Combination Therapy of SSRIs and SGAs Is Optimal for Psychotic Depression
Psychiatry Advisor
by Addie
56m ago
The combination of a selective serotonin reuptake inhibitor (SSRI) and a second-generation antipsychotic (SGA) may be the most effective psychotic depression treatment approach, according to results from a systematic review and meta-analysis published in Lancet Psychiatry. Psychotic depression, characterized by hallucinations or delusions occurring during a major depressive episode, is associated with greater symptom severity and duration than non-psychotic depression. While current psychotic depression treatment guidelines recommend polytherapy with an antidepressant and antipsychotic, there ..read more
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Early Weight Gain Predicts Weight Restoration in ARFID Patients
Psychiatry Advisor
by Addie
56m ago
In avoidant/restrictive food intake disorder (ARFID), early weight gain is a reliable predictor for reaching 95% Expected Body Weight (EBW) at 20 weeks of treatment, according to study results published in The Journal of Eating Disorders. Given the broad age range of patients, these findings are relevant for both ARFID in adults and ARFID in children. Although weight is not a diagnostic criterion for ARFID, these patients are frequently underweight and malnourished due to restrictive or avoidant eating behaviors. Given that weight restoration is a primary treatment goal for many treatment cent ..read more
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Depression Tied to Higher Risk of CVD Events in Both Men and Women
Psychiatry Advisor
by Haymarket Media
56m ago
HealthDay News — There is a significant association between depression and subsequent cardiovascular disease (CVD) events in both men and women, according to a study published online March 12 in JACC: Asia. Keitaro Senoo, M.D., from Kyoto Prefectural University of Medicine in Japan, and colleagues used data from approximately 4.1 million individuals identified in the JMDC Claims Database (2005 to 2022) to investigate the association between depression and subsequent CVD events. The researchers found a significant association between depression and subsequent composite CVD events in both men an ..read more
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Low Emergency Nurse Staffing Tied to Adverse Events
Psychiatry Advisor
by Haymarket Media
5h ago
HealthDay News — Lower levels of nurse staffing in the emergency department are associated with adverse events, according to a review published online Feb. 1 in the International Journal of Nursing Studies. Jonathan Drennan, Ph.D., from the School of Nursing, Midwifery and Health Systems at University College Dublin, and colleagues conducted a systematic literature review to examine the relationship between nurse staffing, skill mix, and quality of care in the emergency department. Based on 16 included studies, the researchers found that poorer staffing levels in emergency departments are asso ..read more
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InfluenceCEF Study: In Influenza, Innate Immune Response May Cause Headaches
Psychiatry Advisor
by melissaalvarez
5h ago
In patients with influenza, headache appears to be linked to symptoms originating with the innate immune response, according to study results published in the Journal of Headache Pain. Patients with influenza often get a headache, but its cause is unknown. In the InfluenCEF study (ClinicalTrials.gov Identifier: NCT05704335), researchers in Spain sought to analyze demographic and clinical factors associated with headache during influenza infection and determine whether prognosis is different in influenza patients with vs without headache, as indicated by the need for hospital admission, sick le ..read more
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Early Tecovirimat Initiation May Be Beneficial for Patients With Severe Mpox
Psychiatry Advisor
by Aleta Terrill
5h ago
Early tecovirimat initiation for patients with severe mpox (previously monkeypox) infection may reduce time to symptom improvement, according to study results published in Open Forum Infectious Diseases. Researchers conducted a retrospective, cross-sectional, interview-based study to determine whether the timing of tecovirimat initiation affects outcomes among patients with mpox infection. Study data were captured from patients who were diagnosed with laboratory-confirmed mpox between May and October of 2022. Patients who did not receive tecovirimat were compared against those who initiated te ..read more
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Sensory, Motor Function Predicts Early Cognitive Impairment in Older Adults
Psychiatry Advisor
by Meahjabeen Hoque
1d ago
Older adults with impaired sensory and motor function are at greater odds of early cognitive impairment (ECI), according to study results published in Alzheimer’s and Dementia. However, improvements in multisensory, fine motor, and gross motor function reduced the odds of ECI, which may help guide future interventions aimed at reducing the incidence of ECI. Age-related sensory and motor impairments have previously been linked to a higher risk for mild cognitive impairment and Alzheimer Disease. Existing research indicates that these impairments are potential preclinical indicators of MCI, AD ..read more
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Bullying in Early Adolescence Impairs Interpersonal Trust, Worsens Mental Health
Psychiatry Advisor
by Meahjabeen Hoque
1d ago
Bullying in early adolescence is associated with a greater burden of internalizing, externalizing, and total mental health problems in late adolescence, according to study findings published in Nature Mental Health. These mental health problems were partially mediated by interpersonal distrust. The Social Safety Theory posits that socially threatening experiences reduce perceived social safety — characterized by distrust of others — and subsequently impair mental health over time. To test the validity of this theory, investigators evaluated how peer bullying in early adolescence affects mental ..read more
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FDA: Trivalent Influenza Vaccine Formulation Back for 2024-2025 Season
Psychiatry Advisor
by Diana Ernst, RPh
1d ago
Following a meeting of the Food and Drug Administration (FDA)’s Vaccines and Related Biological Products Advisory Committee, the Agency has decided that influenza vaccines manufactured for the 2024-2025 US influenza season will be trivalent. The decision was based on surveillance data indicating that there have been no confirmed detections of circulating B/Yamagata lineage viruses worldwide after March 2020. As it is no longer considered a public threat, the Committee voted in favor of excluding the B/Yamagata strain from quadrivalent seasonal influenza vaccines, reverting back to a trivalent ..read more
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Decreasing Opioid Use May Mean More Severe Pain for Patients With Cancer
Psychiatry Advisor
by Erin Clancy
1d ago
Recent declines in opioid prescribing may have resulted in inadequate pain control for patients with cancer, according to research published in JNCI Cancer Spectrum. Researchers found that decreasing opioid use between 2015 and 2021 coincided with patients with cancer experiencing more severe pain, but the same effect was not observed in patients without cancer. For this study, researchers analyzed data from 86,919 patients in the Veterans Affairs system in Palo Alto, California. Most patients were men (92.9%). About 10% of patients had cancer (n=9073). The most common cancers were prostate, c ..read more
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