One of the most potentially hazardous diseases, prostate cancer has a high morbidity and mortality rate. Polymeric matrix drug-eluting implants have become widely employed, and modeling their behavior is becoming more and more prominent. It is always difficult to achieve effective drug delivery and release of it into specific tumor sites. One of the most significant purposes of this investigation, is the enhancement of the anticancer effects of prostate cancer treatment by co-delivering anticancer multi-drugs with PU-PCL films. The films were recognized utilizing SEM  (scanning electr ..read more

The green synthesis of nanoparticles (NPs) can be achieved through the use of eco-friendly and readily available herbal extracts. In this particular study, the aqueous root extract of Biebersteinia multifidi (B. multifidi) plant was used to prepare pure zinc oxide (ZnO) nanoparticles as well as Ag-doped ZnO NPs (Ag/ZnO NPs) at concentrations of 1%, 5%, and 10%. The physicochemical features of NPs were characterized by field emission scanning electron microscopy (FESEM) and energy-dispersive X-ray spectroscopy (EDX), powder X-ray diffraction (PXRD), and UV-Vis spectrophotometer techniques. The ..read more

Populations suffer from chronic disorders especially hypothyroidism. To decrease thyroid-stimulating hormone (TSH) and medicate hypothyroidism in patients were diagnosed with thyroid cancer and nodular thyroid disease, levothyroxine is utilized clinically.  Applications of metal-organic frameworks (MOFs) in various fields of medicine have attracted much attention. Loading levothyroxine onto the nanostructured Cu(II)-MOFs, Cu(II)-BTC, as well as subsequent drug release behavior were studied. Nanostructured Cu(II)-BTC was used to load and release the drug levothyroxine. The obtained res ..read more

Objective(s): Exosomes are nanovesicular vehicles capable of transporting different cargoes. Based on their characteristics, exosomes are proposed as a class of vehicles for targeted delivery of therapeutics. We aimed to establish a HEK293T stable cell line capable of secreting GRP78-specific scFv-targeted exosomes.Methods: The pLEX-LAMP2b-GRP78 construct was developed by enzymatic replacement of DARPin in pLEX-LAMP2b-DARPin with a GRP78-specific scFv. pLEX-LAMP2b-GRP78 (or TurboGFP as control), psPAX2, and pMD2.G plasmids were co-transfected into HEK293T cells, and produced lentiviruses were ..read more

Objective(s): In this work, silver nanoparticles (Ag NPs) were synthesized by green tea plant extract as an easy, cost-effective, environmentally friendly, and reliable synthesis. The silver nanocomposite with different amounts of starch (0.5, 1, 1.5 g) were prepared. Then, the methylene blue (MB) dye degradation and the antibacterial activity of the nanocomposite were evaluated as an environmental challenge.Methods: The samples were characterized using scanning electron microscope (SEM) for observation size and morphology, energy dispersive X-ray analysis (EDX) for determination elemental ana ..read more

The research investigated the performances of pristine and Si-doped fullerenes (C20 and SiC19) as an adsorbent and sensor for the removal and detection of methyl paraben (MP) using density functional theory computations. The results indicated that MP interaction with C20 is experimentally impossible, endothermic, and non-spontaneous, suggesting that C20 is not an effective adsorbent for the removal of MP. On the other hand, MP adsorption on the surface of SiC19 is experimentally feasible, exothermic, spontaneous, and thermodynamically reversible, indicating that SiC19 could be a potential adso ..read more

Objective(s): Klebsiella pneumoniae is a significant opportunistic bacterial pathogen, responsible for over 70% of human infections. The development of carbapenem resistance is considered a major risk to public health.Methods: Cultivation of Klebsiella pneumonia isolates (100 samples) for phenotypic identification. Drug sensitivity was evaluated by disc diffusion method, and carbapenemase-producing isolates were identified by the mCIM and eCIM methods.  Lactobacillus acidophilus and Bifidobacterium bifidum were cultured and carbon dots were synthesized by hydrothermal method. The phys ..read more

This study aimed to enhance the effectiveness and water solubility of Minoxidil (MXD) by producing its nanocrystal structure, which improves its vasodilator properties and promotes hair growth. In the current study, the hair growth-stimulating activity of the MXD nanoparticles (MXD-NPs) was compared with the hydroethanolic rosemary (RSY) extract on the C57BL/6 mice. The MXD-NPs were produced through a bead mill and ultrasonic process and characterized using various techniques. The cytotoxicity of MXD-NPs was studied on human dermal fibroblasts, and their hair growth-stimulating activity was an ..read more

Nanotechnology is applied in many scientific domains because it provides a variety of practical answers to scientific and medical problems. This systematic literature review using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) method to analyze nanocomposite hydrogels (NCHGs) in dentistry. Based on the results of a literature review study on 40 articles, NCHGs have the potential for antibacterial agents, tissue engineering, drug delivery systems, dental materials, etc. The present review aims to provide a depth analysis of NCHGs, impart on the recent advancemen ..read more

Objective(s): The world of dentistry is constantly evolving, and with the advent of 3D printing technology, the possibilities are endless. However, little is known about the effects of adding ZrO2 NPs to the denture base resin of 3D additive manufacturing technique.Aim of this study is to evaluate the behavior of resin which is used to 3D printing of denture base with the addition of ZrO2 NPs on denture adaptation property and diametral compression strength.Methods: 60 samples were printed, 30 disks for diametral compressive test and 30 denture base for denture adaptation test. Three groups pe ..read more