Treatment with a q-switched laser targeting which of the following wavelengths, in nm, is most appropriate to remove a majority of the shown tattoo? A. 310 B. 532 C. 755 D. 1064 E. 1450 To find out the correct answer and read the explanation, click here. The post Laser Treatment – Friday Pop Quiz 4/19/2024 appeared first on Next Steps in Dermatology ..read more

ABSTRACT Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma, and extranodal involvement is seen in approximately 40% of cases. However, cases involving the skin and muscle are rare, and skin manifestations most commonly present as plaques, papules, small nodules, or ulcers. In this report, JDD authors Lauren E. Merz MD MSc, Christopher B. Hergott MD PhD, and Rebecca Zon MD discuss a case of a large exophytic mass involving skin, soft tissue, and muscle initially thought to be baso-squamous carcinoma subsequently identified as DLBCL and treated solely with che ..read more

Be excited about the new medications approved for use in pediatric patients, says Dr. A. Yasmine Kirkorian, chief of dermatology at Children’s National Hospital. Next Steps in Derm, in partnership with ODAC Dermatology, Aesthetic & Surgical Conference, interviewed Dr. Kirkorian about the use of JAK inhibitors in children. Should dermatology clinicians prescribe JAK inhibitors in this patient population? Learn how Dr. Kirkorian approaches the risks and benefits of JAK inhibitors, and why parent conversations are a must. Plus hear what Dr. Kirkorian thinks of the future of JAK inhibitors in ..read more

Verywell Health and several other media outlets are covering the issue of melanoma overdiagnosis in light of a recent study, which estimated more than 80,000 melanomas were overdiagnosed in white Americans in 2018 alone. Is melanoma overdiagnosis among white Americans a significant issue? What are the driving factors of overdiagnosis? What can dermatologists do better when diagnosing melanoma? For expert advice, I reached out to Valerie Harvey, MD, MPH, FAAD, a dermatologist in Newport News, Va. Dr. Harvey will speak on melanoma in skin of color at the upcoming Skin of Col ..read more

A 39-year-old woman presents for pruritic lesions of the bilateral lower extremities, as shown, without involvement elsewhere on the body. She denies joint pain, depressive symptoms, and difficulty with ambulation. She has previously tried treating the lesions with over-the-counter moisturizing cream without improvement. Which of the following is the most appropriate next step in the management of the patient? A. Total body narrowband UVB treatment 3 times per week B. Initiation of guselkumab injection C. Infusion of infliximab, followed by prednisone burst as needed D. Halobetasol 0.05% oin ..read more

Next Steps in Derm, in partnership with Pigmentary Disorders Exchange Symposium interviewed Dr. Susan C. Taylor, Bernett L. Johnson Endowed Professor, director of the Skin of Color Research Fellowship and vice chair for diversity, equity and inclusion in the dermatology department at the Perelman School of Medicine at the University of Pennsylvania. Watch as Dr. Taylor shares the causes of photodamage. (Spoiler alert: There’s more than UV radiation to blame.) Find out the impact of visible light and which skin tones are affected the most. Learn what photodamage looks like in darker skin tones ..read more

Generalized pustular psoriasis (GPP) is a rare, autoinflammatory condition, with acute, severe flares of diffuse sterile pustules and systemic symptoms that can be life-threatening. Historically, cyclosporine, methotrexate, retinoids, and biologics modulating the interleukin-17 (IL-17), IL-23, and tumor necrosis factor α pathways have been used off-label for management.1 Aberrant IL-36 signaling has been implicated in subsets of patients with GPP.2 We continue our series, Therapeutic Cheat Sheet, with a closer look at spesolimab, the only FDA-approved medication to date for treating generaliz ..read more

A laboratory’s recent claim that it detected the carcinogen benzene in certain acne treatments made news recently. The lab, Valisure, filed a petition with the FDA asking for a recall of the products involved. Chemists quoted in an Allure article said the issue is not one of contamination but potentially one of decomposition. The lab says it detected benzene when the benzoyl peroxide products were exposed to high temperatures. Dermatologist Dr. Caren Campbell requests more data, and dermatologist Dr. Marisa Garshick questions whether the lab conditions reflect real-life usage. From new produc ..read more

The neoplasm shown is made of cells that are most likely to contain which of the following substances? A. Histamine B. Antibodies C. Major basic protein D. Melanin E. Myeloperoxidases To find out the correct answer and read the explanation, click here.   The post Neoplasm – Friday Pop Quiz 4/5/2024 appeared first on Next Steps in Dermatology ..read more

Dr. Adam Friedman’s lecture at 2024 ODAC conference provided invaluable insights into the nuanced approach required when dealing with patients presenting with alopecia. Addressing the diverse array of alopecia types and their myriad presentations, Dr. Friedman emphasized the significance of a comprehensive clinical history and evaluation to formulate an effective treatment plan. By employing a case-based methodology, he skillfully demonstrated the importance of thorough patient assessment, highlighting key questions and examination techniques essential for accurate diagnosis and management. R ..read more