Uptake of intrauterine devices (IUDs) in the adolescent population may be limited by anxiety and pain anticipated during the insertion procedure. Our institution offers conscious sedation for IUD insertion to mitigate this concern. The objective of this study was to identify characteristics and outcomes of teens choosing between two types of conscious sedation for insertion of a levonorgestrel IUD ..read more

Vulvodynia is vulvar pain of at least 3 months duration, without an identifiable cause. In adults, vulvodynia is associated with urogenital symptoms, immunological issues, and other chronic pain conditions. In children and adolescents, only one published case series described an association with urinary symptoms. Associations with other conditions and immunologic issues remain unknown. This study aims to evaluate the association of urogenital symptoms, immunological issues and chronic pain disorders with vulvodynia in children and adolescents using a large research network database (TriNetX ..read more

Adolescents are disproportionately affected by STIs and account for approximately half of new STIs annually. Increasing access to testing and treatment could reduce STI transmission rates. Thus, this study sought to understand adolescents’ perspective of home-based STI testing to improve accessibility and uptake ..read more

Chemotherapy-induced ovarian failure is one of the severe challenges that female cancer survivors face in the reproductive age. Oocyte and ovarian tissue cryopreservation are fertility preservation methods with growing evidence yet remain an expensive option for many. Alternative fertility-preserving agents should be tailored according to the underlying mechanism of cytotoxic treatment the survivor is exposed to. Cyclophosphamide is one of the most common cytotoxic agents, with a wide spectrum of indications from childhood cancers to autoimmune diseases ..read more

In women who undergo unilateral oophorectomy (UO), some studies have shown that spontaneous pregnancy rates are similar to those who still have both ovaries intact. Furthermore, women who underwent UO entered menopause approximately 1 year earlier than those who have both ovaries, suggesting a compensatory mechanism. Since these effects are lower than what would be expected from the loss of half of the ovarian reserve, the aim of this study was to investigate possible compensatory mechanisms of follicle protection in the retained ovary after UO in mouse models ..read more

Hair-thread tourniquet syndrome (HTTS) is a rare, potentially dangerous disorder typically involving hair or synthetic fibers wrapped around fingers or toes of infants and children, but can also involve the genitals It is a medical emergency that can result in appendage amputation, it is imperative for PAG, ER physicians, and pediatricians to rapidly identify and consider this as a differential diagnosis. The goal of this case study is to bring awareness to the clinical presentation of HTTS of the labia, treatment, and review current literature for best management practices ..read more

Adolescent pregnancy is defined as pregnancy before the age of 20 and is the leading cause of mortality in girls ages 15 to 19 worldwide. Adolescent pregnancies are associated with increased maternal, obstetric, and neonatal risks, however data is limited. Our objective was to compare the risk of adverse obstetrical outcomes in teenage pregnancies to adult pregnancies ..read more

For the patient with an anorectal malformation (ARM), it is an immediate trigger to perform a VACTERL workup because of the well-known association of other organ anomalies. However, sometimes forgotten in the female patient, is to assess for gynecologic abnormalities. It is well established that 2.2-52.6% of patients with ARMs may have a Mullerian anomaly and VACTERL does increase this risk ..read more

Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome, affecting 1 in 5000 females, is a mullerian anomaly characterized by uterovaginal malformation with the diagnosis typically following investigation of primary amenorrhea (1). Vater Syndrome (VACTERL) is a broad term describing a constellation of congenital abnormalities with an estimated incidence of 1 in 10,000 to 40,000 births (2). Here we present a case of MRKH with co-existing VACTERL to highlight commonalities in presentation with the goal to improve knowledge, early identification, and opportunities for research ..read more

Prader-Willi Syndrome (PWS) is a genetic imprinting syndrome associated with high rates of endocrinopathies such as growth hormone deficiency, thyroid dysfunction, and primary and central hypogonadism. True puberty is absent, delayed, or incomplete in many individuals with PWS, although premature adrenarche is common. The literature on hypogonadism in females with PWS is sparse and no guidelines exist for hypogonadism treatment. We aimed to characterize bleeding patterns and current practices of hormone replacement therapy (HRT) in adolescent and young adult PWS females at a single center in o ..read more