Got agitated earlier this week watching Tucker Carlson’s freely-available interview with a maniac who thinks he’s graduated into a higher state by worshiping the Great AI (Artificial Intelligence, aka Automated Internet, inhabited solely by robots) which will dictate every aspect of what to do with his life. Nevermind that behind the Great AI curtain are ..read more

A 2024 Dr. Goodenowe presentation to a professional audience. He ended the presentation by using his 86-year-old father as a case study of treatment to create an inhospitable environment for cancer. 1. Get the body ready 2. Starve the cancer and boost the immune system 3. Characteristics 4. 2019 sample biochemistry 5. 2023 biochemistry (compare ..read more

Two more papers cited Precondition your defenses with broccoli sprouts, starting with a 2024 review of broccoli compounds’ influences on autophagy and cellular function: “Promotion of autophagy has been related to lifespan expansion, tumor suppression, and maintenance of metabolic health. Alterations in this pathway have been related to human diseases or pathological states including neurodegenerative ..read more

1. I’ve continued daily practices from Year Three to experience another year without being sick. I’ll get a set of Labcorp tests in two weeks to see if anything is sneaking up on me. Foods are the same as Week 189 except I eat two raw eggs in the morning after Avena sativa oat sprouts. Supplements ..read more

Continuing Part 1 with a 2024 rodent healthspan and lifespan study: “We investigated the effects of daily oral supplementation of ergothioneine (ERGO) dissolved in drinking water on lifespan, frailty, and cognitive impairment in male mice from 7 weeks of age to the end of their lives. Ingestion of 4 ~ 5 mg/kg/day of ERGO remarkably extended the ..read more

Here are two more papers that cited Precondition your defenses with broccoli sprouts, starting with a 2024 human / rodent study investigating gut microbiota / sulforaphane’s effects on autism: “Sulforaphane (SFN) has been found to alleviate complications linked with several diseases by regulating gut microbiota (GM), while the effect of GM on SFN for autism ..read more

A 2024 review provided details about “mysteries” in peroxisome research: “Peroxisomes are key metabolic organelles with essential functions in cellular lipid metabolism (e.g., β-oxidation of fatty acids and synthesis of ether phospholipids, which contribute to myelin sheath formation), and metabolism of reactive oxygen species (ROS), particularly hydrogen peroxide. Loss of peroxisomal function causes severe metabolic ..read more

Two reviews on beneficial effects of mild stress, starting with a 2024 paper coauthored by the lead researcher of Sulforaphane in the Goldilocks zone: “This paper addresses how long lifespan can be extended via multiple interventions, such as dietary supplements, pharmaceutical agents, caloric restriction, intermittent fasting, exercise, and other activities. This evaluation was framed within ..read more

Four 2023 papers that cited Part 1, starting with a review of hypothetical parameters for taurine clinical trials that aren’t going to happen because: Drug companies can’t make money from a research area that’s cheap, not patentable, and readily accessible. Government sponsors are likewise not incentivized to act in the public’s interest per their recent ..read more

Eight 2023 acetyl-L-carnitine / L-carnitine papers, starting with three healthy human studies: “Thirty healthy volunteers aged between 19 and 52 years were divided randomly into two equal groups, one of which received 1000 mg of L-carnitine (LC) per day over a 12-week period. Total cholesterol and HDL-C increased significantly after supplementation. LC could be useful ..read more