In recent years, anti-cancer and stem cell differentiation properties have been reported for some molybdenum derivatives such as molybdenum disulfide (MoS2). Diabetes mellitus as a chronic metabolic disorder has symptoms such as insufficient insulin secretion or insulin dysfunction due to β cell destruction. Each of the current diabetes treatment methods has limitations. In the present research the effects of MoS2–PEG on survival rate, expression of genes involved in glucose metabolism, and insulin secretion in diabetic RIN-5F β cell was studied. Synthesized MoS2-PEG nanosheets was used for po ..read more

G. lucidum mushroom has been recorded in conventional medicine for more than 2000 years due to has several bioactive compounds including triterpenoids (GLTs). This study aimed to extract and detect of the triterpenoids and biological synthesis of Zinc oxide nanoparticles by using the aqueous extract of this mushroom, then evaluate their antifungal activity against four dermatophytes. From the 1000 g of G. lucidum dried fruiting bodies powder which were used in this study, 16.1 g GLTs was extracted. HPLC was used to analyses GLTs and detection of Ganoderic Acid by using (Ganoderic Acid A) as a ..read more

Biothiols are the main part of different proteins and matabolites which have tremendous impact on the neutralization of oxidative stress in the cell and stability of the intracellular environment. Metabolite perturbation of these compounds can be indicative of many serious diseases such as weight loss, liver damage, cardiovascular diseases and Alzheimer’s. Thus, tremendous researches have been devoted on the detection of thiols via biossensors and nanosensors using electrochemical methods. Higher sensitivity, selectivity, catalytic activity, conductivity, and biocompatibility are the ..read more

The synthesis of novel nanomaterials stands as a significant focus of scientific inquiry in nanotechnology. This study synthesized Fe-Ag-V ternary oxide nanoparticles sourced from Ganoderma lucidum extract. The eco-friendly synthesis process involves several steps, including dissolving PVP polymer in Ganoderma lucidum extract, introducing metal salts, Gum Arabic, maturation, gel formation, drying, and culminating in calcination. The resulting nanoparticles, comprising iron, silver, and vanadium, exhibit distinct structural and compositional features. Characterization methods like Dynamic Light ..read more

Many stem cells are located in different areas of the central nervous system. including suprachiasmatic nucleus (SCN). This research investigate the NSCs transplantation on sleep wake cycle in suprachiasmatic nucleus lesion of rat. Apigenin coated gold nanoparticles has been synthesized. NSCs were cultured in DMEM F12 enriched with apigenin coated gold nanoparticles. Thirty adult male Wistar rats weighing between 220-250 gr, were classified into three groups (Lesion, experimental, Control. Subventricular zone (SVZ) of newborn rat brains were applied for NSCs seperation. The animals received Su ..read more

Objectives: This study evaluated the impact of Silver nanoparticles (Ag NPs) and Salvia officinalis (Sage) hydroalcoholic extract on the expression level of vascular endothelial growth factor (VEGF) and matrix metalloproteinase 2 (MMP2) genes involved in wound healing. Material and Methods: An excision wound was induced on the back of the 48 adult male mice. Wound treatments were done with Ag NPs and sage extract in separate animal groups for 14 days. two weeks after treatment, the wound skin tissue was removed and gene expression analysis was done by real-time polymerase chain reaction. Resul ..read more

Vitamin C (Vit-C) and lemon essential oil have several notably benefits for human skin physiology such as stimulating the biosynthesis of collagen, reduce acne and dark spot. But, they poorly bypass the epidermis stratum corneum barrier. Also, lemon essential oil has high vapor pressure. To address these challenges, our aim was preparing and size optimizing a lipophilic version of Vit-C (Ascorbyl tetraisopalmitate) and lemon essential oil by encapsulation of them inside of nanoemulsion droplets (used as oil phase of nanoemulsion), for improving skin diffusion and delivery across the stratum co ..read more

Cancers and bacterial infections are significant global public health challenges and economic issues. Nanostructures containing essential oils have been considered a suitable alternative as therapeutic agents. In this study, the chemical composition of Matricaria chamomilla essential oil (EO) as herbal medicine was investigated using GC-MS analysis. β-hymacalene (23%), limonene (10%), azonol (9%), and α-farnesene (9%) were identified as major compounds. Different tween 20 and tween 80 concentrations were screened to prepare an optimum nanoemulsion containing the EO. It showed a circular shape ..read more

The field of bioceramics has emerged as a critical component in various medical and dental applications, with calcium phosphate (CaP) materials like tricalcium phosphate (TCP) gaining significant attention. CaP bioceramics are valued for their exceptional biocompatibility, osteoconductivity, and ability to promote new bone formation, making them invaluable in the optimization of dental implant integration and performance. Through the use of a feedforward artificial neural network (FFANN), the researchers were able to predict the changes in dental ceramics, biocompatibility, and tissue reaction ..read more

In this study, we prepared Epirubicin-loaded magnetic solid lipid nanoparticles for intravenous drug dosing. Magnetic lipid carriers were fabricated using a hot microemulsion approach using stearic acid and Compritol ATO 888 as a core of particles. Prepared nanoparticles are characterized using transtition electon microscopy, photon correlation spectroscopy, Fourier transforms infrared spectroscopy, and vibrating sample magnetometer. The size of nanoparticles was about 130 nm after drug loading. Also, entrapment efficiency, drug loading, in vitro drug release, and release kinetic were investig ..read more