Gyratory Seizures in Hypothalamic Hamartoma
Journal of Epilepsy Research
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2w ago
Gyratory seizures (GS) are a rare seizure type characterized by body rotation of ≥180° around its vertical axis. While GS have been documented in various epileptic syndromes, their occurrence in association with hypothalamic hamartomas (HH) has not been reported previously. This case report introduces the first documented instance of GS in a patient with a HH, a non-neoplastic tumor originating from the tuber cinereum. The patient, a 25-year-old female, with a history of recurrent seizures since childhood, initially presented with gelastic seizures, marked by inappropriate laughter, and subseq ..read more
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Laughter-Induced Seizures: A Rare Type of Reflex Epilepsy
Journal of Epilepsy Research
by
2w ago
This research explores the rare occurrence of laughter-induced seizures, a form of reflex epilepsy documented in only one previous case in the literature. The patient, free from prior medical or neuropsychiatric history, exhibited seizures triggered solely by laughter. Electroencephalography and neuroimaging revealed normal results. Despite declining medical therapy, lifestyle modifications enabled seizure management. The study emphasizes the dearth of data on laughter-induced seizures, prompting the consideration of multimodal strategies for treatment. Further research is imperative to unveil ..read more
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On Seizures and Knives: Perampanel-Induced Psychosis: A Case Report and Literature Review
Journal of Epilepsy Research
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2w ago
Managing epilepsy in the context of intellectual disability can be complicated as this population is known to have higher rates of drug resistance and sensitivity to side effects of antiseizure medications (ASMs). Perampanel is a novel ASM recently approved as an adjunctive treatment for drug resistant focal seizures. It carries a black-box warning for serious psychiatric and behavioral adverse reactions of aggression, irritability, et cetera. However, psychosis is a seldom reported side effect of perampanel. We herein describe a case of a 15-year-old girl with moderate intellectual disability ..read more
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Unmasking a Hidden Culprit: Neurocysticercosis, an Overlooked Cause of Acquired Epilepsy
Journal of Epilepsy Research
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2w ago
Neurocysticercosis (NCC) is a common parasitic brain infestation caused by the ingestion of Taenia solium eggs, predominantly in developing countries. In this report, we presented the case of a 44-year-old woman who exhibited stroke symptoms and had a decade-long history of recurrent headaches and epilepsy. At presentation, a non-contrast computed tomography scan of the brain was performed and revealed hypodense oval lesions and calcified cysts in both cerebral hemispheres, strongly indicative of NCC. The patient responded positively to treatment with dexamethasone, albendazole, and carbamazep ..read more
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Pentylenetetrazole-Induced Seizures in Wistar Male Albino Rats with Reference to Glutamate ...
Journal of Epilepsy Research
by
2w ago
Background and Purpose: Epilepsy is a common and heterogenous neurological disorder characterized by recurrent spontaneous seizures. Animal models like rats play a crucial role in finding of mechanism of epilepsy in different brain regions. i.e., cerebral cortex, cerebellum, hippocampus, and pons medulla. Glutamate is an important excitatory neurotransmitter in the central nervous system and also glutamate plays a vital role in neuronal development and memory. The process of neuronal death evolved by glutamate receptor activation, has been hypothesized in both acute and chronic degenerative di ..read more
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Medication Reconciliation Errors on Discharge for Epilepsy Monitoring Unit Patients
Journal of Epilepsy Research
by
2w ago
Background and Purpose: Medication errors are common in the inpatient setting. Epilepsy patients who miss doses of their antiseizure medications are at risk for breakthrough seizures and subsequent complications. The purpose of this study was to quantify and characterize anti-seizure medications reconciliation errors on discharge from the epilepsy monitoring unit (EMU). Methods: Consecutive admissions to an academic medical center EMU were retrospectively reviewed. Medication reconciliation errors on discharge, including drug errors, dosing errors, and dose timing errors, were recorded. Associ ..read more
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Additive Anticonvulsive Effects of Sumatriptan and Morphine on Pentylenetetrazole-Induced ...
Journal of Epilepsy Research
by
2w ago
Background and Purpose: Sumatriptan protects the brain from damage and enhance the anti-seizure effect of morphine. There is evidence that nitric oxide (NO) may mediate these effects of both drugs. In the present study, we investigated the effects of sumatriptan (0.1-20 mg/kg, intraperitoneal [i.p.]) and morphine (0.1-20 mg/kg, i.p.) alone or in combination on seizure thresholds in an in vivo model of seizure in mice. Using various NO synthase inhibitors as well as the NO precursor, we assessed possible involvement of NO signaling in these effects. Methods: Clonic seizures were induced in male ..read more
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Modified Atkins Diet in Adolescents and Adults with Drug Resistant Epilepsy: A Systematic ...
Journal of Epilepsy Research
by
2w ago
Epilepsy is one of the common neurological diseases which affects 65-70 million people worldwide. Modified Atkins diet (MAD) as a therapy is used as one of the treatments to reduce the seizures occurrence in epileptic patients. The purpose of this purpose is to review all evidence regarding the efficacy of the MAD from randomized controlled trials (RCTs) in adolescents and adults with drug resistant epilepsy (DRE). The total of three databases were searched (PubMed, Embase, and Cochrane Library) till 31 January 2023. Only RCTs with MAD as a one of the treatment arms were included in meta-analy ..read more
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Cerebral Folate Transport Deficiency in 2 Cases with Intractable Myoclonic Epilepsy
Journal of Epilepsy Research
by
2w ago
Cerebral folate transport deficiency due to folate receptor 1 gene (FOLR1) gene mutation results from impaired folate transport across the blood: choroidplexus: cerebrospinal fluid (CSF) barrier. This leads to low CSF 5-methyltetrahydrofolate, the active folate metabolite. We are reporting two children with this treatable cerebral folate transport deficiency. Eight years and 9-month-old female presented with delayed milestones followed by regression, seizures, and intention tremors. On examination child had microcephaly, generalized hypotonia, hyperreflexia, unsteady gait, and incoordination ..read more
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Developing of Biotin-Thiamine Responsive Basal Ganglia Disease after Accidental Ingestion of ...
Journal of Epilepsy Research
by
7M ago
Biotin-thiamine-responsive basal ganglia disease (BTBGD) is a rare, inherited neurometabolic disorder caused by mutations in the SLC19A3 gene and characterized by recurrent sub-acute episodes of encephalopathy that are often triggered by infections. Patients with BTBGD have classical neuroimaging findings and a dramatic response to high doses of thiamine. Herein, we report a 2 and a half-year-old Saudi girl presented with an acute onset of ataxia, slurred speech, and dysphagia, which was preceded by a history of accidental ingestion of around 20 mL of ethyl alcohol that is used in formulating ..read more
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