Leveraging Nanoparticle Technology for Paclitaxel Delivery in Pancreatic Cancer Patients
Let's Win - The Latest Pancreatic Cancer News
by susan
2d ago
Current chemotherapy regimens are often limited in the amount of drugs they can safely deliver to patients without becoming toxic or causing too many adverse side effects. A Korean company is hoping to expand the efficacy of existing cancer drugs like paclitaxel by packaging them in nanoparticles programmed to deliver the medication directly into pancreatic tumor cells. Onselex has developed what it calls an “intelligent cancer drug” able to home in on tumors and deeply penetrate tissues for extremely precise drug delivery. The company’s lead candidate, ONX-1006, encapsulates the drug paclit ..read more
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For Families at Risk, Remote Education May Be Key in Improving Genetic Testing Uptake
Let's Win - The Latest Pancreatic Cancer News
by susan
1w ago
Knowledge is power. And when it comes to a disease like pancreatic cancer, knowledge can translate into potentially better outcomes for not only the patient but their family members as well. One way to improve the odds for family members of pancreatic cancer patients is through genetic testing and counseling. Unfortunately, many families fall through the proverbial cracks. For some it’s due to distance from a large academic medical center where testing and counseling may be more readily available. For others it’s simply through lack of knowledge. A study called GENERATE found that remote lea ..read more
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Sometimes Things Get Worse Before They Get Better
Let's Win - The Latest Pancreatic Cancer News
by susan
1w ago
Matthew Rosenblum Symptoms of obstructive jaundice led to diagnosis Whipple attempted but metastatic disease found Two different types of chemotherapy to lead to second, successful Whipple Genetic testing confirmed BRCA2 mutation Maintenance with a PARP inhibitor In January 2021, my skin began to itch terribly—it felt like torture. I had moved to North Carolina from Michigan to help a friend with a business during the pandemic when I started having the itching and other mysterious symptoms—pale stools, dark urine, and yellowish eyes. All of these symptoms pointed to obstructive jaundice ..read more
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How to Eat with Pancreatic Cancer
Let's Win - The Latest Pancreatic Cancer News
by susan
2w ago
If you have pancreatic cancer, getting the nutrients you need can be a challenge. You might have a poor appetite and struggle to consume enough calories to maintain a healthy weight. You might even feel nauseous at the thought of eating—and for good reason. According to Maria Petzel, a registered dietitian at MD Anderson Cancer Center (Houston, Texas), the pancreas plays a key role in digestion. The fish-shaped organ not only produces and releases enzymes that break down proteins, fats, and carbohydrates, but it also regulates blood sugar levels, controlling the release of insulin and gluca ..read more
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Platform Trial Increases Efficiency in Studying Immunotherapy
Let's Win - The Latest Pancreatic Cancer News
by susan
2w ago
When people talk about the next big thing in cancer treatment, immunotherapy is bound to be at the top of the list. After years of limited success, researchers are now poised to hone in on those immunotherapy treatments that may hold the most benefit to select groups of patients. For example, scientists are combining cancer vaccines—one form of immunotherapy—with other forms of immunotherapy, to better kick-start the immune system into recognizing and killing cancer cells. A case in point is a study led by researchers from the Johns Hopkins Sidney Kimmel Cancer Center, the Bloomberg~Kim ..read more
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Cancer-Free and Running Strong
Let's Win - The Latest Pancreatic Cancer News
by susan
3w ago
Janice Canfield Jaundiced skin plus liver enzymes ten times higher than normal Whipple procedure and chemotherapy Life on the go Pancreatic cancer came into my life out of nowhere in September 2022, when I was 57 years old. I am a runner, nurse, avid traveler, and mother of four. I’m a nurse practitioner with a doctorate degree and have worked at Long Island Jewish Medical Center (New Hyde Park, New York) for many years. My family has no history of cancer. So I didn’t think much of it when my father noticed that my face was slightly yellow. I thought that maybe it was an end-of-summer tan ..read more
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Chemotherapy Plus Immunotherapy Trial Shows Promise
Let's Win - The Latest Pancreatic Cancer News
by susan
1M ago
Chemotherapy is a mainstay of pancreatic cancer treatment, regardless of a patient’s stage at diagnosis. When a tumor is surgically removable, chemotherapy may be administered before and/or after surgery. If a patient has metastatic disease, chemotherapy is part of the treatment plan to slow or stop the growth and spread of the cancer. The most common regimens are gemcitabine in combination with nab-paclitaxel, and FOLFIRINOX, a cocktail of four different drugs. Response rates hover around 25 percent for the gemcitabine/nab-paclitaxel regimen and about 35 percent for FOLFIRINOX. In the ..read more
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New FDA Approval Brings More Treatment Options in Metastatic Disease
Let's Win - The Latest Pancreatic Cancer News
by susan
1M ago
Diane A Reid; National Cancer Institute The U.S. Food and Drug Administration has approved irinotecan liposome (ONIVYDE) in combination with oxaliplatin, fluorouracil, and leucovorin, for the frontline treatment of metastatic pancreatic adenocarcinoma. The combo, dubbed NALIRIFOX, has been shown to improve overall survival for a disease that has far too few treatment options. This is the first new treatment approved for the first-line treatment of metastatic pancreatic cancer since the September 2013 approval of nab-paclitaxel (Abraxane) in combination with gemcitabine. This approval is base ..read more
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Nutrition Myths Debunked
Let's Win - The Latest Pancreatic Cancer News
by susan
1M ago
Oncology dietitians L.J. Amaral (left) and Jessica Harrison (right) When you’ve been diagnosed with pancreatic cancer—or any other type of cancer—it’s natural to explore every avenue to help boost your odds of a positive outcome. “When you have a cancer with a poor prognosis and limited options, you’re more willing to quite literally throw the kitchen sink at it to get either a better quality of life or more quantity of life,” says L.J. Amaral, M.S., R.D., certified nutrition coordinator at Cedars-Sinai Center for Integrated Research in Cancer and Lifestyle in Los Angeles, California. Unfort ..read more
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New Vaccine Harnesses Power Of the Lymph Nodes
Let's Win - The Latest Pancreatic Cancer News
by susan
1M ago
Recurrence of pancreatic cancer after surgery to remove the tumor is every patient’s fear, and rightly so. Even with chemotherapy after surgery, patients have a significant chance of the cancer coming back. This is because microscopic disease may lurk in the body, and it cannot be detected on scans. Undetected microscopic disease is the reason pancreatic cancer remains one of the most lethal of all malignancies. Although combination chemotherapy regimens and a drug class known as KRAS inhibitors are showing some promise for patients, immunotherapies, which have revolutionized treatment for s ..read more
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