This German study looked at effectiveness, safety and impact of Tremfya (guselkumab) on sexuality and perceived stigmatization in patients with psoriasis. Quote: Background: G-EPOSS is a prospective, non-interventional, German multicentre study of patients with moderate-to-severe plaque psoriasis receiving guselkumab, a therapeutic monoclonal antibody targeting interleukin-23, in a real-world setting. Objectives: The objective of the study was to evaluate the effectiveness and safety of guselkumab, including its impact on skin, health-related quality of life (HRQoL), sexuality, and perceived ..read more

This study was passed to me by afternoonfix Scientists from The Australian National University (ANU) have discovered a gene mutation is responsible for causing psoriasis. Quote: According to ANU researcher Dr Chelisa Cardinez, if two copies of this mutated gene (known as IKBKB) are present, patients with psoriasis may go on to develop psoriatic arthritis, leaving them with joint pain, stiffness and swelling. Thanks to the world-first discovery from ANU, scientists now know what causes the progression from a skin-only disease to a skin and joint disease. It’s hoped the findings will lead to ..read more

Hi there, I've been using Enstilar foam with good results for a while now, but ever since I started using it, I developed a red rash around my nose and chin. At first I though it was down to a milk allergy I have, but I stopped using Enstilar for 3 days and the rash went away. I then started using it again and the rash came back. From looking online, it seems that it's allergic contact dermatitis, caused by Butylated Hydroxytoluene. Does anyone else have any experience with this? And does anyone know if there's a particular antihistamine that could combat this? I tried using a hydrocortisone ..read more

Well, after a seemingly endless wait I'm finally on Imraldi. I've had three injections in the last two weeks and can already see an improvement in some patches on my arms and side, though my legs have yet to take notice. My derm has yet to sort my blood tests out but hopefully they'll be fine. I'll try and keep you updated with progress and fingers crossed for good results ..read more

This French population based real world cohort study looked at pustular psoriasis (GPP) Quote: Background: GPP is a rare, chronic, neutrophilic skin disease, with limited real-world data characterizing patients with flares and the impact of flares on disease progression and morbidity. Objective: Describe the clinical characteristics of patients with GPP, comorbidities, disease epidemiology and frequency and severity of flares, and compare patients with GPP with a matched severe psoriasis population. Methods: In this population-based real-world cohort study an algorithm was developed to iden ..read more

This study looked at  generalized pustular psoriasis (GPP) in Central and Eastern Europe. Quote: Background: Generalized pustular psoriasis (GPP) is a rare, inflammatory skin disease characterized by widespread eruption of sterile pustules with or without systemic symptoms. Objectives: This study aimed to describe the demographics of patients with GPP in Central and Eastern Europe (CEE), present the clinical characteristics of individual GPP flares and explore the current treatment landscape. Methods: Patient demographics were collected at the times of last observation and previous tre ..read more

These results follow on from this thread Piclidenoson submits registration plans for psoriasis Quote: Objective: A3 adenosine receptor (A3AR) is overexpressed in the skin and peripheral blood mononuclear cells of psoriasis patients. We investigated the efficacy/safety of piclidenoson (CF101), an orally bioavailable A3AR agonist that inhibits IL-17 and IL-23 production in keratinocytes, in moderate-to-severe plaque psoriasis. Methods: The randomized, placebo- and active-controlled, double-blind phase 3 COMFORT-1 trial randomized patients (3:3:3:2) to piclidenoson 2 mg BID, piclidenoson 3 mg B ..read more

I will link my first thread here (or ask Fred to) once it's determined how he wants to handle it.  However, I wanted a bit more uncluttered thread that deals with my experience of actually using Skyrizi. Today I received my Skyrizi: It was nicely packaged and as you can see the card has the white dot meaning that the temperature wasn't compromised (it would be red otherwise) Two pens, Week 0 and week 4 (the next one will be week 16, I'll call for a refill at about 4 weeks before it's due) Not much paperwork, one page describing how the temperature card works which a simple sentenc ..read more

I have psoriasis under 2 finger nails. Luckily for me 1 has cleared up (mostly) but my thumb nail is tough as old boots and I keep it short so I don’t catch it. I now have psoriasis under one toe nail. It’s lifting off and I’m unsure whether to cut it right down as far as possible as it sometimes catches on my sock. It’s only lifting on the left side but it’s nearly down to the bottom and I’m concerned it’ll get ripped off and that’ll hurt! Can anyone advise please ..read more

I started seeing a new dermatologist. As we were going over medical history stuff, I mentioned that I had been diagnosed with NAFLD (nonalcoholic fatty liver disease) and she replied that was common for people with psoriasis. Which surprised me a bit as I hadn't heard that before, nor had it been mentioned to me so I did a little looking up on the internet to see what I could find. I found the following information which seemed to explain it best: Although many people think of psoriasis primarily as a skin disease, it is a systemic condition that affects other organs as well. People with psor ..read more