Objective(S): Magnetic iron oxide nanoparticles are remarkably potent drug nanocarriers due to their intrinsic capacity for elevated drug loading, biocompatibility, stability. This study focused on the development of iron oxide (Fe3O4) nanoparticles by the green synthesis method and PEGylated method, utilizing Eriobotrya japonica leaf extract. Methods: The physicochemical parameters were determined using Dynamic Light Scattering (DLS), Field Emission Scanning Electron Microscopy (FESEM), Transmission Electron Microscopy (TEM), Fourier Transform Infrared (FTIR), X-ray Diffraction (XRD), and cyt ..read more

The study examined the effectiveness of C8B6N6 nanoclusters in acting as both an adsorbent and sensor for removing and detecting sulfamethoxazole (SMZ) using density functional theory computations. The findings indicated that the interaction between SMZ and C8B6N6 is feasible, exothermic, and spontaneous, highlighting the potential of C8B6N6 as an efficient adsorbent for SMZ removal. The research also investigated the impact of water as the solvent and varying temperature on the thermodynamic parameters, revealing no significant influence on the interactions. Additionally, the Frontier Molecul ..read more

Background: Pediatric acute lymphoblastic leukemia (pALL) is the most prevalent neoplasm in children. pALL diagnostic process is invasive, and children need to be anesthetized for bone marrow aspiration. Exosomes are nanoparticles that reflect the status of parental cells. Given the elevated levels of exosomes in the peripheral blood of pALL patients, they can be readily extracted from blood plasma. The aim of this study was to compare the reliability of two different techniques of exosome purification in order to select the best method for clinical use in pALL. Methods: Exosomes were isolated ..read more

Objective: MgO nanoparticles (MgO NPs) could be effective on anxiety-related behaviors in animal models but their exact mechanism of action compared to their conventional form (C MgO) is unclear. This study investigated and compared the effect of MgO NPs and C MgO on anxiety-related behavior in the sleep-deprived (SD) rats and biochemical parameters changes in the serum. Methods: In this experimental study male Wistar rats (180-220g) were divided into groups of control, 24, 48, and 72 h of SD induction, and 72 h SD+ MgO NPs or C MgO (1, 5, and 10 mg/kg). Components were injected a day after SD ..read more

One of the most potentially hazardous diseases, prostate cancer has a high morbidity and mortality rate. Polymeric matrix drug-eluting implants have become widely employed, and modeling their behavior is becoming more and more prominent. It is always difficult to achieve effective drug delivery and release of it into specific tumor sites. One of the most significant purposes of this investigation, is the enhancement of the anticancer effects of prostate cancer treatment by co-delivering anticancer multi-drugs with PU-PCL films. The films were recognized utilizing SEM  (scanning electr ..read more

The green synthesis of nanoparticles (NPs) can be achieved through the use of eco-friendly and readily available herbal extracts. In this particular study, the aqueous root extract of Biebersteinia multifidi (B. multifidi) plant was used to prepare pure zinc oxide (ZnO) nanoparticles as well as Ag-doped ZnO NPs (Ag/ZnO NPs) at concentrations of 1%, 5%, and 10%. The physicochemical features of NPs were characterized by field emission scanning electron microscopy (FESEM) and energy-dispersive X-ray spectroscopy (EDX), powder X-ray diffraction (PXRD), and UV-Vis spectrophotometer techniques. The ..read more

Populations suffer from chronic disorders especially hypothyroidism. To decrease thyroid-stimulating hormone (TSH) and medicate hypothyroidism in patients were diagnosed with thyroid cancer and nodular thyroid disease, levothyroxine is utilized clinically.  Applications of metal-organic frameworks (MOFs) in various fields of medicine have attracted much attention. Loading levothyroxine onto the nanostructured Cu(II)-MOFs, Cu(II)-BTC, as well as subsequent drug release behavior were studied. Nanostructured Cu(II)-BTC was used to load and release the drug levothyroxine. The obtained res ..read more

Objective(s): Exosomes are nanovesicular vehicles capable of transporting different cargoes. Based on their characteristics, exosomes are proposed as a class of vehicles for targeted delivery of therapeutics. We aimed to establish a HEK293T stable cell line capable of secreting GRP78-specific scFv-targeted exosomes.Methods: The pLEX-LAMP2b-GRP78 construct was developed by enzymatic replacement of DARPin in pLEX-LAMP2b-DARPin with a GRP78-specific scFv. pLEX-LAMP2b-GRP78 (or TurboGFP as control), psPAX2, and pMD2.G plasmids were co-transfected into HEK293T cells, and produced lentiviruses were ..read more

Objective(s): In this work, silver nanoparticles (Ag NPs) were synthesized by green tea plant extract as an easy, cost-effective, environmentally friendly, and reliable synthesis. The silver nanocomposite with different amounts of starch (0.5, 1, 1.5 g) were prepared. Then, the methylene blue (MB) dye degradation and the antibacterial activity of the nanocomposite were evaluated as an environmental challenge.Methods: The samples were characterized using scanning electron microscope (SEM) for observation size and morphology, energy dispersive X-ray analysis (EDX) for determination elemental ana ..read more

The research investigated the performances of pristine and Si-doped fullerenes (C20 and SiC19) as an adsorbent and sensor for the removal and detection of methyl paraben (MP) using density functional theory computations. The results indicated that MP interaction with C20 is experimentally impossible, endothermic, and non-spontaneous, suggesting that C20 is not an effective adsorbent for the removal of MP. On the other hand, MP adsorption on the surface of SiC19 is experimentally feasible, exothermic, spontaneous, and thermodynamically reversible, indicating that SiC19 could be a potential adso ..read more