choosing doctors, although I’ve fired all my doctors and don’t have one. Everything that’s happened this decade has made me wonder ..read more

A 2024 rodent study investigated sulforaphane’s effects on skeletal muscle: “Sulforaphane (SFN) shows a promising application in skeletal muscle protection and recovery from muscle atrophy and damage. However, limited work has focused on the role of SFN in maintaining the balance of protein and lipid metabolism in skeletal muscle. The current work investigates effects of ..read more

A 2024 rodent study followed up earlier studies of perinatal stress: “Stress is a multisystemic and multiscale reaction experienced by living beings in response to a wide range of stimuli, encompassing a highly complex order of biological and behavioral responses in mammals, including humans. In the present study, we evaluated changes in mRNA levels in ..read more

Got agitated earlier this week watching Tucker Carlson’s freely-available interview with a maniac who thinks he’s graduated into a higher state by worshiping the Great AI (Artificial Intelligence, aka Automated Internet, inhabited solely by robots) which will dictate every aspect of what to do with his life. Nevermind that behind the Great AI curtain are ..read more

A 2024 Dr. Goodenowe presentation to a professional audience. He ended the presentation by using his 86-year-old father as a case study of treatment to create an inhospitable environment for cancer. 1. Get the body ready 2. Starve the cancer and boost the immune system 3. Characteristics 4. 2019 sample biochemistry 5. 2023 biochemistry (compare ..read more

Two more papers cited Precondition your defenses with broccoli sprouts, starting with a 2024 review of broccoli compounds’ influences on autophagy and cellular function: “Promotion of autophagy has been related to lifespan expansion, tumor suppression, and maintenance of metabolic health. Alterations in this pathway have been related to human diseases or pathological states including neurodegenerative ..read more

1. I’ve continued daily practices from Year Three to experience another year without being sick. I’ll get a set of Labcorp tests in two weeks to see if anything is sneaking up on me. Foods are the same as Week 189 except I eat two raw eggs in the morning after Avena sativa oat sprouts. Supplements ..read more

Continuing Part 1 with a 2024 rodent healthspan and lifespan study: “We investigated the effects of daily oral supplementation of ergothioneine (ERGO) dissolved in drinking water on lifespan, frailty, and cognitive impairment in male mice from 7 weeks of age to the end of their lives. Ingestion of 4 ~ 5 mg/kg/day of ERGO remarkably extended the ..read more