Research team develops light-activated compounds to treat neuropathic pain
Phys.org - Biochemistry News
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4d ago
Light can be used to activate drugs in specific parts of the body through photopharmacology. This innovative approach involves modifying the chemical structure of a drug by adding a light-activated molecular switch, such as azobenzene. This allows the drug to be activated only when exposed to a specific color of light, rather than in the dark ..read more
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How to make an old antibiotic 100 times more potent
Phys.org - Biochemistry News
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4d ago
Nathaniel Martin, Professor of biological chemistry, wondered what would happen if you took an antibiotic that has been known for 70 years and tried to improve it with the latest tools of modern chemistry. Turns out it can become up to a hundred times more potent and prevent the growth of some drug-resistant bacteria. His team's research is published in PNAS ..read more
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Nanoplastics and 'forever chemicals' shown to disrupt molecular structures and functionality
Phys.org - Biochemistry News
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4d ago
Researchers at The University of Texas at El Paso have made significant inroads in understanding how nanoplastics and per- and polyfluoroalkyl substances (PFAS)—commonly known as forever chemicals—disrupt biomolecular structure and function. The work shows that the compounds can alter proteins found in human breast milk and infant formulas—potentially causing developmental issues downstream ..read more
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One-step synthesis of pharmaceutical building blocks: New method for anti-Michael reaction
Phys.org - Biochemistry News
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4d ago
In 1887, chemist Sir Arthur Michael reported a nucleophilic addition reaction to the β-position of α,β- unsaturated carbonyl compounds. These reactions, named Michael addition reactions, have been extensively studied to date. In contrast, the anti-Michael addition reaction, referring to the nucleophilic addition reaction to the α-position, has been difficult to achieve. This is due to the higher electrophilicity of the β-position compared to the α-position ..read more
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Researchers claim photoluminescent aerogel has a visible light reflectance of 104%
Phys.org - Biochemistry News
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4d ago
A team of chemists and materials scientists at Sichuan University, in China, has developed a photoluminescent aerogel with a visible light reflectance of 104%. In their study, published in the journal Science, the group created their aerogel from readily available biomass ..read more
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Photoenzymatic synthesis achieves efficient oxidation of fatty acids
Phys.org - Biochemistry News
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4d ago
A research team designed and built a photoenzymatic cascade by combining photochemical water oxidation/O2 reduction with P450 peroxygenase catalysis to achieve efficient visible-light-driven oxidation of a range of fatty acids (C12-C20), leading to production of α-alkenes and hydroxyl fatty acids ..read more
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First set of rational design principles for chaotropic membrane transporters
Phys.org - Biochemistry News
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4d ago
The challenge of internalizing impermeable molecules into cells persists in drug development, particularly concerning water-soluble bioactive compounds that cannot diffuse across the cell membrane. To overcome this problem, various artificial transporters, including polymers, lipids, and cationic penetrating peptides, have been engineered ..read more
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Novel compound offers improved defense against fentanyl overdoses
Phys.org - Biochemistry News
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4d ago
Scientists at the University of Florida have identified a novel compound aimed at improving the treatment of opioid overdoses, which claimed the lives of more than 81,000 Americans last year ..read more
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AI approach optimizes development of antibody drugs
Phys.org - Biochemistry News
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1w ago
Proteins have evolved to excel at everything from contracting muscles to digesting food to recognizing viruses. To engineer better proteins, including antibodies, scientists often iteratively mutate the amino acids—the units that are arranged in a sequence to make up proteins—in different positions until the resulting protein has an improved function, like eliciting a stronger immune response or capturing carbon dioxide from the atmosphere more efficiently ..read more
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A closer look at cell toxins: Researchers examine how radionuclides interact with kidney cells
Phys.org - Biochemistry News
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1w ago
When radionuclides enter our organism, whether by inhalation, ingestion, or through wounds, they pose a potential health risk. Many previous studies on radionuclide exposure have focused mainly on animal experiments. However, we have little data on toxicity at the cellular and molecular level ..read more
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