GFAP and NfL Are Robust Dementia Markers When Considering Hypercholesterolemia
Neurology Advisor
by Emily Estrada
6h ago
Serum glial fibrillary acidic protein (GFAP) and neurofilament light chain (NfL) may be more effective dementia risk predictors than phosphorylated tau181 (p-tau181), according to a study published in Alzheimer’s & Dementia. There are blood biomarkers for dementia risk that have been established and high cholesterol has been considered to be a modifiable risk factor for dementia risk. For the study, researchers from centers in Germany and the United Kingdom evaluated whether blood biomarkers of dementia differ in the setting of hypercholesterolemia. Researchers sourced data for this analys ..read more
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Mild Infection Tied to Better Long COVID Symptom Resolve in Younger Patients
Neurology Advisor
by Emily Estrada
6h ago
Unvaccinated individuals who had mild COVID-19 were at increased risk for some sequelae outcomes, such as anosmia and dysgeusia, respiratory conditions, and concentration and memory conditions. However, most symptoms were found to be resolved within a year of diagnosis, especially for younger patients. These are the findings of a nationwide, retrospective cohort study published in BMJ. Acute SARS-CoV-2 infections have been associated with multiple long-term sequelae conditions, however, to date it remains unclear whether mild COVID-19 may also be associated with risk for long-term sequelae. Re ..read more
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IV Ketamine in Treatment-Resistant Bipolar Depression Shows Real-World Efficacy
Neurology Advisor
by Aleta Terrill
6h ago
Repeated IV ketamine infusions were associated with real-world improved psychosocial functional impairments as well as improved depressive and anxiety symptoms among adults with treatment-resistant bipolar disorder, according to study findings published in Bipolar Disorders. Researchers sought to characterize real-world efficacy of repeated ketamine infusions for treatment-resistant bipolar depression assessing symptoms of depression, anxiety, suicidality, and functioning. They conducted an observational study (ClinicalTrials.gov Identifier: NCT04209296) in a community clinic in Mississauga, O ..read more
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COVID-19 With Opioid, Cocaine Use Increases Endocarditis Risk
Neurology Advisor
by Aleta Terrill
6h ago
Individuals with opioid or cocaine use disorders who are infected with COVID-19 were at increased risk for endocarditis, according to results of a study published in Molecular Psychiatry. Investigators from Case Western Reserve University School of Medicine and the National Institutes of Health sourced data for this study from the TriNetX Analytics Network platform. Electronic health records from 77 health care organizations located in all 50 states in the United States were evaluated for a risk for endocarditis among patients with opioid use disorder (OUD) or cocaine use disorder (CocaineUD ..read more
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Childhood Maltreatment Is Partial Causal Factor for Later Mental Health Problems
Neurology Advisor
by Haymarket Media
6h ago
HealthDay News — Experiencing abuse or neglect as a child can cause multiple mental health problems, according to a review published online Jan. 11 in The American Journal of Psychiatry. Jessie R. Baldwin, Ph.D., from University College London, and colleagues conducted a systematic review and meta-analysis to examine the relationship between childhood maltreatment and mental health problems. Based on 34 quasi-experimental studies (54,646 independent participants), the researchers found that childhood maltreatment was moderately associated with mental health problems (Cohen’s d = 0.56). In an a ..read more
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Nearly Half of People With Dementia Experience a Fall Annually
Neurology Advisor
by Haymarket Media
6h ago
HealthDay News — Nearly half of people with dementia experienced a fall in 2016, according to a study published online Jan. 12 in Alzheimer’s & Dementia. Safiyyah M. Okoye, Ph.D., from the Johns Hopkins University School of Nursing in Baltimore, and colleagues used data from the 2015 and 2016 National Health and Aging Trends Study to identify fall-risk factors among community-living older adults aged 65 years and older with and without dementia (5,581 individuals). The researchers found that fall rates were higher among people living with dementia versus those without dementia (45.5 versus ..read more
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Negative Fecal Tests Tied to Low Risk for Advanced Colorectal Cancer
Neurology Advisor
by Haymarket Media
6h ago
HealthDay News — There was a low risk for advanced neoplasia after multiple rounds of negative fecal immunochemical tests (FIT) in people undergoing surveillance colonoscopy, according to a study published online Jan. 4 in Clinical Gastroenterology and Hepatology. Molla M. Wassie, Ph.D., from Flinders University in Bedford Park, Australia, and colleagues examined the relationship between number of rounds of negative FIT and the risk for advanced neoplasia in individuals undergoing surveillance colonoscopy. The analysis included 3,369 individuals (aged 50 to 74 years) who had completed a two-sa ..read more
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Persistent Gaps Exist in Continuity of Medication Use for Adults With Diabetes
Neurology Advisor
by Haymarket Media
6h ago
HealthDay News — A considerable proportion of adults with diabetes do not maintain continuity of use of glucose, blood pressure, or lipid medications, according to a study published online Jan. 30 in JAMA Network Open. Puneet Kaur Chehal, Ph.D., from the Rollins School of Public Health at Emory University in Atlanta, and colleagues examined trends in longitudinal use of glucose, blood pressure, and lipid medications among adults with diabetes in the Medical Expenditure Panel Survey, using data for the 2005 to 2006 and 2018 to 2019 panels. The analytical sample included 15,237 participants with ..read more
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Adults With Chronic Pain Replace Opioids With Medical Cannabis for Pain Relief
Neurology Advisor
by Emily Estrada
1d ago
Among adults with chronic pain who live in US states with medical cannabis programs, 3 in 10 report using medical cannabis for pain management. More than half of these adults report a decreased use of other pain medications including prescription opioids. These are the findings of a study published in JAMA Network Open. Given the recent opioid crisis caused by increasing rates of death due to opioid overdose, questions have arisen regarding use of medical cannabis as an effective alternative for managing chronic pain unrelated to cancer. To answer this question, researchers conducted a cross-s ..read more
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FDA Greenlights Ibuprofen Oral Suspension Compounding to Help With Hospital Supply
Neurology Advisor
by Diana Ernst, RPh
1d ago
In an effort to increase the supply of ibuprofen oral suspension products in hospitals and health systems, the Food and Drug Administration (FDA) has issued guidance on the preparation of compounded versions of the analgesic/antipyretic medication. Compounded products are not approved by the FDA as they have not undergone review for safety, effectiveness, or quality. Increased demand for ibuprofen oral suspension products due to a surge in 3 circulating viruses (COVID-19, respiratory syncytial virus, and influenza) has prompted the Agency to issue recommendations for the compounding of ibuprof ..read more
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