Relationship between skin microvascular blood flow and capillary refill time in critically ill patients Critical Care volume 29, Article number: 57 (2025) Published: 04 February 2025 Background Capillary refill time (CRT) and skin blood flow (SBF) have been reported to be strong predictors of mortality in critically ill patients. However, the relationship ..read more

 Heterogeneity of treatment effect: the case for individualising oxygen therapy in critically ill patients Critical Care volume 29, Article number: 50 (2025)  Published: 28 January 2025 Abstract Oxygen therapy is ubiquitous in critical illness but oxygenation targets to guide therapy remain controversial despite several large randomised controlled ..read more

 Extremely early initiation of vasopressors might not decrease short-term mortality for adults with septic shock: a systematic review and meta-analysis Annals of Intensive Care volume 15, Article number: 18 (2025) Published: 27 January 2025 Background The optimal timing for initiating vasopressor therapy in patients with septic shock remains unclear. This ..read more

 Sex disparities in ICU care and outcomes after cardiac arrest: a Swiss nationwide analysis Critical Care volume 29, Article number: 42 (2025)  Published: 23 January 2025 Background Conflicting data exist regarding sex-specific outcomes after cardiac arrest. This study investigates sex disparities in the provision of critical care and outcomes of ..read more

 The association between pain, analgesia, and delirium among critically ill adults: a systematic review and meta-analysis Intensive Care Medicine Published: 22 January 2025 Purpose We performed a systematic review with meta-analysis examining the relationship between pain or pain medications and delirium occurence, duration, and severity. Methods We searched MEDLINE, EMBASE, CINAHL and ..read more

 The role of phospholipid transfer protein in sepsis-associated acute kidney injury Critical Care volume 29, Article number: 33 (2025)  Published: 20 January 2025 Background Phospholipid transfer protein (PLTP), a glycoprotein widely expressed in the body, is primarily involved in plasma lipoprotein metabolism. Previous research has demonstrated that ..read more

 Impact of frailty and older age on weaning from invasive ventilation: a secondary analysis of the WEAN SAFE study Annals of Intensive Care volume 15, Article number: 13 (2025) Published: 20 January 2025 Objective To understand the impact of both frailty and chronologic age on outcomes of weaning from invasive mechanical ventilation (MV). Methods The study ..read more

 Cardiovascular effects of lactate in healthy adults Critical Care volume 29, Article number: 30 (2025)  Published: 17 January 2025 Background Low-volume hypertonic solutions, such as half-molar lactate (LAC), may be a potential treatment used for fluid resuscitation. This study aimed to evaluate the underlying cardiovascular effects and mechanisms of ..read more

 Procedural sedative effect of remimazolam in ICU patients on invasive mechanical ventilation: a randomised, prospective study Annals of Intensive Care volume 15, Article number: 8 (2025) Published: 14 January 2025 Background Invasive procedures and environmental factors in the intensive care unit (ICU) may cause anxiety and discomfort in patients, who often ..read more

 Creatinine production rate is an integrative indicator to monitor muscle status in critically ill patients Critical Care volume 29, Article number: 23 (2025) Published: 14 January 2025 Background Both quantitative and qualitative aspects of muscle status significantly impact clinical outcomes in critically ill patients. Comprehensive monitoring of baseline ..read more