Correction to: The Largest Subunit of Human TFIIIC Complex, TFIIIC220, a Lysine Acetyltransferase Targets Histone H3K18
Oxford Academic - The Journal of Biochemistry
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2M ago
This is a correction to: Moumita Basu, Rohini Bhatt, Anjali Sharma, Ramachandran Boopathi,Sadhan Das, Tapas K Kundu, The Largest Subunit of Human TFIIIC Complex, TFIIIC220, a Lysine Acetyltransferase Targets Histone H3K18, The Journal of Biochemistry, Volume 175, Issue 2, February 2024, Pages 205–213, https://doi.org/10.1093/jb/mvad088 ..read more
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Relationships between protein degradation, cellular senescence, and organismal aging
Oxford Academic - The Journal of Biochemistry
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2M ago
Abstract Aging is a major risk factor for many diseases. Recent studies have shown that age-related disruption of proteostasis leads to the accumulation of abnormal proteins and that dysfunction of the two major intracellular proteolytic pathways, the ubiquitin-proteasome pathway, and the autophagy-lysosome pathway, is largely responsible for this process. Conversely, it has been shown that activation of these proteolytic pathways may contribute to lifespan extension and suppression of pathological conditions, making it a promising intervention for anti-aging. This review provides an overview ..read more
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Protein homeostasis and degradation in quiescent neural stem cells
Oxford Academic - The Journal of Biochemistry
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2M ago
Abstract Tissue stem cells are maintained in the adult body throughout life and are crucial for tissue homeostasis as they supply newly functional cells. Quiescence is a reversible arrest in the G0/G1 phase of the cell cycle and a strategy to maintain the quality of tissue stem cells. Quiescence maintains stem cells in a self-renewable and differentiable state for a prolonged period by suppressing energy consumption and cell damage and depletion. Most adult neural stem cells in the brain maintain the quiescent state and produce neurons and glial cells through differentiation after activating f ..read more
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On the pursuit to reconstitute the Escherichia coli ribosome from purified components
Oxford Academic - The Journal of Biochemistry
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2M ago
Abstract The ribosome, the protein synthesizing machinery composed of dozens of proteins and several ribosomal RNAs (rRNAs), is essential for life. In vitro reconstitution of the ribosome holds significance for understanding biosynthesis, applications in biotechnology and potential contributions to synthetic biology. There is a long history of in vitro reconstitution of bacterial ribosomes, originating in the 1970s when the 30S ribosome of Escherichia coli was reconstituted from the protein and rRNA components prepared from native ribosome. Since then, the reconstitution using in vitro transcr ..read more
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Comparative Analysis of Site-Specific N-glycosylation of LAMP1 from Breast Cancer Tissues
Oxford Academic - The Journal of Biochemistry
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2M ago
Abstract Glycosylation changes in cancer proteins have been associated with malignant transformation. However, techniques for analyzing site-specific glycosylation changes in target proteins obtained from clinical tissue samples are insufficient. To overcome these problems, we developed a targeted N-glycoproteomic approach consisting of immunoprecipitation, glycopeptide enrichment, LC/MS/MS and structural assignment using commercially available analytical software followed by manual confirmation. This approach was applied to the comparative site-specific glycosylation analysis of lysosome-asso ..read more
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Notch signaling pathway induces expression of type IV collagen in angiogenesis
Oxford Academic - The Journal of Biochemistry
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2M ago
Abstract Mural cell adhesion is important for the localization of basement membrane components during angiogenesis, and cell–cell interactions are thought to be critical for basement membrane formation. Type IV collagen, a component of the basement membrane, and non-triple helical type IV collagen α1 chain (NTH α1(IV)) co-localize in the basement membrane of neovascular vessels. However, it remains unclear how type IV collagen and NTH α1(IV) are produced around the basement membrane. In the present study, we developed a de novo angiogenesis model using human umbilical vein endothelial cell sph ..read more
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Perturbed collagen metabolism underlies lymphatic recanalization failure in Gata2 heterozygous deficient mice
Oxford Academic - The Journal of Biochemistry
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2M ago
Abstract Lymphedema has become a global health issue following the growing number of cancer surgeries. Curative or supportive therapeutics have long been awaited for this refractory condition. Transcription factor GATA2 is crucial in lymphatic development and maintenance, as GATA2 haploinsufficient disease often manifests as lymphedema. We recently demonstrated that Gata2 heterozygous deficient mice displayed delayed lymphatic recanalization upon lymph node resection. However, whether GATA2 contributes to lymphatic regeneration by functioning in the damaged lymph vessels' microenvironment rema ..read more
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Protein degraders - from thalidomide to new PROTACs
Oxford Academic - The Journal of Biochemistry
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2M ago
Abstract Recently, the development of protein degraders (protein-degrading compounds) has prominently progressed. There are two remarkable classes of protein degraders: proteolysis-targeting chimeras (PROTACs) and molecular glue degraders (MGDs). Almost 70 years have passed since thalidomide was initially developed as a sedative-hypnotic drug, which is currently recognized as one of the most well-known MGDs. During the last two decades, a myriad of PROTACs and MGDs have been developed, and the molecular mechanism of action (MOA) of thalidomide was basically elucidated, including identifyi ..read more
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Mitochondrial quality control via organelle and protein degradation
Oxford Academic - The Journal of Biochemistry
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2M ago
Abstract Mitochondria are essential eukaryotic organelles that produce ATP as well as synthesize various macromolecules. They also participate in signalling pathways such as the innate immune response and apoptosis. These diverse functions are performed by >1,000 different mitochondrial proteins. Although mitochondria are continuously exposed to potentially damaging conditions such as reactive oxygen species, proteases/peptidases localized in different mitochondrial subcompartments, termed mitoproteases, maintain mitochondrial quality and integrity. In addition to processing incoming precur ..read more
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Mitochondrial lipid dynamics regulated by MITOL-mediated ubiquitination
Oxford Academic - The Journal of Biochemistry
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4M ago
Abstract Mitochondria-endoplasmic reticulum (ER) contact sites in mammals provide platforms for various reactions, such as calcium signaling, lipid metabolism, organelle dynamics and autophagy. To fulfill these tasks, a number of proteins assemble at the contact sites including MITOL/MARCHF5, a critical mitochondrial ubiquitin ligase. How MITOL regulates mitochondrial function from the contact site, however, has been largely unresolved. Recently, a new role for MITOL in the active transport of phosphatidic acid from the ER to mitochondria was reported. In this commentary, we briefly summarize ..read more
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